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Klk11 Gene Detail
Summary
  • Symbol
    Klk11
  • Name
    kallikrein related-peptidase 11
  • Synonyms
    2310015I08Rik, hippostasin, Prss20, TLSP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929977
    NCBI Gene: 56538
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:43424041-43428687 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 28.26 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    168 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929977
 protein coding gene Chr7:43424028-43428687 (+)
129S1/SvImJ ENSMUSG00200028816
 protein coding gene Chr7:31009911-31014570 (+)
A/J ENSMUSG00195047909
 protein coding gene Chr7:35050061-35054720 (+)
AKR/J ENSMUSG00220043804
 protein coding gene Chr7:29348162-29352821 (+)
BALB/cJ ENSMUSG00180038121
 protein coding gene Chr7:31925566-31930225 (+)
C3H/HeJ ENSMUSG00175038734
 protein coding gene Chr7:32445855-32450515 (+)
C57BL/6NJ ENSMUSG00215043999
 protein coding gene Chr7:31715685-31720344 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029637
 protein coding gene Chr7:45038607-45043191 (+)
CAST/EiJ ENSTCUG00005046359
 protein coding gene Chr7:35443305-35447934 (+)
CBA/J ENSMUSG00210046530
 protein coding gene Chr7:32822598-32827257 (+)
DBA/2J ENSMUSG00185038064
 protein coding gene Chr7:36695866-36700505 (+)
FVB/NJ ENSMUSG00205046166
 protein coding gene Chr7:32367814-32372473 (+)
JF1/MsJ ENSUMUG00000046184
 protein coding gene Chr7:41182895-41187534 (+)
LP/J ENSMUSG00230049979
 protein coding gene Chr7:42130786-42135445 (+)
NOD/ShiLtJ ENSMUSG00190048232
 protein coding gene Chr7:32689513-32694172 (+)
NZO/HlLtJ ENSMUSG00225016865
 protein coding gene Chr7:40341785-40346444 (+)
PWK/PhJ ENSLUMG00010037435
 protein coding gene Chr7:31617301-31621933 (+)
SPRET/EiJ ENSMSPG00010028262
 protein coding gene Chr7:31408799-31413420 (+)
WSB/EiJ ENSIUOG00005028899
 protein coding gene Chr7:33259859-33264518 (+)



Homology
more
  • Human Ortholog
    KLK11, kallikrein related peptidase 11
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KLK11, kallikrein related peptidase 11
  • Synonyms
    IEKD, PRSS20, TLSP
  • Links
    NCBI Gene ID: 11012
    UniProt: Q9UBX7

  • Chr Location
    19q13.41; chr19:51022216-51028039 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygosity for the p.G44E mutation leads to hyperkeratosis and scaly skin.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56538 NCBI Gene Model | MGI Sequence Detail 4647 C57BL/6J ±  kb
    transcript NM_001177373 RefSeq | MGI Sequence Detail 1319 C57BL/6  
    polypeptide Q9QYN3 UniProt | EBI | MGI Sequence Detail 276 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 10

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1913805
    References
    more
    • Summaries
      All 31
      Gene Ontology 5
      Phenotypes 9
    • Earliest
      J:65795 Mitsui S, et al., cDNA cloning and tissue-specific splicing variants of mouse hippostasin/TLSP (PRSS20)(1). Biochim Biophys Acta. 2000 Nov 15;1494(1-2):206-10
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory