Arl6ip6 MGI Mouse Gene Detail - MGI:1929507 - ADP-ribosylation factor-like 6 interacting protein 6

Symbol

Arl6ip6
Name

ADP-ribosylation factor-like 6 interacting protein 6
Synonyms

2310057C01Rik, 2610529A11Rik, Aip-6

Feature Type

protein coding gene
IDs

MGI:1929507
NCBI Gene: 65103
Alliance

genome feature page
Transcription Start Sites

3 TSS

Sequence Map

Chr2:53082096-53109233 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 30.69 cM, cytoband C1
Mapping Data

3 experiments

SNPs within 2kb

748 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1929507	protein coding gene	Chr2:53081738-53109233 (+)
129S1/SvImJ	ENSMUSG00200010748	protein coding gene	Chr2:50079615-50107066 (+)
A/J	ENSMUSG00195009798	protein coding gene	Chr2:50227684-50255132 (+)
AKR/J	ENSMUSG00220020663	protein coding gene	Chr2:50352134-50379586 (+)
BALB/cJ	ENSMUSG00180020585	protein coding gene	Chr2:50211195-50238333 (+)
C3H/HeJ	ENSMUSG00175013174	protein coding gene	Chr2:50251798-50279245 (+)
C57BL/6NJ	ENSMUSG00215009752	protein coding gene	Chr2:50253823-50280956 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023562	protein coding gene	Chr2:48507141-48536256 (+)
CAST/EiJ	ENSTCUG00005001359	protein coding gene	Chr2:49753370-49780532 (+)
CBA/J	ENSMUSG00210031516	protein coding gene	Chr2:50264871-50292319 (+)
DBA/2J	ENSMUSG00185002568	protein coding gene	Chr2:50132375-50159823 (+)
FVB/NJ	ENSMUSG00205001771	protein coding gene	Chr2:49929078-49956527 (+)
JF1/MsJ	ENSUMUG00000000465	protein coding gene	Chr2:49956617-49984083 (+)
LP/J	ENSMUSG00230001685	protein coding gene	Chr2:52032340-52059473 (+)
NOD/ShiLtJ	ENSMUSG00190001963	protein coding gene	Chr2:50179898-50207348 (+)
NZO/HlLtJ	ENSMUSG00225000405	protein coding gene	Chr2:59743472-59770604 (+)
PWK/PhJ	ENSLUMG00010004126	protein coding gene	Chr2:50100328-50127795 (+)
SPRET/EiJ	ENSMSPG00010011804	protein coding gene	Chr2:51101546-51136273 (+)
WSB/EiJ	ENSIUOG00005001222	protein coding gene	Chr2:50201554-50228691 (+)

Human Ortholog

ARL6IP6, ARF like GTPase 6 interacting protein 6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ARL6IP6, ARF like GTPase 6 interacting protein 6
Synonyms

AIP-6, AIP6, PFAAP1
Links

HGNC:24048

NCBI Gene ID: 151188

UniProt: Q8N6S5
Chr Location

2q23.3; chr2:152717647-152762396 (+) GRCh38

MGI Vertebrate Homology

Arl6ip6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ARL6IP6
Gene Tree

Arl6ip6

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

16
Genomic Mutations

1 involving Arl6ip6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

25 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

4
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

648
Tissues

5
cDNA Data

74
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase arl6ip6

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All Sequences

44
RefSeq

2
UniProt

2
CCDS

CCDS16039.1

Ensembl

ENSMUSG00000026960 (Evidence)
NCBI Gene

65103

			Length	Strain/Species	Flank
genomic	65103	NCBI Gene Model \| MGI Sequence Detail	27138	C57BL/6J	± kb
transcript	NM_022989	RefSeq \| MGI Sequence Detail	2553	C57BL/6
polypeptide	Q8BH07	UniProt \| EBI \| MGI Sequence Detail	226	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000004294 ADP-ribosylation factor-like protein 6-interacting protein 6

(term hierarchy)
InterPro Domains

IPR029383 ADP-ribosylation factor-like protein 6-interacting protein 6
GlyGen

Q8BH07 1 site

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All nucleic 74

cDNA 74

Microarray probesets 5

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MGI:1914875, MGI:1922841

Summaries

All 39

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 11
Earliest

J:62458 Ingley E, et al., A novel ADP-ribosylation like factor (ARL-6), interacts with the protein-conducting channel SEC61beta subunit. FEBS Lett. 1999 Oct 1;459(1):69-74
Latest

J:351297 Ge T, et al., Coiled-coil domain containing 159 is required for spermatid head and tail assembly in mice. Biol Reprod. 2024 May 9;110(5):877-894

TSS for Arl6ip6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr17758	Chr2:53082079-53082112 (+)	0 bp
Tssr17759	Chr2:53082113-53082140 (+)	31 bp
Tssr17760	Chr2:53082178-53082189 (+)	88 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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