Prrt1 MGI Mouse Gene Detail - MGI:1932118 - proline-rich transmembrane protein 1

Symbol

Prrt1
Name

proline-rich transmembrane protein 1
Synonyms

G5b, NG5, SynDIG4

Feature Type

protein coding gene
IDs

MGI:1932118
NCBI Gene: 260297
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr17:34848507-34852100 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 18.21 cM
Mapping Data

1 experiment

SNPs within 2kb

1 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1932118	protein coding gene	Chr17:34848396-34852108 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023584	protein coding gene	Chr17:34709504-34713162 (+)
A/J	MGP_AJ_G0023546	protein coding gene	Chr17:33527592-33531196 (+)
AKR/J	MGP_AKRJ_G0023511	protein coding gene	Chr17:33945703-33950822 (+)
BALB/cJ	MGP_BALBcJ_G0023550	protein coding gene	Chr17:33675431-33679627 (+)
C3H/HeJ	MGP_C3HHeJ_G0023310	protein coding gene	Chr17:34339780-34343142 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023990	protein coding gene	Chr17:36034886-36038484 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021469	protein coding gene	Chr17:31416144-31419741 (+)
CAST/EiJ	MGP_CASTEiJ_G0022810	protein coding gene	Chr17:34412623-34416914 (+)
CBA/J	MGP_CBAJ_G0023288	protein coding gene	Chr17:37557812-37561408 (+)
DBA/2J	MGP_DBA2J_G0023416	protein coding gene	Chr17:32817841-32821458 (+)
FVB/NJ	MGP_FVBNJ_G0023383	protein coding gene	Chr17:32721968-32725556 (+)
LP/J	MGP_LPJ_G0023494	protein coding gene	Chr17:34981282-34984879 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023406	protein coding gene	Chr17:36445758-36449376 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024033	protein coding gene	Chr17:34254799-34258372 (+)
PWK/PhJ	MGP_PWKPhJ_G0022558	protein coding gene	Chr17:31746834-31750425 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022375	protein coding gene	Chr17:32240271-32245664 (+)
WSB/EiJ	MGP_WSBEiJ_G0022871	protein coding gene	Chr17:34349568-34352929 (+)

Human Ortholog

PRRT1, proline rich transmembrane protein 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PRRT1, proline rich transmembrane protein 1
Synonyms

C6orf31, DSPD1, IFITMD7, NG5, SynDIG4
Links

HGNC:13943

NCBI Gene ID: 80863

neXtProt AC: NX_Q99946

UniProt: Q99946
Chr Location

6p21.32; chr6:32148359-32153083 (-) GRCh38

MGI Vertebrate Homology

Prrt1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PRRT1
Gene Tree

Prrt1

less

Phenotype Summary

7 phenotypes from 1 allele in 2 genetic backgrounds
4 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

2
Targeted

2
Find Mice (IMSR)

9 strains or lines available

Mice homozygous for a knock-out allele exhibit reduced mEPSC, reduced LTP, impaired spatial learning, decreased object recognition and increased exploration.

less

All GO Annotations

16
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

10
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase prrt1

less

All Sequences

44
RefSeq

14
UniProt

3
CCDS

CCDS28653.1

Ensembl

ENSMUSG00000015476 (Evidence)
NCBI Gene

260297

			Length	Strain/Species	Flank
genomic	ENSMUSG00000015476	Ensembl Gene Model \| MGI Sequence Detail	3594	C57BL/6J	± kb
transcript	ENSMUST00000015620	Ensembl \| MGI Sequence Detail	1940	Not Applicable
polypeptide	ENSMUSP00000015620	Ensembl \| MGI Sequence Detail	306	Not Applicable

less

UniProt

3 Sequences
Protein Ontology

PR:000031180 proline-rich transmembrane protein 1

(term hierarchy)
InterPro Domains

IPR007593 CD225/Dispanin family

less

All nucleic 11

Genomic 1

cDNA 10

Microarray probesets 1

Summaries

All 21

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 4
Earliest

J:63110 Allcock RJ, et al., The mouse as a model for the effects of MHC genes on human disease. Immunol Today. 2000 Jul;21(7):328-32
Latest

J:336525 van der Spek SJF, et al., Expression and Interaction Proteomics of GluA1- and GluA3-Subunit-Containing AMPARs Reveal Distinct Protein Composition. Cells. 2022 Nov 17;11(22)

TSS for Prrt1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr144085	Chr17:34848322-34848380 (+)	-156 bp
Tssr144086	Chr17:34848384-34848423 (+)	-103 bp
Tssr144087	Chr17:34848508-34848594 (+)	44 bp
Tssr144088	Chr17:34849444-34849484 (+)	957 bp
Tssr144089	Chr17:34849487-34849503 (+)	988 bp
Tssr144090	Chr17:34849662-34849680 (+)	1,164 bp
Tssr144091	Chr17:34849863-34849913 (+)	1,381 bp
Tssr144092	Chr17:34849916-34849928 (+)	1,415 bp
Tssr144093	Chr17:34849943-34849959 (+)	1,444 bp
Tssr144094	Chr17:34850066-34850121 (+)	1,587 bp
Tssr144095	Chr17:34851277-34851288 (+)	2,776 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23