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Ndufa1 Gene Detail
Summary
  • Symbol
    Ndufa1
  • Name
    NADH:ubiquinone oxidoreductase subunit A1
  • Synonyms
    1810049F12Rik, MWFE
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929511
    NCBI Gene: 54405
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:36451241-36454816 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 21.61 cM, cytoband A2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    113 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929511
 protein coding gene ChrX:36451241-36454891 (-)
129S1/SvImJ ENSMUSG00200021526
 protein coding gene ChrX:20561982-20565557 (-)
A/J ENSMUSG00195024321
 protein coding gene ChrX:23232607-23236182 (-)
AKR/J ENSMUSG00220023650
 protein coding gene ChrX:20344068-20347644 (-)
BALB/cJ ENSMUSG00180012325
 protein coding gene ChrX:20790947-20794523 (-)
C3H/HeJ ENSMUSG00175023317
 protein coding gene ChrX:23938258-23941833 (-)
C57BL/6NJ ENSMUSG00215020264
 protein coding gene ChrX:20984289-20987865 (-)
CAROLI/EiJ no annotation
CAST/EiJ ENSTCUG00005030530
 protein coding gene ChrX:22882357-22885930 (-)
CBA/J ENSMUSG00210032508
 protein coding gene ChrX:21228952-21232527 (-)
DBA/2J ENSMUSG00185024334
 protein coding gene ChrX:31809850-31813425 (-)
FVB/NJ ENSMUSG00205017375
 protein coding gene ChrX:19904811-19908386 (-)
JF1/MsJ ENSUMUG00000029879
 protein coding gene ChrX:50930534-50934075 (-)
LP/J ENSMUSG00230011217
 protein coding gene ChrX:38302056-38305631 (-)
NOD/ShiLtJ ENSMUSG00190021773
 protein coding gene ChrX:20503068-20506643 (-)
NZO/HlLtJ ENSMUSG00225039225
 protein coding gene ChrX:43508513-43512088 (-)
PWK/PhJ ENSLUMG00010034572
 protein coding gene ChrX:20635028-20638567 (-)
SPRET/EiJ ENSMSPG00010015603
 protein coding gene ChrX:21857368-21860881 (-)
WSB/EiJ ENSIUOG00005036355
 protein coding gene ChrX:21418975-21422550 (-)



Homology
more
  • Human Ortholog
    NDUFA1, NADH:ubiquinone oxidoreductase subunit A1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NDUFA1, NADH:ubiquinone oxidoreductase subunit A1
  • Synonyms
    CI-MWFE, MC1DN12, MWFE, ZNF183
  • Links
    NCBI Gene ID: 4694
    UniProt: O15239

  • Chr Location
    Xq24; chrX:119871796-119876689 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Ndufa1 mouse models; 1 with human NDUFA1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Males hemizygous for an S55A amino acid substitution show hypoactivity, decreased food intake, basal metabolism, respiratory exchange ratio, oxygen consumption, energy expenditure and heme levels, Purkinje cell degeneration and premature death, whereas homozygous females show an extended lifespan.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    714
  • Tissues
    98
  • cDNA Data
    150
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000016427 Ensembl Gene Model | MGI Sequence Detail 3576 C57BL/6J ±  kb
    transcript ENSMUST00000016571 Ensembl | MGI Sequence Detail 419 Not Applicable  
    polypeptide ENSMUSP00000016571 Ensembl | MGI Sequence Detail 70 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 151
      cDNA 151

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1923962
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 8
      Diseases 1
      Gene Ontology 10
      Phenotypes 4
    • Earliest
      J:66313 Frattini A, et al., Identification of a new member (ZNF183) of the Ring finger gene family in Xq24-25. Gene. 1997 Jun 19;192(2):291-8
    • Latest
      J:363294 Wang S, et al., SOX4 facilitates brown fat development and maintenance through EBF2-mediated thermogenic gene program in mice. Cell Death Differ. 2025 Mar;32(3):447-465
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory