Klb MGI Mouse Gene Detail - MGI:1932466

Symbol

Klb
Name

klotho beta
Synonyms

betaKlotho

Feature Type

protein coding gene
IDs

MGI:1932466
NCBI Gene: 83379
Alliance

genome feature page
Transcription Start Sites

3 TSS

Sequence Map

Chr5:65505657-65541350 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 33.64 cM
Mapping Data

1 experiment

SNPs within 2kb

1067 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1932466	protein coding gene	Chr5:65505657-65544300 (+)
129S1/SvImJ	ENSMUSG00200035159	protein coding gene	Chr5:61123060-61158756 (+)
A/J	ENSMUSG00195000239	protein coding gene	Chr5:60493367-60529071 (+)
AKR/J	ENSMUSG00220007043	protein coding gene	Chr5:60635080-60670734 (+)
BALB/cJ	ENSMUSG00180005861	protein coding gene	Chr5:60279199-60314902 (+)
C3H/HeJ	ENSMUSG00175025165	protein coding gene	Chr5:62313530-62349508 (+)
C57BL/6NJ	ENSMUSG00215005229	protein coding gene	Chr5:61051924-61087623 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027246	protein coding gene	Chr5:58640189-58677744 (+)
CAST/EiJ	ENSTCUG00005000234	protein coding gene	Chr5:60202297-60238169 (+)
CBA/J	ENSMUSG00210022978	protein coding gene	Chr5:61226493-61262460 (+)
DBA/2J	ENSMUSG00185005281	protein coding gene	Chr5:63084003-63119972 (+)
FVB/NJ	ENSMUSG00205010265	protein coding gene	Chr5:60035794-60071456 (+)
JF1/MsJ	ENSUMUG00000017793	protein coding gene	Chr5:67554837-67590806 (+)
LP/J	ENSMUSG00230006116	protein coding gene	Chr5:67735818-67771511 (+)
NOD/ShiLtJ	ENSMUSG00190000260	protein coding gene	Chr5:60218444-60254153 (+)
NZO/HlLtJ	ENSMUSG00225009917	protein coding gene	Chr5:72861885-72897566 (+)
PWK/PhJ	ENSLUMG00010004087	protein coding gene	Chr5:60162219-60198319 (+)
SPRET/EiJ	ENSMSPG00010033642	protein coding gene	Chr5:61983431-62016091 (+)
WSB/EiJ	ENSIUOG00005016457	protein coding gene	Chr5:63175108-63211155 (+)

Human Ortholog

KLB, klotho beta

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KLB, klotho beta
Synonyms

BKL
Links

HGNC:15527

NCBI Gene ID: 152831

UniProt: Q86Z14
Chr Location

4p14; chr4:39406930-39451533 (+) GRCh38

MGI Vertebrate Homology

Klb stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: KLB
Gene Tree

Klb

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Phenotype Summary

26 phenotypes from 5 alleles in 6 genetic backgrounds
25 phenotypes from multigenic genotypes
85 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

28
Chemically induced (other)

2
Endonuclease-mediated

11
Gene trapped

2
Radiation induced

1
Spontaneous

1
Targeted

10
Transgenic

1
Genomic Mutations

4 involving Klb
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

58 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygous null mice display increased bile acid synthesis and excretion, resistance to gallstone formation, and slightly decreased body weight. Mice homozygous for a knock-out allele or a conditional allele activated in adipose tissue exhibit resistanceto FGF21-induced metabolic disruptions.

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All GO Annotations

20
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

649
Tissues

32
cDNA Data

10
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase klb

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All Sequences

42
RefSeq

4
UniProt

3
CCDS

CCDS19306.1

Ensembl

ENSMUSG00000029195 (Evidence)
NCBI Gene

83379

			Length	Strain/Species	Flank
genomic	ENSMUSG00000029195	Ensembl Gene Model \| MGI Sequence Detail	35694	C57BL/6J	± kb
transcript	ENSMUST00000031096	Ensembl \| MGI Sequence Detail	3540	Not Applicable
polypeptide	ENSMUSP00000031096	Ensembl \| MGI Sequence Detail	1043	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000009348 beta-klotho

(term hierarchy)
InterPro Domains

IPR001360 Glycoside hydrolase family 1

IPR017853 Glycoside hydrolase superfamily

IPR033132 Glycosyl hydrolases family 1, N-terminal conserved site
GlyGen

Q99N32 13 sites

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All nucleic 12

cDNA 10

Primer pair 2

Microarray probesets 3

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MGI:2141111

Summaries

All 148

Developmental Gene Expression 9

Gene Ontology 8

Phenotypes 85
Earliest

J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
Latest

J:388181 Spann RA, et al., FGF21 signals through hindbrain neurons to alter food intake and energy expenditure during dietary protein restriction. Cell Rep. 2026 Mar 31;45(4):117218

TSS for Klb:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr46456	Chr5:65505671-65505689 (+)	23 bp
Tssr46457	Chr5:65505729-65505749 (+)	82 bp
Tssr46458	Chr5:65505818-65505845 (+)	175 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24