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Nectin3 Gene Detail
Summary
  • Symbol
    Nectin3
  • Name
    nectin cell adhesion molecule 3
  • Synonyms
    2610301B19Rik, 3000002N23Rik, 4921513D19Rik, nectin-3, Pvrl3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1930171
    NCBI Gene: 58998
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:46208069-46318888 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 30.48 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3158 from dbSNP Build 142
  • Strain Annotations
    26
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1930171
 protein coding gene Chr16:46208028-46318898 (-)
129S1/SvImJ ENSMUSGG00200054652
 protein coding gene Chr16:43153146-43203273 (-)
129S1/SvImJ ENSMUSG00200021385
 protein coding gene Chr16:43100548-43116830 (-)
A/J ENSMUSGG00195055334
 protein coding gene Chr16:42753602-42803426 (-)
A/J ENSMUSG00195003357
 protein coding gene Chr16:42701289-42717656 (-)
AKR/J ENSMUSG00220021441
 protein coding gene Chr16:43060082-43076449 (-)
AKR/J ENSMUSGG00220054602
 protein coding gene Chr16:43112395-43162219 (-)
BALB/cJ ENSMUSGG00180055271
 protein coding gene Chr16:42958496-43008319 (-)
BALB/cJ ENSMUSG00180026529
 protein coding gene Chr16:42906182-42922549 (-)
C3H/HeJ ENSMUSGG00175055062
 protein coding gene Chr16:43224470-43274514 (-)
C3H/HeJ ENSMUSG00175025304
 protein coding gene Chr16:43173273-43188394 (-)
C57BL/6NJ ENSMUSG00215005753
 protein coding gene Chr16:42999915-43016282 (-)
C57BL/6NJ ENSMUSGG00215055558
 protein coding gene Chr16:43052228-43102074 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020789
 protein coding gene Chr16:43525193-43637858 (-)
CAST/EiJ no annotation
CBA/J ENSMUSGG00210054897
 protein coding gene Chr16:43246452-43296495 (-)
CBA/J ENSMUSG00210016275
 protein coding gene Chr16:43195254-43210375 (-)
DBA/2J ENSMUSGG00185057533
 protein coding gene Chr16:43138106-43187930 (-)
DBA/2J ENSMUSG00185010192
 protein coding gene Chr16:43085794-43102161 (-)
FVB/NJ ENSMUSG00205010921
 protein coding gene Chr16:42970005-42986403 (-)
FVB/NJ ENSMUSGG00205054270
 protein coding gene Chr16:43022356-43072333 (-)
JF1/MsJ no annotation
LP/J ENSMUSG00230025882
 protein coding gene Chr16:45652270-45668637 (-)
LP/J ENSMUSGG00230055375
 protein coding gene Chr16:45704583-45754424 (-)
NOD/ShiLtJ ENSMUSGG00190054961
 protein coding gene Chr16:43148870-43198708 (-)
NOD/ShiLtJ ENSMUSG00190017840
 protein coding gene Chr16:43096563-43112930 (-)
NZO/HlLtJ ENSMUSG00225028310
 protein coding gene Chr16:48744021-48760388 (-)
NZO/HlLtJ ENSMUSGG00225055230
 protein coding gene Chr16:48796332-48846174 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    NECTIN3, nectin cell adhesion molecule 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NECTIN3, nectin cell adhesion molecule 3
  • Synonyms
    CD113, CDW113, NECTIN-3, PPR3, PRR3, PVRL3, PVRR3
  • Links
    NCBI Gene ID: 25945
    UniProt: Q9NQS3

  • Chr Location
    3q13.13; chr3:111070071-111275563 (+)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 1 allele in 3 genetic backgrounds
    10 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit male infertility and eye abnormalities including microphthalmia, absent vitreous body, abnormal ciliary body, retinal layers, and lenses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    47
  • GO References
    22
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    815
  • Tissues
    115
  • cDNA Data
    24
  • Literature Summary
    36
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022656 Ensembl Gene Model | MGI Sequence Detail 110820 C57BL/6J ±  kb
    transcript ENSMUST00000023334 Ensembl | MGI Sequence Detail 3062 Not Applicable  
    polypeptide ENSMUSP00000023334 Ensembl | MGI Sequence Detail 549 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      cDNA 24
      Primer pair 2
      Antibodies 5

      Microarray probesets 12
    Other
    Accession IDs
    less
    MGI:1914402, MGI:1918158, MGI:1919634, MGI:2146332, MGI:2146547, MGI:2146649
    References
    more
    • Summaries
      All 102
      Developmental Gene Expression 36
      Diseases 1
      Gene Ontology 22
      Phenotypes 19
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:365965 Clancy S, et al., Rac1 and Nectin3 are essential for planar cell polarity-directed axon guidance in the peripheral auditory system. Development. 2025 Apr 15;152(8)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory