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Gsdmc Gene Detail
Summary
  • Symbol
    Gsdmc
  • Name
    gasdermin C
  • Synonyms
    Gsdmc1, Mlze
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933176
    NCBI Gene: 83492
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:63647820-63680588 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 27.79 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    102 from dbSNP Build 142
  • Strain Annotations
    15
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1933176
 protein coding gene Chr15:63647817-63680608 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021891
 protein coding gene Chr15:63208113-63238779 (-)
A/J MGP_AJ_G0021850
 protein coding gene Chr15:60735525-60767479 (-)
AKR/J MGP_AKRJ_G0021832
 protein coding gene Chr15:62431110-62468649 (-)
BALB/cJ MGP_BALBcJ_G0021857
 protein coding gene Chr15:60913487-61121434 (-)
C3H/HeJ MGP_C3HHeJ_G0021631
 protein coding gene Chr15:62559486-62610542 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022296
 protein coding gene Chr15:65603061-65656018 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019835
 protein coding gene Chr15:57735486-57747422 (-)
CAST/EiJ MGP_CASTEiJ_G0021151
 protein coding gene Chr15:63241464-63249134 (-)
CBA/J MGP_CBAJ_G0021600
 protein coding gene Chr15:67806309-67861024 (-)
DBA/2J MGP_DBA2J_G0021724
 protein coding gene Chr15:60577282-60607682 (-)
FVB/NJ MGP_FVBNJ_G0021703
 protein coding gene Chr15:59630253-59670388 (-)
LP/J MGP_LPJ_G0021795
 protein coding gene Chr15:63088163-63108715 (-)
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ MGP_PWKPhJ_G0020894
 protein coding gene Chr15:60677968-60688364 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020732
 protein coding gene Chr15:62823365-62832069 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    GSDMC, gasdermin C
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GSDMC, gasdermin C
  • Synonyms
    MLZE
  • Links
    NCBI Gene ID: 56169
    neXtProt AC: NX_Q9BYG8
    UniProt: Q9BYG8

  • Chr Location
    8q24.21; chr8:129705435-129786624 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    834
  • Tissues
    113
  • cDNA Data
    5
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 83492 NCBI Gene Model | MGI Sequence Detail 32769 C57BL/6J ±  kb
    transcript NM_031378 RefSeq | MGI Sequence Detail 2382 C57BL/6  
    polypeptide Q99NB5 UniProt | EBI | MGI Sequence Detail 468 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 6
      cDNA 6

      Microarray probesets 3
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 5
      Phenotypes 32
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:333467 Du J, et al., N(6)-adenomethylation of GsdmC is essential for Lgr5(+) stem cell survival to maintain normal colonic epithelial morphogenesis. Dev Cell. 2022 Aug 22;57(16):1976-1994.e8
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory