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Parva Gene Detail
Summary
  • Symbol
    Parva
  • Name
    parvin, alpha
  • Synonyms
    2010012A22Rik, 5430400F08Rik, actopaxin, CH-ILKBP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1931144
    NCBI Gene: 57342
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:112027102-112190899 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 58.76 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4743 from dbSNP Build 142
  • Strain Annotations
    30
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1931144
 protein coding gene Chr7:112026712-112190899 (+)
129S1/SvImJ ENSMUSG00200027717
 protein coding gene Chr7:98659597-98728895 (+)
129S1/SvImJ ENSMUSGG00200054937
 protein coding gene Chr7:98572267-98641128 (+)
A/J ENSMUSGG00195055350
 protein coding gene Chr7:103075911-103144791 (+)
A/J ENSMUSG00195032229
 protein coding gene Chr7:103163270-103232593 (+)
AKR/J ENSMUSG00220033749
 protein coding gene Chr7:96566174-96635481 (+)
AKR/J ENSMUSGG00220054580
 protein coding gene Chr7:96478846-96547707 (+)
BALB/cJ ENSMUSG00180042810
 protein coding gene Chr7:99831326-99900642 (+)
BALB/cJ ENSMUSGG00180055067
 protein coding gene Chr7:99743989-99812854 (+)
C3H/HeJ ENSMUSG00175044728
 protein coding gene Chr7:100467132-100536434 (+)
C3H/HeJ ENSMUSGG00175054568
 protein coding gene Chr7:100379803-100448666 (+)
C57BL/6NJ ENSMUSGG00215055774
 protein coding gene Chr7:99684554-99757931 (+)
C57BL/6NJ ENSMUSG00215048641
 protein coding gene Chr7:99776363-99845633 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030336
 protein coding gene Chr7:114709740-114872084 (+)
CAST/EiJ ENSTCUG00005043253
 protein coding gene Chr7:103173965-103239963 (+)
CBA/J ENSMUSG00210043008
 protein coding gene Chr7:100294095-100363400 (+)
CBA/J ENSMUSGG00210054498
 protein coding gene Chr7:100206760-100275627 (+)
DBA/2J ENSMUSGG00185057700
 protein coding gene Chr7:104556926-104625789 (+)
DBA/2J ENSMUSG00185020680
 protein coding gene Chr7:104644259-104713560 (+)
FVB/NJ ENSMUSGG00205054567
 protein coding gene Chr7:100166948-100240336 (+)
FVB/NJ ENSMUSG00205040073
 protein coding gene Chr7:100258779-100328052 (+)
JF1/MsJ ENSUMUG00000039387
 protein coding gene Chr7:109684140-109750692 (+)
LP/J ENSMUSG00230046169
 protein coding gene Chr7:110745272-110814570 (+)
LP/J ENSMUSGG00230055870
 protein coding gene Chr7:110657944-110726802 (+)
NOD/ShiLtJ ENSMUSG00190045340
 protein coding gene Chr7:100455686-100524982 (+)
NOD/ShiLtJ ENSMUSGG00190054984
 protein coding gene Chr7:100368341-100437215 (+)
NZO/HlLtJ ENSMUSG00225015888
 protein coding gene Chr7:108902127-109059608 (+)
PWK/PhJ ENSLUMG00010032341
 protein coding gene Chr7:98819178-98885604 (+)
SPRET/EiJ ENSMSPG00010036767
 protein coding gene Chr7:99988491-100053174 (+)
WSB/EiJ ENSIUOG00005044304
 protein coding gene Chr7:101109343-101178636 (+)



Homology
more
  • Human Ortholog
    PARVA, parvin alpha
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PARVA, parvin alpha
  • Synonyms
    CH-ILKBP, MXRA2
  • Links
    NCBI Gene ID: 55742
    UniProt: Q9NVD7

  • Chr Location
    11p15.3; chr11:12376436-12535356 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 2 alleles in 2 genetic backgrounds
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Embryos homozygous for a null allele are growth retarded and die prior to E14.5 exhibiting abnormal cardiac morphogenesis, severe vascular defects, edema, microaneurysms, hemorrhage, and severe kidney dysgenesis or agenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    54
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    728
  • Tissues
    117
  • cDNA Data
    185
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 57342 NCBI Gene Model | MGI Sequence Detail 163798 C57BL/6J ±  kb
    transcript NM_020606 RefSeq | MGI Sequence Detail 4265 C57BL/6  
    polypeptide Q9EPC1 UniProt | EBI | MGI Sequence Detail 372 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 188
      cDNA 185
      Primer pair 3
      Antibodies 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1914044, MGI:1923778, MGI:2141883, MGI:2142158
    References
    more
    • Summaries
      All 79
      Developmental Gene Expression 11
      Gene Ontology 17
      Phenotypes 26
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:375911 Rogg M, et al., Arp2/3-dependent regulation of ciliogenesis governs adaptive distal tubular epithelial cell states in kidney disease. Sci Adv. 2025 Nov 28;11(48):eady1623
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory