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Gtf2a2 Gene Detail
Summary
  • Symbol
    Gtf2a2
  • Name
    general transcription factor II A, 2
  • Synonyms
    12kDa, Tfiia2, TfIIg
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933289
    NCBI Gene: 235459
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:69919832-69930148 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 9, 39.18 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    9 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1933289
protein coding gene Chr9:69919830-69930148 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034995
protein coding gene Chr9:70045143-70055460 (+)
A/J MGP_AJ_G0034976
protein coding gene Chr9:67631303-67641628 (+)
AKR/J MGP_AKRJ_G0034905
protein coding gene Chr9:69235842-69246134 (+)
BALB/cJ MGP_BALBcJ_G0034968
protein coding gene Chr9:67353453-67363781 (+)
C3H/HeJ MGP_C3HHeJ_G0034677
protein coding gene Chr9:69738498-69748834 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035487
protein coding gene Chr9:71919839-71930188 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032398
protein coding gene Chr9:67185372-67196913 (+)
CAST/EiJ MGP_CASTEiJ_G0033999
protein coding gene Chr9:70008416-70019721 (+)
CBA/J MGP_CBAJ_G0034650
protein coding gene Chr9:74428535-74438866 (+)
DBA/2J MGP_DBA2J_G0034809
protein coding gene Chr9:67376216-67386537 (+)
FVB/NJ MGP_FVBNJ_G0034751
protein coding gene Chr9:66693304-66703645 (+)
LP/J MGP_LPJ_G0034890
protein coding gene Chr9:70293863-70305238 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034792
protein coding gene Chr9:75517018-75527333 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035509
protein coding gene Chr9:69374149-69384465 (+)
PWK/PhJ MGP_PWKPhJ_G0033703
protein coding gene Chr9:67606971-67617652 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033536
protein coding gene Chr9:69681643-69691931 (+)
WSB/EiJ MGP_WSBEiJ_G0034111
protein coding gene Chr9:69264431-69274800 (+)



Homology
more
  • Human Ortholog
    GTF2A2, general transcription factor IIA subunit 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GTF2A2, general transcription factor IIA subunit 2
  • Synonyms
    HsT18745, T18745, TF2A2, TFIIA, TFIIA-12, TFIIA-gamma, TFIIAS
  • Links
    NCBI Gene ID: 2958
    neXtProt AC: NX_P52657
    UniProt: P52657

  • Chr Location
    15q22.2; chr15:59638062-59657541 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
  • All Mutations and Alleles
    42
  • Chemically induced (other)
    1
  • Gene trapped
    40
  • Targeted
    1
  • Genomic Mutations
    1 involving Gtf2a2
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000033543 Ensembl Gene Model | MGI Sequence Detail 10317 C57BL/6J ±  kb
transcript ENSMUST00000118198 Ensembl | MGI Sequence Detail 893 Not Applicable  
polypeptide ENSMUSP00000113501 Ensembl | MGI Sequence Detail 109 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    9 Sequences
  • Protein Ontology
    PR:000008312 transcription initiation factor IIA subunit 2
  • InterPro Domains
    IPR009083 Transcription factor IIA, alpha-helical domain
    IPR009088 Transcription factor IIA, beta-barrel
    IPR003194 Transcription initiation factor IIA, gamma subunit
    IPR015871 Transcription initiation factor IIA, gamma subunit, C-terminal
    IPR015872 Transcription initiation factor IIA, gamma subunit, N-terminal
Molecular
Reagents
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  • All nucleic 84
    cDNA 83
    Primer pair 1

    Microarray probesets 1
References
more
  • Summaries
    All 35
    Developmental Gene Expression 3
    Gene Ontology 7
    Phenotypes 8
  • Earliest
    J:320280 Roeder RG, The role of general initiation factors in transcription by RNA polymerase II. Trends Biochem Sci. 1996 Sep;21(9):327-35
  • Latest
    J:281311 Nakano Y, et al., Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST. Cell Rep. 2019 Apr 16;27(3):860-871.e8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
05/14/2024
MGI 6.23
The Jackson Laboratory