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Bcl9l Gene Detail
Summary
  • Symbol
    Bcl9l
  • Name
    B cell CLL/lymphoma 9-like
  • Synonyms
    DLNB11, MGC:7014
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933114
    NCBI Gene: 80288
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:44394122-44423193 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 24.84 cM, cytoband B
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    95 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1933114
 protein coding gene Chr9:44394122-44423203 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034712
 protein coding gene Chr9:42978695-43007598 (+)
A/J MGP_AJ_G0034693
 protein coding gene Chr9:41775288-41804148 (+)
AKR/J MGP_AKRJ_G0034620
 protein coding gene Chr9:42660795-42672047 (+)
BALB/cJ MGP_BALBcJ_G0034684
 protein coding gene Chr9:41537752-41550289 (+)
C3H/HeJ MGP_C3HHeJ_G0034395
 protein coding gene Chr9:43099432-43128078 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035205
 protein coding gene Chr9:44248644-44279419 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032120
 protein coding gene Chr9:41375682-41386888 (+)
CAST/EiJ MGP_CASTEiJ_G0033717
 protein coding gene Chr9:42942955-42973308 (+)
CBA/J MGP_CBAJ_G0034367
 protein coding gene Chr9:45867889-45898940 (+)
DBA/2J MGP_DBA2J_G0034526
 protein coding gene Chr9:41694152-41705466 (+)
FVB/NJ MGP_FVBNJ_G0034467
 protein coding gene Chr9:40937002-40964757 (+)
LP/J MGP_LPJ_G0034607
 protein coding gene Chr9:43279139-43305879 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034511
 protein coding gene Chr9:47697184-47726913 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035226
 protein coding gene Chr9:42544239-42575277 (+)
PWK/PhJ MGP_PWKPhJ_G0033423
 protein coding gene Chr9:41575678-41586949 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033257
 protein coding gene Chr9:42862688-42891776 (+)
WSB/EiJ MGP_WSBEiJ_G0033830
 protein coding gene Chr9:42580689-42610112 (+)



Homology
more
  • Human Ortholog
    BCL9L, BCL9 like
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BCL9L, BCL9 like
  • Synonyms
    B9L, BCL9-2, DLNB11
  • Links
    NCBI Gene ID: 283149
    neXtProt AC: NX_Q86UU0
    UniProt: Q86UU0

  • Chr Location
    11q23.3; chr11:118893875-118925926 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show lethality around E10.5-E11, embryonic growth arrest around E10, and complete block of branching morphogenesis and labyrinth layer formation in the placenta.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    949
  • Tissues
    34
  • cDNA Data
    51
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000063382 Ensembl Gene Model | MGI Sequence Detail 29072 C57BL/6J ±  kb
    transcript ENSMUST00000218183 Ensembl | MGI Sequence Detail 6771 Not Applicable  
    polypeptide ENSMUSP00000151837 Ensembl | MGI Sequence Detail 1494 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 53
      cDNA 51
      Primer pair 1
      Other 1

      Microarray probesets 6
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 6
      Gene Ontology 10
      Phenotypes 20
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:312447 Vafaizadeh V, et al., The interactions of Bcl9/Bcl9L with beta-catenin and Pygopus promote breast cancer growth, invasion, and metastasis. Oncogene. 2021 Oct;40(43):6195-6209
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory