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Tmprss5 Gene Detail
Summary
  • Symbol
    Tmprss5
  • Name
    transmembrane protease, serine 5 (spinesin)
  • Synonyms
    spinesin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933407
    NCBI Gene: 80893
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:49013994-49028891 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 26.59 cM, cytoband B
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    441 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1933407
 protein coding gene Chr9:48992560-49028891 (+)
129S1/SvImJ ENSMUSG00200018044
 protein coding gene Chr9:46158982-46195317 (+)
A/J ENSMUSG00195023326
 protein coding gene Chr9:45840323-45876636 (+)
AKR/J ENSMUSG00220030336
 protein coding gene Chr9:45931549-45967888 (+)
BALB/cJ ENSMUSG00180027933
 protein coding gene Chr9:45951685-45987998 (+)
C3H/HeJ ENSMUSG00175012630
 protein coding gene Chr9:45963856-46000175 (+)
C57BL/6NJ ENSMUSG00215030560
 protein coding gene Chr9:45915987-45952316 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032175
 protein coding gene Chr9:45975494-45991015 (+)
CAST/EiJ ENSTCUG00005014203
 protein coding gene Chr9:45890708-45928186 (+)
CBA/J ENSMUSG00210016527
 protein coding gene Chr9:46040455-46076770 (+)
DBA/2J ENSMUSG00185008999
 protein coding gene Chr9:46078118-46114429 (+)
FVB/NJ ENSMUSG00205038627
 protein coding gene Chr9:46313769-46350933 (+)
JF1/MsJ ENSUMUG00000028351
 protein coding gene Chr9:46137814-46174413 (+)
LP/J ENSMUSG00230036915
 protein coding gene Chr9:46375568-46411899 (+)
NOD/ShiLtJ ENSMUSG00190017622
 protein coding gene Chr9:46164876-46201230 (+)
NZO/HlLtJ ENSMUSG00225043884
 protein coding gene Chr9:46337070-46373399 (+)
PWK/PhJ ENSLUMG00010020373
 protein coding gene Chr9:46101540-46137865 (+)
SPRET/EiJ ENSMSPG00010010836
 protein coding gene Chr9:46895559-46910768 (+)
WSB/EiJ ENSIUOG00005017512
 protein coding gene Chr9:45570032-45606386 (+)



Homology
more
  • Human Ortholog
    TMPRSS5, transmembrane serine protease 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMPRSS5, transmembrane serine protease 5
  • Synonyms
    SPINESIN
  • Links
    NCBI Gene ID: 80975
    UniProt: Q9H3S3

  • Chr Location
    11q23.2; chr11:113687543-113706382 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    621
  • Tissues
    15
  • cDNA Data
    6
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 80893 NCBI Gene Model | MGI Sequence Detail 14898 C57BL/6J ±  kb
transcript NM_030709 RefSeq | MGI Sequence Detail 2092 C57BL/6  
polypeptide Q9ER04 UniProt | EBI | MGI Sequence Detail 455 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 6
    cDNA 6

    Microarray probesets 2
References
more
  • Summaries
    All 30
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 6
  • Earliest
    J:93168 Watanabe Y, et al., Molecular cloning and tissue-specific expression analysis of mouse spinesin, a type II transmembrane serine protease 5. Biochem Biophys Res Commun. 2004 Nov 5;324(1):333-40
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory