Marchf7 MGI Mouse Gene Detail - MGI:1931053 - membrane associated ring-CH-type finger 7

Symbol

Marchf7
Name

membrane associated ring-CH-type finger 7
Synonyms

Axot, Gtrgeo17, March7

Feature Type

protein coding gene
IDs

MGI:1931053
NCBI Gene: 57438
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr2:60040086-60079562 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 34.46 cM, cytoband C3
Mapping Data

3 experiments

SNPs within 2kb

117 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1931053	protein coding gene	Chr2:60040086-60081020 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025759	protein coding gene	Chr2:59790662-59832123 (+)
A/J	MGP_AJ_G0025735	protein coding gene	Chr2:57484832-57525986 (+)
AKR/J	MGP_AKRJ_G0025705	protein coding gene	Chr2:59053374-59097063 (+)
BALB/cJ	MGP_BALBcJ_G0025730	protein coding gene	Chr2:57588741-57629877 (+)
C3H/HeJ	MGP_C3HHeJ_G0025491	protein coding gene	Chr2:59168683-59209477 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026177	protein coding gene	Chr2:61553076-61595277 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023581	protein coding gene	Chr2:55088585-55110243 (+)
CAST/EiJ	MGP_CASTEiJ_G0024955	protein coding gene	Chr2:59207664-59249784 (+)
CBA/J	MGP_CBAJ_G0025471	protein coding gene	Chr2:63896368-63937092 (+)
DBA/2J	MGP_DBA2J_G0025602	protein coding gene	Chr2:57087485-57129099 (+)
FVB/NJ	MGP_FVBNJ_G0025564	protein coding gene	Chr2:56636794-56677781 (+)
LP/J	MGP_LPJ_G0025690	protein coding gene	Chr2:59642737-59683458 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025595	protein coding gene	Chr2:65508783-65551227 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026234	protein coding gene	Chr2:59090111-59132239 (+)
PWK/PhJ	MGP_PWKPhJ_G0024696	protein coding gene	Chr2:56938230-56982929 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024503	protein coding gene	Chr2:59161356-59200047 (+)
WSB/EiJ	MGP_WSBEiJ_G0025023	protein coding gene	Chr2:59385799-59427418 (+)

Human Ortholog

MARCHF7, membrane associated ring-CH-type finger 7

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MARCHF7, membrane associated ring-CH-type finger 7
Synonyms

AXO, AXOT, MARCH7, MARCH-VII, RNF177
Links

HGNC:17393

NCBI Gene ID: 64844

neXtProt AC: NX_Q9H992

UniProt: Q9H992
Chr Location

2q24.2; chr2:159712457-159768583 (+) GRCh38.p7

Alliance of Genome Resources

Marchf7 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: MARCHF7
Gene Tree

Marchf7

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

67
Chemically induced (other)

1
Gene trapped

60
Targeted

6
Genomic Mutations

1 involving Marchf7
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

57 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice show premature neural degeneration and defective development of the corpus callosum. Both T cell proliferation and T cell-derived leukaemia inhibitory factor are increased.

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All GO Annotations

26
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

711
Tissues

5
cDNA Data

215
Literature Summary

4

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase marchf7

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Marchf7 interacts with 271 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

79
RefSeq

24
UniProt

2
CCDS

CCDS16057.1

Ensembl

ENSMUSG00000026977 (Evidence)
NCBI Gene

57438

			Length	Strain/Species	Flank
genomic	57438	NCBI Gene Model \| MGI Sequence Detail	39477	C57BL/6J	± kb
transcript	NM_020575	RefSeq \| MGI Sequence Detail	2719	C57BL/6
polypeptide	Q9WV66	UniProt \| EBI \| MGI Sequence Detail	693	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000010181 E3 ubiquitin-protein ligase MARCHF7

(term hierarchy)
EC

2.3.2.27
InterPro Domains

IPR011016 Zinc finger, RING-CH-type

IPR013083 Zinc finger, RING/FYVE/PHD-type

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All nucleic 216

cDNA 215

Primer pair 1

Microarray probesets 10

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MGI:894656

Summaries

All 41

Developmental Gene Expression 4

Gene Ontology 6

Phenotypes 11
Earliest

J:40477 Baker RK, et al., In vitro preselection of gene-trapped embryonic stem cell clones for characterizing novel developmentally regulated genes in the mouse. Dev Biol. 1997 May 15;185(2):201-14
Latest

J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

TSS for Marchf7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr17878	Chr2:60038737-60038765 (+)	-1,335 bp
Tssr17879	Chr2:60040237-60040310 (+)	188 bp
Tssr17880	Chr2:60040983-60041008 (+)	910 bp
Tssr17881	Chr2:60042322-60042331 (+)	2,241 bp
Tssr17882	Chr2:60053410-60053418 (+)	13,328 bp
Tssr17884	Chr2:60078552-60078571 (+)	38,476 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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