Parva MGI Mouse Gene Detail - MGI:1931144

Symbol

Parva
Name

parvin, alpha
Synonyms

2010012A22Rik, 5430400F08Rik, actopaxin, CH-ILKBP

Feature Type

protein coding gene
IDs

MGI:1931144
NCBI Gene: 57342
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr7:112026913-112190895 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 58.76 cM
Mapping Data

2 experiments

SNPs within 2kb

2003 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1931144	protein coding gene	Chr7:112026712-112190899 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032870	protein coding gene	Chr7:115999277-116177830 (+)
A/J	MGP_AJ_G0032853	protein coding gene	Chr7:113113859-113274928 (+)
AKR/J	MGP_AKRJ_G0032785	protein coding gene	Chr7:115960500-116119585 (+)
BALB/cJ	MGP_BALBcJ_G0032858	protein coding gene	Chr7:112807791-112971225 (+)
C3H/HeJ	MGP_C3HHeJ_G0032568	protein coding gene	Chr7:115951804-116120615 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033364	protein coding gene	Chr7:120740704-120906906 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030336	protein coding gene	Chr7:114709740-114872084 (+)
CAST/EiJ	MGP_CASTEiJ_G0031896	protein coding gene	Chr7:107565895-107730840 (+)
CBA/J	MGP_CBAJ_G0032541	protein coding gene	Chr7:124712809-124896719 (+)
DBA/2J	MGP_DBA2J_G0032693	protein coding gene	Chr7:111196720-111357896 (+)
FVB/NJ	MGP_FVBNJ_G0032646	protein coding gene	Chr7:111045600-111205012 (+)
LP/J	MGP_LPJ_G0032787	protein coding gene	Chr7:117512352-117680403 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032678	protein coding gene	Chr7:126317969-126485911 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033384	protein coding gene	Chr7:114959629-115121910 (+)
PWK/PhJ	MGP_PWKPhJ_G0031603	protein coding gene	Chr7:104035915-104189865 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031451	protein coding gene	Chr7:101708554-101874991 (+)
WSB/EiJ	MGP_WSBEiJ_G0032009	protein coding gene	Chr7:115820809-115988570 (+)

Human Ortholog

PARVA, parvin alpha

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PARVA, parvin alpha
Synonyms

CH-ILKBP, MXRA2
Links

HGNC:14652

NCBI Gene ID: 55742

neXtProt AC: NX_Q9NVD7

UniProt: Q9NVD7
Chr Location

11p15.3; chr11:12376441-12535356 (+) GRCh38.p7

Alliance of Genome Resources

Parva stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PARVA
Protein SuperFamily

Parvin
Gene Tree

Parva

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Phenotype Summary

20 phenotypes from 1 allele in 1 genetic background
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Endonuclease-mediated

2
Gene trapped

5
Radiation induced

1
Targeted

6
Genomic Mutations

1 involving Parva
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Embryos homozygous for a null allele are growth retarded and die prior to E14.5 exhibiting abnormal cardiac morphogenesis, severe vascular defects, edema, microaneurysms, hemorrhage, and severe kidney dysgenesis or agenesis.

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All GO Annotations

41
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

834
Tissues

116
cDNA Data

185
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN parvab

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Parva interacts with 412 markers (Mir1a-1, Mir1a-2, Mir7-2, ...) View All

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All Sequences

75
RefSeq

6
UniProt

4
CCDS

CCDS40091.1

Ensembl

ENSMUSG00000030770 (Evidence)
NCBI Gene

57342

			Length	Strain/Species	Flank
genomic	57342	NCBI Gene Model \| MGI Sequence Detail	163983	C57BL/6J	± kb
transcript	NM_020606	RefSeq \| MGI Sequence Detail	4265	C57BL/6
polypeptide	Q9EPC1	UniProt \| EBI \| MGI Sequence Detail	372	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000012303 alpha-parvin

(term hierarchy)
InterPro Domains

IPR001715 Calponin homology domain

IPR036872 CH domain superfamily

IPR028433 Parvin

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All nucleic 188

cDNA 185

Primer pair 3

Microarray probesets 8

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MGI:1914044, MGI:1923778, MGI:2141883, MGI:2142158

Summaries

All 63

Developmental Gene Expression 10

Gene Ontology 13

Phenotypes 20
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:327276 Thievessen I, et al., The focal adhesion protein beta-parvin controls cardiomyocyte shape and sarcomere assembly in response to mechanical load. Curr Biol. 2022 Jul 25;32(14):3033-3047.e9

TSS for Parva:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr68573	Chr7:112026232-112026245 (+)	-674 bp
Tssr68574	Chr7:112026878-112026887 (+)	-30 bp
Tssr68575	Chr7:112026922-112026925 (+)	11 bp
Tssr68576	Chr7:112027073-112027089 (+)	168 bp
Tssr68577	Chr7:112027092-112027159 (+)	213 bp
Tssr68579	Chr7:112099219-112099221 (+)	72,307 bp
Tssr68580	Chr7:112118819-112118857 (+)	91,925 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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