H1f4 MGI Mouse Gene Detail - MGI:1931527 - H1.4 linker histone, cluster member

Symbol

H1f4
Name

H1.4 linker histone, cluster member
Synonyms

H1-4, H1e, H1f4, H1s-4, H1var2, Hist1h1e

Feature Type

protein coding gene
IDs

MGI:1931527
NCBI Gene: 50709
Member of

Hist1 cluster
Alliance

genome feature page
Transcription Start Sites

5 TSS

Sequence Map

Chr13:23805760-23806541 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 9.83 cM, cytoband A3.2
Mapping Data

2 experiments

SNPs within 2kb

83 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1931527	protein coding gene	Chr13:23804612-23806541 (-)
129S1/SvImJ	ENSMUSG00200029811	protein coding gene	Chr13:20935199-20937128 (-)
A/J	ENSMUSG00195038165	protein coding gene	Chr13:20084357-20086286 (-)
AKR/J	ENSMUSG00220030453	protein coding gene	Chr13:19905537-19907466 (-)
BALB/cJ	ENSMUSG00180019365	protein coding gene	Chr13:20402896-20404825 (-)
C3H/HeJ	ENSMUSG00175031043	protein coding gene	Chr13:20409110-20411039 (-)
C57BL/6NJ	ENSMUSG00215011170	protein coding gene	Chr13:20561824-20563753 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018326	protein coding gene	Chr13:19461791-19462535 (-)
CAST/EiJ	ENSTCUG00005010155	protein coding gene	Chr13:20587649-20589550 (-)
CBA/J	ENSMUSG00210025818	protein coding gene	Chr13:20364409-20366338 (-)
DBA/2J	ENSMUSG00185019735	protein coding gene	Chr13:21186388-21188317 (-)
FVB/NJ	ENSMUSG00205026274	protein coding gene	Chr13:20204820-20206749 (-)
JF1/MsJ	ENSUMUG00000010376	protein coding gene	Chr13:20850617-20852547 (-)
LP/J	ENSMUSG00230015733	protein coding gene	Chr13:30515200-30517128 (-)
NOD/ShiLtJ	ENSMUSG00190032102	protein coding gene	Chr13:20186429-20188357 (-)
NZO/HlLtJ	ENSMUSG00225044829	protein coding gene	Chr13:24298827-24300756 (-)
PWK/PhJ	ENSLUMG00010028876	protein coding gene	Chr13:19748907-19750838 (-)
SPRET/EiJ	ENSMSPG00010017992	protein coding gene	Chr13:19516244-19517170 (-)
WSB/EiJ	ENSIUOG00005032073	protein coding gene	Chr13:19701704-19703633 (-)

Human Ortholog

H1-4, H1.4 linker histone, cluster member

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

H1-4, H1.4 linker histone, cluster member
Synonyms

dJ221C16.5, H1.4, H1E, H1F4, H1s-4, HIST1H1E, RMNS
Links

HGNC:4718

NCBI Gene ID: 3008

UniProt: P10412
Chr Location

6p22.2; chr6:26156329-26157115 (+) GRCh38

MGI Vertebrate Homology

H1f4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: H1-4
Gene Tree

H1f4

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Phenotype Summary

2 phenotypes from 2 alleles in 2 genetic backgrounds
22 phenotypes from multigenic genotypes
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

3
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving H1f4
Incidental Mutations

APF
Find Mice (IMSR)

10 strains or lines available

Homozygotes for targeted null mutations are normal, but Hist1h1e/Hist1h1c double knockout males are significantly smaller than normal. The Hist1h1e/Hist1h1d/Hist1h1e triple knockout is lethal by embryonic day 12.5, and heterozygotes are underrepresented.

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All GO Annotations

58
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

608
Tissues

5
cDNA Data

2
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

29
RefSeq

2
UniProt

1
CCDS

CCDS26355.1

Ensembl

ENSMUSG00000051627 (Evidence)
NCBI Gene

50709

			Length	Strain/Species	Flank
genomic	50709	NCBI Gene Model \| MGI Sequence Detail	782	C57BL/6J	± kb
transcript	NM_015787	RefSeq \| MGI Sequence Detail	782	C57BL/6
polypeptide	P43274	UniProt \| EBI \| MGI Sequence Detail	219	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000008578 histone H1.4

(term hierarchy)
InterPro Domains

IPR005819 Linker histone H1/H5

IPR005818 Linker histone H1/H5, domain H15

IPR036390 Winged helix DNA-binding domain superfamily

IPR036388 Winged helix-like DNA-binding domain superfamily
GlyGen

P43274 1 site, 1 O-linked glycan (1 site)

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All nucleic 5

Genomic 1

cDNA 2

Primer pair 2

Microarray probesets 2

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MGI:6324974

Summaries

All 64

Developmental Gene Expression 4

Gene Ontology 13

Phenotypes 20
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:387965 Luo YN, et al., Tracking mobilization uncovers an evolutionarily conserved mechanism in suppressing mobile genetic elements. Mol Cell. 2026 Jun 18;86(12):2263-2280.e10

TSS for H1f4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr121733	Chr13:23806531-23806546 (-)	2 bp
Tssr121732	Chr13:23806000-23806089 (-)	496 bp
Tssr121731	Chr13:23805973-23805986 (-)	561 bp
Tssr121730	Chr13:23805920-23805972 (-)	595 bp
Tssr121729	Chr13:23805872-23805914 (-)	648 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24