Tdrd1 MGI Mouse Gene Detail - MGI:1933218 - tudor domain containing 1

Symbol

Tdrd1
Name

tudor domain containing 1
Synonyms

MTR-1

Feature Type

protein coding gene
IDs

MGI:1933218
NCBI Gene: 83561
Alliance

genome feature page
Transcription Start Sites

4 TSS

Sequence Map

Chr19:56814641-56858444 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 52.00 cM
Mapping Data

1 experiment

SNPs within 2kb

1374 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1933218	protein coding gene	Chr19:56814603-56858444 (+)
129S1/SvImJ	ENSMUSG00200014161	protein coding gene	Chr19:53521243-53566929 (+)
A/J	ENSMUSG00195002337	protein coding gene	Chr19:53692482-53738105 (+)
AKR/J	ENSMUSG00220017233	protein coding gene	Chr19:53443892-53489566 (+)
BALB/cJ	ENSMUSG00180017619	protein coding gene	Chr19:53931570-53977188 (+)
C3H/HeJ	ENSMUSG00175021913	protein coding gene	Chr19:53467364-53512975 (+)
C57BL/6NJ	ENSMUSG00215018524	protein coding gene	Chr19:53551563-53597252 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023095	protein coding gene	Chr19:53296587-53343928 (+)
CAST/EiJ	ENSTCUG00005015225	protein coding gene	Chr19:53102031-53145982 (+)
CBA/J	ENSMUSG00210020245	protein coding gene	Chr19:53546692-53592308 (+)
DBA/2J	ENSMUSG00185027967	protein coding gene	Chr19:54045532-54091148 (+)
FVB/NJ	ENSMUSG00205003383	protein coding gene	Chr19:52952354-52998047 (+)
JF1/MsJ	ENSUMUG00000028885	protein coding gene	Chr19:54230381-54275986 (+)
LP/J	ENSMUSG00230024499	protein coding gene	Chr19:54802715-54848392 (+)
NOD/ShiLtJ	ENSMUSG00190011351	protein coding gene	Chr19:53419735-53465406 (+)
NZO/HlLtJ	ENSMUSG00225024900	protein coding gene	Chr19:58408408-58454088 (+)
PWK/PhJ	ENSLUMG00010018503	protein coding gene	Chr19:53295135-53340545 (+)
SPRET/EiJ	ENSMSPG00010002866	protein coding gene	Chr19:53150564-53190165 (+)
WSB/EiJ	ENSIUOG00005022709	protein coding gene	Chr19:52904219-52949834 (+)

Human Ortholog

TDRD1, tudor domain containing 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TDRD1, tudor domain containing 1
Synonyms

CT41.1
Links

HGNC:11712

NCBI Gene ID: 56165

UniProt: Q9BXT4
Chr Location

10q25.3; chr10:114174874-114232666 (+) GRCh38

MGI Vertebrate Homology

Tdrd1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TDRD1
Gene Tree

Tdrd1

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Phenotype Summary

10 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

5
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

51 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Male homozygous mice are sterile, displaying postnatal spermatogenic defects. Females are fertile.

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All GO Annotations

21
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

661
Tissues

28
cDNA Data

14
Literature Summary

26

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tdrd1

ZFIN tdrd1

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All Sequences

64
RefSeq

22
UniProt

1
CCDS

CCDS29922.1

Ensembl

ENSMUSG00000025081 (Evidence)
NCBI Gene

83561

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025081	Ensembl Gene Model \| MGI Sequence Detail	43804	C57BL/6J	± kb
transcript	ENSMUST00000111606	Ensembl \| MGI Sequence Detail	4914	Not Applicable
polypeptide	ENSMUSP00000107233	Ensembl \| MGI Sequence Detail	1172	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000016216 tudor domain-containing protein 1

(term hierarchy)
PDB

4B9W, 4B9X
InterPro Domains

IPR035437 SNase-like, OB-fold superfamily

IPR002999 Tudor domain

IPR050621 Tudor domain-containing

IPR047376 Tudor domain-containing protein 1, first Tudor domain

IPR047377 Tudor domain-containing protein 1, second Tudor domain

IPR047378 Tudor domain-containing protein 1, third Tudor domain

IPR002893 Zinc finger, MYND-type
GlyGen

Q99MV1 1 site

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All nucleic 18

cDNA 14

Primer pair 4

Antibodies 4

Microarray probesets 2

Summaries

All 61

Developmental Gene Expression 26

Gene Ontology 13

Phenotypes 12
Earliest

J:68614 Wang PJ, et al., An abundance of X-linked genes expressed in spermatogonia. Nat Genet. 2001 Apr;27(4):422-6
Latest

J:359747 Gao J, et al., TDRD1 phase separation drives intermitochondrial cement assembly to promote piRNA biogenesis and fertility. Dev Cell. 2024 Jul 16;

TSS for Tdrd1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr157216	Chr19:56814634-56814680 (+)	16 bp
Tssr157217	Chr19:56814700-56814720 (+)	69 bp
Tssr157218	Chr19:56814936-56814945 (+)	300 bp
Tssr157219	Chr19:56840376-56840386 (+)	25,740 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24