Dstn MGI Mouse Gene Detail - MGI:1929270

Symbol

Dstn
Name

destrin
Synonyms

2610043P17Rik, ADF, corn1, sid23p

Feature Type

protein coding gene
IDs

MGI:1929270
NCBI Gene: 56431
Alliance

genome feature page
Transcription Start Sites

5 TSS

Sequence Map

Chr2:143757251-143785244 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 70.89 cM, cytoband H1
Mapping Data

7 experiments

SNPs within 2kb

852 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1929270	protein coding gene	Chr2:143757240-143785244 (+)
129S1/SvImJ	ENSMUSG00200007259	protein coding gene	Chr2:140832107-140859720 (+)
A/J	ENSMUSG00195015725	protein coding gene	Chr2:141008718-141036698 (+)
AKR/J	ENSMUSG00220038180	protein coding gene	Chr2:140542578-140570583 (+)
BALB/cJ	ENSMUSG00180028273	protein coding gene	Chr2:140657373-140685376 (+)
C3H/HeJ	ENSMUSG00175031352	protein coding gene	Chr2:141204576-141232585 (+)
C57BL/6NJ	ENSMUSG00215017509	protein coding gene	Chr2:140713373-140741377 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024376	protein coding gene	Chr2:136181602-136209361 (+)
CAST/EiJ	ENSTCUG00005010644	protein coding gene	Chr2:139865840-139893972 (+)
CBA/J	ENSMUSG00210037879	protein coding gene	Chr2:141123832-141151837 (+)
DBA/2J	ENSMUSG00185040819	protein coding gene	Chr2:140710381-140738000 (+)
FVB/NJ	ENSMUSG00205019931	protein coding gene	Chr2:139887733-139915708 (+)
JF1/MsJ	ENSUMUG00000020682	protein coding gene	Chr2:140511114-140538736 (+)
LP/J	ENSMUSG00230008877	protein coding gene	Chr2:142414605-142442220 (+)
NOD/ShiLtJ	ENSMUSG00190028562	protein coding gene	Chr2:140796083-140824062 (+)
NZO/HlLtJ	ENSMUSG00225000845	protein coding gene	Chr2:150402620-150430225 (+)
PWK/PhJ	ENSLUMG00010039105	protein coding gene	Chr2:140550411-140581203 (+)
SPRET/EiJ	ENSMSPG00010025535	protein coding gene	Chr2:143040820-143068153 (+)
WSB/EiJ	ENSIUOG00005022566	protein coding gene	Chr2:140581152-140609117 (+)

Human Ortholog

DSTN, destrin, actin depolymerizing factor

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DSTN, destrin, actin depolymerizing factor
Synonyms

ACTDP, ADF, bA462D18.2, HEL32
Links

HGNC:15750

NCBI Gene ID: 11034

UniProt: P60981
Chr Location

20p12.1; chr20:17569152-17609919 (+) GRCh38

MGI Vertebrate Homology

Dstn stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DSTN
Gene Tree

Dstn

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Phenotype Summary

14 phenotypes from 4 alleles in 6 genetic backgrounds
7 phenotypes from multigenic genotypes
1 images
45 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

81
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

70
Radiation induced

1
Spontaneous

2
Targeted

4
Genomic Mutations

2 involving Dstn
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

45 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice carrying mutations at this locus develop irregular thickening of the corneal epithelium.

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All GO Annotations

26
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

944
Tissues

83
cDNA Data

14
Literature Summary

13

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dstn

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All Sequences

39
RefSeq

2
UniProt

2
CCDS

CCDS16812.1

Ensembl

ENSMUSG00000015932 (Evidence)
NCBI Gene

56431

			Length	Strain/Species	Flank
genomic	56431	NCBI Gene Model \| MGI Sequence Detail	27994	C57BL/6J	± kb
transcript	NM_019771	RefSeq \| MGI Sequence Detail	1918	Not Specified
polypeptide	Q9R0P5	UniProt \| EBI \| MGI Sequence Detail	165	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000006713 destrin

(term hierarchy)
InterPro Domains

IPR002108 Actin-depolymerising factor homology domain

IPR017904 ADF/Cofilin

IPR029006 ADF-H/Gelsolin-like domain superfamily
GlyGen

Q9R0P5 1 site, 1 O-linked glycan (1 site)

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All nucleic 18

cDNA 15

Primer pair 1

Other 2

Antibodies 2

Microarray probesets 4

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MGD-MRK-33921, MGI:106229, MGI:1917157, MGI:2139214

Summaries

All 91

Developmental Gene Expression 13

Gene Ontology 9

Phenotypes 45
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:351187 Khudayberdiev S, et al., The actin-binding protein CAP1 represses MRTF-SRF-dependent gene expression in mouse cerebral cortex. Sci Signal. 2024 May 7;17(835):eadj0032

TSS for Dstn:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr20509	Chr2:143757193-143757257 (+)	-26 bp
Tssr20510	Chr2:143757423-143757455 (+)	188 bp
Tssr20511	Chr2:143757461-143757488 (+)	224 bp
Tssr20512	Chr2:143761126-143761131 (+)	3,878 bp
Tssr20513	Chr2:143778173-143778177 (+)	20,924 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24