Tmed2 MGI Mouse Gene Detail - MGI:1929269 - transmembrane p24 trafficking protein 2

Symbol

Tmed2
Name

transmembrane p24 trafficking protein 2
Synonyms

1110032D12Rik, 1810020N21Rik, p24beta1, Sid394

Feature Type

protein coding gene
IDs

MGI:1929269
NCBI Gene: 56334
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr5:124678835-124688566 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 63.65 cM
Mapping Data

2 experiments

SNPs within 2kb

258 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1929269	protein coding gene	Chr5:124678758-124688569 (+)
129S1/SvImJ	ENSMUSG00200024109	protein coding gene	Chr5:118401027-118410838 (+)
A/J	ENSMUSG00195011236	protein coding gene	Chr5:117922627-117932438 (+)
AKR/J	ENSMUSG00220037554	protein coding gene	Chr5:117433058-117442869 (+)
BALB/cJ	ENSMUSG00180036453	protein coding gene	Chr5:118037533-118047343 (+)
C3H/HeJ	ENSMUSG00175024908	protein coding gene	Chr5:120039254-120049066 (+)
C57BL/6NJ	ENSMUSG00215017324	protein coding gene	Chr5:118087912-118097723 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027754	protein coding gene	Chr5:117552052-117561936 (+)
CAST/EiJ	ENSTCUG00005034002	protein coding gene	Chr5:117319698-117329626 (+)
CBA/J	ENSMUSG00210010041	protein coding gene	Chr5:118790215-118800025 (+)
DBA/2J	ENSMUSG00185006794	protein coding gene	Chr5:121841283-121851095 (+)
FVB/NJ	ENSMUSG00205044293	protein coding gene	Chr5:117715805-117725616 (+)
JF1/MsJ	ENSUMUG00000048092	protein coding gene	Chr5:124700880-124710726 (+)
LP/J	ENSMUSG00230039701	protein coding gene	Chr5:125922889-125932699 (+)
NOD/ShiLtJ	ENSMUSG00190040892	protein coding gene	Chr5:117715632-117725444 (+)
NZO/HlLtJ	ENSMUSG00225013652	protein coding gene	Chr5:133620669-133630480 (+)
PWK/PhJ	ENSLUMG00010041130	protein coding gene	Chr5:116602498-116612367 (+)
SPRET/EiJ	ENSMSPG00010036751	protein coding gene	Chr5:119895336-119905233 (+)
WSB/EiJ	ENSIUOG00005014469	protein coding gene	Chr5:120414207-120424006 (+)

Human Ortholog

TMED2, transmembrane p24 trafficking protein 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TMED2, transmembrane p24 trafficking protein 2
Synonyms

p24, P24A, p24b1, p24beta1, RNP24
Links

HGNC:16996

NCBI Gene ID: 10959

UniProt: Q15363
Chr Location

12q24.31; chr12:123584526-123598582 (+) GRCh38

MGI Vertebrate Homology

Tmed2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TMED2
Gene Tree

Tmed2

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Phenotype Summary

19 phenotypes from 3 alleles in 3 genetic backgrounds
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (ENU)

1
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

8
Radiation induced

1
Genomic Mutations

2 involving Tmed2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

9 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for an ENU-induced allele exhibit embryonic lethality, embryonic growth retardation, caudal body truncation, and abnormal heart development.

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All GO Annotations

85
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

714
Tissues

75
cDNA Data

14
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tmed2

ZFIN tmed2

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All Sequences

70
RefSeq

6
UniProt

9
CCDS

CCDS19679.1

Ensembl

ENSMUSG00000029390 (Evidence)
NCBI Gene

56334

			Length	Strain/Species	Flank
genomic	56334	NCBI Gene Model \| MGI Sequence Detail	9732	C57BL/6J	± kb
transcript	NM_001403253	RefSeq \| MGI Sequence Detail	2015	C57BL/6
polypeptide	Q9R0Q3	UniProt \| EBI \| MGI Sequence Detail	201	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000016403 transmembrane emp24 domain-containing protein 2

(term hierarchy)
InterPro Domains

IPR009038 GOLD domain

IPR036598 GOLD domain superfamily

IPR015720 Transmembrane emp24 domain-containing protein
GlyGen

Q9R0Q3 1 site, 1 O-linked glycan (1 site)

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All nucleic 20

cDNA 14

Primer pair 5

Other 1

Antibodies 1

Microarray probesets 9

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MGI:1916364, MGI:1923572

Summaries

All 48

Developmental Gene Expression 6

Gene Ontology 12

Phenotypes 16
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:335878 Montanes-Agudo P, et al., The RNA-binding protein QKI governs a muscle-specific alternative splicing program that shapes the contractile function of cardiomyocytes. Cardiovasc Res. 2023 May 22;119(5):1161-1174

TSS for Tmed2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr48903	Chr5:124678806-124678849 (+)	-7 bp
Tssr48904	Chr5:124679359-124679378 (+)	534 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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