Bri3 MGI Mouse Gene Detail - MGI:1933174

Symbol

Bri3
Name

brain protein I3
Synonyms

I3 protein

Feature Type

protein coding gene
IDs

MGI:1933174
NCBI Gene: 55950
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr5:144181247-144383567 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 83.19 cM, cytoband G2
Mapping Data

1 experiment

SNPs within 2kb

12255 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1933174	protein coding gene	Chr5:144181247-144383567 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030348	protein coding gene	Chr5:149575775-149798910 (+)
A/J	MGP_AJ_G0030317	protein coding gene	Chr5:143155757-143363802 (+)
AKR/J	MGP_AKRJ_G0030249	protein coding gene	Chr5:147626884-147838499 (+)
BALB/cJ	MGP_BALBcJ_G0030334	protein coding gene	Chr5:144433605-144634308 (+)
C3H/HeJ	MGP_C3HHeJ_G0030045	protein coding gene	Chr5:148468840-148680036 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030779	protein coding gene	Chr5:155047480-155275105 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027998	protein coding gene	Chr5:136940104-137147594 (+)
CAST/EiJ	MGP_CASTEiJ_G0029450	protein coding gene	Chr5:147986150-148218079 (+)
CBA/J	MGP_CBAJ_G0030015	protein coding gene	Chr5:161416103-161652688 (+)
DBA/2J	MGP_DBA2J_G0030165	protein coding gene	Chr5:142903236-143110250 (+)
FVB/NJ	MGP_FVBNJ_G0030120	protein coding gene	Chr5:142136852-142335717 (+)
LP/J	MGP_LPJ_G0030251	protein coding gene	Chr5:150192434-150399519 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030151	protein coding gene	Chr5:163779714-164022214 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030819	protein coding gene	Chr5:147513218-147738883 (+)
PWK/PhJ	MGP_PWKPhJ_G0029165	protein coding gene	Chr5:142018335-142232108 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029001	protein coding gene	Chr5:145249931-145464641 (+)
WSB/EiJ	MGP_WSBEiJ_G0029523	protein coding gene	Chr5:148308410-148532929 (+)

Human Ortholog

BRI3, brain protein I3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

BRI3, brain protein I3
Synonyms

I3
Links

HGNC:1109

NCBI Gene ID: 25798

neXtProt AC: NX_O95415

UniProt: O95415
Chr Location

7q21.3; chr7:98252379-98323430 (+) GRCh38

MGI Vertebrate Homology

Bri3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: BRI3
Gene Tree

Bri3

less

Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Endonuclease-mediated

3
Gene trapped

10
Targeted

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

11 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

less

All GO Annotations

7
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

707
Tissues

1
cDNA Data

48
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase bri3

less

All Sequences

46
RefSeq

8
UniProt

4
CCDS

CCDS19848.1, CCDS51694.1

Ensembl

ENSMUSG00000047843 (Evidence)
NCBI Gene

55950

			Length	Strain/Species	Flank
genomic	55950	NCBI Gene Model \| MGI Sequence Detail	202321	C57BL/6J	± kb
transcript	NR_190571	RefSeq \| MGI Sequence Detail	1073	C57BL/6
polypeptide	P28662	UniProt \| EBI \| MGI Sequence Detail	125	Not Applicable

less

UniProt

4 Sequences
Protein Ontology

PR:000004814 membrane protein BRI3

(term hierarchy)
InterPro Domains

IPR019317 Membrane protein BRI3

less

All nucleic 49

cDNA 48

Primer pair 1

Microarray probesets 3

Summaries

All 33

Developmental Gene Expression 2

Gene Ontology 4

Phenotypes 8
Earliest

J:15086 Kato K, A collection of cDNA clones with specific expression patterns in mouse brain. Eur J Neurosci. 1990;2(8):704-11
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Bri3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr49695	Chr5:144181228-144181237 (+)	-14 bp
Tssr49696	Chr5:144181242-144181267 (+)	8 bp
Tssr49697	Chr5:144192033-144192052 (+)	10,796 bp
Tssr49698	Chr5:144192054-144192094 (+)	10,827 bp
Tssr49699	Chr5:144192095-144192109 (+)	10,855 bp
Tssr49700	Chr5:144192590-144192612 (+)	11,354 bp
Tssr49701	Chr5:144192615-144192633 (+)	11,377 bp
Tssr49702	Chr5:144192634-144192652 (+)	11,396 bp
Tssr49703	Chr5:144192893-144192922 (+)	11,661 bp
Tssr49704	Chr5:144192923-144192944 (+)	11,687 bp
Tssr49705	Chr5:144192946-144192964 (+)	11,708 bp
Tssr1745	Chr5:144231920-144231927 (+)	50,677 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24