Tex14 MGI Mouse Gene Detail - MGI:1933227 - testis expressed gene 14 intercellular bridge forming factor

Symbol

Tex14
Name

testis expressed gene 14 intercellular bridge forming factor

Feature Type

protein coding gene
IDs

MGI:1933227
NCBI Gene: 83560
Alliance

genome feature page
Transcription Start Sites

5 TSS

Sequence Map

Chr11:87295891-87446649 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 52.09 cM
Mapping Data

3 experiments

SNPs within 2kb

515 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1933227	protein coding gene	Chr11:87295839-87446649 (+)
129S1/SvImJ	ENSMUSG00200018811	protein coding gene	Chr11:84447860-84576100 (+)
A/J	ENSMUSG00195008124	protein coding gene	Chr11:84302692-84430950 (+)
AKR/J	ENSMUSG00220010716	protein coding gene	Chr11:84502255-84630491 (+)
BALB/cJ	ENSMUSG00180010769	protein coding gene	Chr11:84509643-84637687 (+)
C3H/HeJ	ENSMUSG00175030500	protein coding gene	Chr11:84449302-84577541 (+)
C57BL/6NJ	ENSMUSG00215020334	protein coding gene	Chr11:84094013-84222261 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016929	protein coding gene	Chr11:82609403-82768922 (+)
CAST/EiJ	ENSTCUG00005016608	protein coding gene	Chr11:84004549-84132473 (+)
CBA/J	ENSMUSG00210033202	protein coding gene	Chr11:84266850-84395100 (+)
DBA/2J	ENSMUSG00185018776	protein coding gene	Chr11:84583564-84711800 (+)
FVB/NJ	ENSMUSG00205012267	protein coding gene	Chr11:84462624-84590684 (+)
JF1/MsJ	ENSUMUG00000014666	protein coding gene	Chr11:84907710-85036328 (+)
LP/J	ENSMUSG00230024669	protein coding gene	Chr11:85616829-85745066 (+)
NOD/ShiLtJ	ENSMUSG00190018182	protein coding gene	Chr11:84609457-84737506 (+)
NZO/HlLtJ	ENSMUSG00225038481	protein coding gene	Chr11:87732868-87860972 (+)
PWK/PhJ	ENSLUMG00010030822	protein coding gene	Chr11:84434879-84595213 (+)
SPRET/EiJ	no annotation
WSB/EiJ	ENSIUOG00005007516	protein coding gene	Chr11:84421716-84549599 (+)

Human Ortholog

TEX14, testis expressed 14, intercellular bridge forming factor

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TEX14, testis expressed 14, intercellular bridge forming factor
Synonyms

CT113, SgK307, SPGF23
Links

HGNC:11737

NCBI Gene ID: 56155

UniProt: Q8IWB6
Chr Location

17q22; chr17:58556678-58692055 (-) GRCh38

MGI Vertebrate Homology

Tex14 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TEX14
Gene Tree

Tex14

Diseases

1 with human TEX14 associations

				Human Disease	Mouse Models
				spermatogenic failure 23 IDs spermatogenic failure 23 DOID:0070181 OMIM:617707

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

8 phenotypes from 1 allele in 2 genetic backgrounds
3 images
30 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

100
Chemically induced (ENU)

1
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

88
Targeted

6
Genomic Mutations

2 involving Tex14
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

158 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Males homozygous for a targeted allele are infertile due to spermatogenic failure.

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All GO Annotations

32
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

610
Tissues

6
cDNA Data

13
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tex14

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All Sequences

63
RefSeq

19
UniProt

4
CCDS

CCDS48877.1

Ensembl

ENSMUSG00000010342 (Evidence)
NCBI Gene

83560

			Length	Strain/Species	Flank
genomic	ENSMUSG00000010342	Ensembl Gene Model \| MGI Sequence Detail	150759	C57BL/6J	± kb
transcript	ENSMUST00000060835	Ensembl \| MGI Sequence Detail	4763	Not Applicable
polypeptide	ENSMUSP00000054444	Ensembl \| MGI Sequence Detail	1450	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000016253 testis-expressed protein 14

(term hierarchy)
InterPro Domains

IPR002110 Ankyrin repeat

IPR036770 Ankyrin repeat-containing domain superfamily

IPR039339 Inactive serine/threonine-protein kinase TEX14

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain

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All nucleic 15

Genomic 1

cDNA 13

Primer pair 1

Antibodies 4

Microarray probesets 2

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MGI:2144681

Summaries

All 71

Developmental Gene Expression 9

Gene Ontology 11

Phenotypes 30
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:383474 Pathak M, et al., Mouse germline cysts contain a fusome-like structure that mediates oocyte development. Elife. 2026 Mar 11;14

TSS for Tex14:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr103922	Chr11:87295862-87295871 (+)	-24 bp
Tssr103923	Chr11:87295875-87295939 (+)	16 bp
Tssr103924	Chr11:87324044-87324086 (+)	28,174 bp
Tssr103926	Chr11:87362418-87362429 (+)	66,533 bp
Tssr103927	Chr11:87362492-87362500 (+)	66,605 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24