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Mettl27 Gene Detail
Summary
  • Symbol
    Mettl27
  • Name
    methyltransferase like 27
  • Synonyms
    MGC:8159, Wbscr27
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933146
    NCBI Gene: 79565
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:134961222-134971491 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 5, 74.89 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    52 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1933146
protein coding gene Chr5:134961158-134971491 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030166
protein coding gene Chr5:139401076-139411644 (+)
A/J MGP_AJ_G0030134
protein coding gene Chr5:133455070-133464908 (+)
AKR/J MGP_AKRJ_G0030067
protein coding gene Chr5:137796071-137805856 (+)
BALB/cJ MGP_BALBcJ_G0030144
protein coding gene Chr5:134810477-134820812 (+)
C3H/HeJ MGP_C3HHeJ_G0029860
protein coding gene Chr5:138352075-138363318 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030597
protein coding gene Chr5:144635539-144645766 (+)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0029269
protein coding gene Chr5:137777524-137787234 (+)
CBA/J MGP_CBAJ_G0029830
protein coding gene Chr5:150285534-150295916 (+)
DBA/2J MGP_DBA2J_G0029981
protein coding gene Chr5:133351550-133361554 (+)
FVB/NJ MGP_FVBNJ_G0029936
protein coding gene Chr5:132483725-132494001 (+)
LP/J MGP_LPJ_G0030069
protein coding gene Chr5:139860350-139871914 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029968
protein coding gene Chr5:153307713-153318100 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030637
protein coding gene Chr5:137529220-137540844 (+)
PWK/PhJ MGP_PWKPhJ_G0028984
protein coding gene Chr5:132395292-132405357 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028819
protein coding gene Chr5:135099977-135111000 (+)
WSB/EiJ MGP_WSBEiJ_G0029343
protein coding gene Chr5:138284966-138295746 (+)



Homology
more
  • Human Ortholog
    METTL27, methyltransferase like 27
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    METTL27, methyltransferase like 27
  • Synonyms
    WBSCR27
  • Links
    NCBI Gene ID: 155368
    neXtProt AC: NX_Q8N6F8
    UniProt: Q8N6F8

  • Chr Location
    7q11.23; chr7:73834590-73842516 (-)  GRCh38

Human Diseases
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  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotype references
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000040557 Ensembl Gene Model | MGI Sequence Detail 10270 C57BL/6J ±  kb
transcript ENSMUST00000047196 Ensembl | MGI Sequence Detail 2808 Not Applicable  
polypeptide ENSMUSP00000039080 Ensembl | MGI Sequence Detail 238 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    7 Sequences
  • PDB
  • InterPro Domains
    IPR041698 Methyltransferase domain 25
    IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
Molecular
Reagents
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  • All nucleic 7
    Genomic 1
    cDNA 6

    Microarray probesets 3
Other
Accession IDs
less
MGI:2141200
References
more
  • Summaries
    All 35
    Diseases 2
    Phenotypes 15
  • Earliest
    J:73830 DeSilva U, et al., Generation and comparative analysis of approximately 3.3 Mb of mouse genomic sequence orthologous to the region of human chromosome 7q11.23 implicated in Williams syndrome. Genome Res. 2002 Jan;12(1):3-15
  • Latest
    J:337436 Abdalla N, et al., Dysfunctional Mitochondria in the Cardiac Fibers of a Williams-Beuren Syndrome Mouse Model. Int J Mol Sci. 2023 Jun 13;24(12)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory