Ivd MGI Mouse Gene Detail - MGI:1929242 - isovaleryl coenzyme A dehydrogenase

Symbol

Ivd
Name

isovaleryl coenzyme A dehydrogenase
Synonyms

1300016K07Rik, 6720455E18Rik

Feature Type

protein coding gene
IDs

MGI:1929242
NCBI Gene: 56357
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr2:118692475-118713388 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 59.64 cM, cytoband E4-E5
Mapping Data

3 experiments

SNPs within 2kb

178 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1929242	protein coding gene	Chr2:118692435-118713390 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026325	protein coding gene	Chr2:121571298-121590443 (+)
A/J	MGP_AJ_G0026286	protein coding gene	Chr2:116632282-116652202 (+)
AKR/J	MGP_AKRJ_G0026265	protein coding gene	Chr2:119898112-119921458 (+)
BALB/cJ	MGP_BALBcJ_G0026299	protein coding gene	Chr2:116896389-116915701 (+)
C3H/HeJ	MGP_C3HHeJ_G0026045	protein coding gene	Chr2:120366761-120386017 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026746	protein coding gene	Chr2:125577944-125599768 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024126	protein coding gene	Chr2:111679279-111703093 (+)
CAST/EiJ	MGP_CASTEiJ_G0025507	protein coding gene	Chr2:120672696-120692871 (+)
CBA/J	MGP_CBAJ_G0026021	protein coding gene	Chr2:130001800-130025651 (+)
DBA/2J	MGP_DBA2J_G0026160	protein coding gene	Chr2:116059859-116080943 (+)
FVB/NJ	MGP_FVBNJ_G0026122	protein coding gene	Chr2:114882658-114902466 (+)
LP/J	MGP_LPJ_G0026261	protein coding gene	Chr2:121895241-121918036 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026141	protein coding gene	Chr2:134367463-134391318 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026801	protein coding gene	Chr2:120025257-120045009 (+)
PWK/PhJ	MGP_PWKPhJ_G0025243	protein coding gene	Chr2:115611135-115633336 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025042	protein coding gene	Chr2:119201768-119225484 (+)
WSB/EiJ	MGP_WSBEiJ_G0025576	protein coding gene	Chr2:120848422-120870895 (+)

Human Ortholog

IVD, isovaleryl-CoA dehydrogenase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IVD, isovaleryl-CoA dehydrogenase
Synonyms

ACAD2, IVDH
Links

HGNC:6186

NCBI Gene ID: 3712

neXtProt AC: NX_P26440

UniProt: P26440
Chr Location

15q15.1; chr15:40405485-40435947 (+) GRCh38

MGI Vertebrate Homology

Ivd stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: IVD
Gene Tree

Ivd

Diseases

2 with human IVD associations

				Human Disease	Mouse Models
				amino acid metabolic disorder IDs amino acid metabolic disorder DOID:9252 ICD10CM:E72.9 ICD9CM:270 ICD9CM:270.9 MESH:D000592 NCI:C97090 UMLS_CUI:C0002514
				isovaleric acidemia IDs isovaleric acidemia DOID:14753 ICD10CM:E71.110 MESH:C538167 NCI:C98964 OMIM:243500 UMLS_CUI:C0268575

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Gene trapped

1
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Ivd
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

25 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

25
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

832
Tissues

111
cDNA Data

6
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ivd

ZFIN ivd

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All Sequences

45
RefSeq

6
UniProt

1
CCDS

CCDS16586.1

Ensembl

ENSMUSG00000027332 (Evidence)
NCBI Gene

56357

			Length	Strain/Species	Flank
genomic	56357	NCBI Gene Model \| MGI Sequence Detail	20914	C57BL/6J	± kb
transcript	NM_019826	RefSeq \| MGI Sequence Detail	3623	C57BL/6
polypeptide	Q9JHI5	UniProt \| EBI \| MGI Sequence Detail	424	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000009166 isovaleryl-CoA dehydrogenase, mitochondrial

(term hierarchy)
EC

1.3.8.1, 1.3.8.4
InterPro Domains

IPR006089 Acyl-CoA dehydrogenase, conserved site

IPR036250 Acyl-CoA dehydrogenase-like, C-terminal

IPR009075 Acyl-CoA dehydrogenase/oxidase, C-terminal

IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal

IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily

IPR037069 Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily

IPR006091 Acyl-CoA oxidase/dehydrogenase, middle domain

IPR046373 Acyl-CoA oxidase/dehydrogenase, middle domain superfamily

IPR034183 Isovaleryl-CoA dehydrogenase

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All nucleic 11

Genomic 1

cDNA 9

Primer pair 1

Microarray probesets 3

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MGI:1914156, MGI:1925136, MGI:2138971

Summaries

All 45

Developmental Gene Expression 5

Gene Ontology 11

Phenotypes 10
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:338257 Peng MZ, et al., Mitochondrial FAD shortage in SLC25A32 deficiency affects folate-mediated one-carbon metabolism. Cell Mol Life Sci. 2022 Jun 21;79(7):375

TSS for Ivd:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr19584	Chr2:118692467-118692489 (+)	3 bp
Tssr19585	Chr2:118692490-118692503 (+)	22 bp
Tssr19586	Chr2:118700856-118700883 (+)	8,395 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23