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Rnf111 Gene Detail
Summary
  • Symbol
    Rnf111
  • Name
    ring finger protein 111
  • Synonyms
    Arkadia
  • Feature Type
    protein coding gene
  • IDs
    MGI:1934919
    NCBI Gene: 93836
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:70332706-70411007 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 39.53 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1377 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1934919
 protein coding gene Chr9:70332706-70411122 (-)
129S1/SvImJ ENSMUSG00200042712
 protein coding gene Chr9:67432595-67511725 (-)
A/J ENSMUSG00195025770
 protein coding gene Chr9:67210416-67289356 (-)
AKR/J ENSMUSG00220037912
 protein coding gene Chr9:67344524-67423138 (-)
BALB/cJ ENSMUSG00180016213
 protein coding gene Chr9:67324762-67403708 (-)
C3H/HeJ ENSMUSG00175010939
 protein coding gene Chr9:67338138-67417078 (-)
C57BL/6NJ ENSMUSG00215030801
 protein coding gene Chr9:67276146-67354985 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032403
 protein coding gene Chr9:67604854-67674439 (-)
CAST/EiJ ENSTCUG00005026904
 protein coding gene Chr9:67153161-67231855 (-)
CBA/J ENSMUSG00210013895
 protein coding gene Chr9:67418850-67497782 (-)
DBA/2J ENSMUSG00185033195
 protein coding gene Chr9:67442573-67521509 (-)
FVB/NJ ENSMUSG00205016535
 protein coding gene Chr9:67716838-67795765 (-)
JF1/MsJ ENSUMUG00000010101
 protein coding gene Chr9:67477718-67556679 (-)
LP/J ENSMUSG00230024687
 protein coding gene Chr9:67627725-67706858 (-)
NOD/ShiLtJ ENSMUSG00190020519
 protein coding gene Chr9:67541665-67620580 (-)
NZO/HlLtJ ENSMUSG00225046002
 protein coding gene Chr9:67748141-67827005 (-)
PWK/PhJ ENSLUMG00010026361
 protein coding gene Chr9:67415736-67494299 (-)
SPRET/EiJ ENSMSPG00010018926
 protein coding gene Chr9:68507063-68576899 (-)
WSB/EiJ ENSIUOG00005023530
 protein coding gene Chr9:66906025-66984896 (-)



Homology
more
  • Human Ortholog
    RNF111, ring finger protein 111
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RNF111, ring finger protein 111
  • Synonyms
    ARK, hRNF111
  • Links
    NCBI Gene ID: 54778
    UniProt: Q6ZNA4

  • Chr Location
    15q22.1-q22.2; chr15:58865175-59097419 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Rnf111 mouse models

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 3 alleles in 3 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele fail to develop anterior structures and midline with failure to develop anterior endoderm, node and mesendoderm.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    668
  • Tissues
    61
  • cDNA Data
    17
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032217 Ensembl Gene Model | MGI Sequence Detail 78302 C57BL/6J ±  kb
    transcript ENSMUST00000034739 Ensembl | MGI Sequence Detail 4880 Not Applicable  
    polypeptide ENSMUSP00000034739 Ensembl | MGI Sequence Detail 989 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 18
      Primer pair 2
      Antibodies 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 7
      Diseases 1
      Gene Ontology 15
      Phenotypes 16
    • Earliest
      J:10931 Hara Y, et al., Structure of mouse vasopressin and oxytocin genes. Brain Res Mol Brain Res. 1990 Oct;8(4):319-24
    • Latest
      J:361059 Song C, et al., Deleterious variants in RNF111 impair female fertility and induce premature ovarian insufficiency in humans and mice. Sci China Life Sci. 2024 Jul;67(7):1325-1337
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory