Eif5a2 MGI Mouse Gene Detail - MGI:1933735 - eukaryotic translation initiation factor 5A2

Symbol

Eif5a2
Name

eukaryotic translation initiation factor 5A2

Feature Type

protein coding gene
IDs

MGI:1933735
NCBI Gene: 208691
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr3:28835426-28852995 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 12.25 cM
Mapping Data

3 experiments

SNPs within 2kb

600 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1933735	protein coding gene	Chr3:28835425-28852995 (+)
129S1/SvImJ	ENSMUSG00200024297	protein coding gene	Chr3:25555544-25573114 (+)
A/J	ENSMUSG00195020908	protein coding gene	Chr3:25667796-25685627 (+)
AKR/J	ENSMUSG00220007940	protein coding gene	Chr3:25684500-25702324 (+)
BALB/cJ	ENSMUSG00180032435	protein coding gene	Chr3:25682637-25700207 (+)
C3H/HeJ	ENSMUSG00175026068	protein coding gene	Chr3:25658694-25676529 (+)
C57BL/6NJ	ENSMUSG00215013476	protein coding gene	Chr3:25932290-25949860 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024896	protein coding gene	Chr3:23919836-23937366 (+)
CAST/EiJ	ENSTCUG00005024406	protein coding gene	Chr3:25523779-25541617 (+)
CBA/J	ENSMUSG00210035967	protein coding gene	Chr3:25644523-25662357 (+)
DBA/2J	ENSMUSG00185009242	protein coding gene	Chr3:25905323-25923146 (+)
FVB/NJ	ENSMUSG00205007219	protein coding gene	Chr3:25227566-25245173 (+)
JF1/MsJ	ENSUMUG00000002505	protein coding gene	Chr3:25386694-25404467 (+)
LP/J	ENSMUSG00230001544	protein coding gene	Chr3:27784988-27802558 (+)
NOD/ShiLtJ	ENSMUSG00190034344	protein coding gene	Chr3:25955079-25972685 (+)
NZO/HlLtJ	ENSMUSG00225006702	protein coding gene	Chr3:30419543-30437113 (+)
PWK/PhJ	ENSLUMG00010034156	protein coding gene	Chr3:25371225-25388996 (+)
SPRET/EiJ	ENSMSPG00010022610	protein coding gene	Chr3:25774704-25788988 (+)
WSB/EiJ	ENSIUOG00005033208	protein coding gene	Chr3:25932415-25950245 (+)

Human Ortholog

EIF5A2, eukaryotic translation initiation factor 5A2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

EIF5A2, eukaryotic translation initiation factor 5A2
Synonyms

EIF-5A2, eIF5AII
Links

HGNC:3301

NCBI Gene ID: 56648

UniProt: Q9GZV4
Chr Location

3q26.2; chr3:170888418-170908644 (-) GRCh38

MGI Vertebrate Homology

Eif5a2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: EIF5A2
Protein SuperFamily

eIF5A
Gene Tree

Eif5a2

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References

1 with disease annotations

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
7 phenotype references

All Mutations and Alleles

12
Endonuclease-mediated

7
Radiation induced

1
Targeted

4
Genomic Mutations

1 involving Eif5a2
Find Mice (IMSR)

11 strains or lines available

Mice homozygous for a knockout allele exhibit no abnormal phenotype.

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All GO Annotations

12
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

28

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase eif5a2

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All Sequences

42
RefSeq

2
UniProt

1
CCDS

CCDS17277.1

Ensembl

ENSMUSG00000050192 (Evidence)
NCBI Gene

208691

			Length	Strain/Species	Flank
genomic	208691	NCBI Gene Model \| MGI Sequence Detail	17570	C57BL/6J	± kb
transcript	NM_177586	RefSeq \| MGI Sequence Detail	5026	C57BL/6
polypeptide	Q8BGY2	UniProt \| EBI \| MGI Sequence Detail	153	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000007004 eukaryotic translation initiation factor 5A-2

(term hierarchy)
InterPro Domains

IPR014722 Large ribosomal subunit protein uL2, domain 2

IPR012340 Nucleic acid-binding, OB-fold

IPR001884 Translation elongation factor IF5A-like

IPR020189 Translation initiation factor 5A, C-terminal

IPR019769 Translation initiation factor 5A, hypusine site

IPR048670 Translation initiation factor 5A-like, N-terminal

IPR008991 Translation protein SH3-like domain superfamily

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All nucleic 28

cDNA 28

Microarray probesets 5

Summaries

All 34

Diseases 1

Gene Ontology 4

Phenotypes 7
Earliest

J:66988 Jenkins ZA, et al., Human eif5a2 on chromosome 3q25-q27 is a phylogenetically conserved vertebrate variant of eukaryotic translation initiation factor 5a with tissue-specific expression. Genomics. 2001 Jan 1;71(1):101-9
Latest

J:360415 Connors CT, et al., A Translational Regulatory Mechanism Mediated by Hypusinated Eukaryotic Initiation Factor 5A Facilitates beta-Cell Identity and Function. Diabetes. 2024 Mar 1;73(3):461-473

TSS for Eif5a2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr28659	Chr3:28835454-28835493 (+)	48 bp
Tssr28660	Chr3:28835494-28835523 (+)	83 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24