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Sec1 Gene Detail
Summary
  • Symbol
    Sec1
  • Name
    secretory blood group 1
  • Synonyms
    Fut3, GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase FUT-III
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928893
    NCBI Gene: 56546
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:45327110-45343825 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 29.43 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    181 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1928893
protein coding gene Chr7:45327110-45343826 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032238
protein coding gene Chr7:45982024-45998772 (-)
A/J MGP_AJ_G0032217
protein coding gene Chr7:45073052-45090383 (-)
AKR/J MGP_AKRJ_G0032153
protein coding gene Chr7:46320737-46337450 (-)
BALB/cJ MGP_BALBcJ_G0032229
protein coding gene Chr7:45066981-45083790 (-)
C3H/HeJ MGP_C3HHeJ_G0031944
protein coding gene Chr7:46818075-46835307 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032721
protein coding gene Chr7:48234233-48250946 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029735
protein coding gene Chr7:47628439-47645250 (-)
CAST/EiJ MGP_CASTEiJ_G0031273
protein coding gene Chr7:38256443-38273181 (-)
CBA/J MGP_CBAJ_G0031909
protein coding gene Chr7:49840302-49857015 (-)
DBA/2J MGP_DBA2J_G0032067
protein coding gene Chr7:44751195-44767943 (-)
FVB/NJ MGP_FVBNJ_G0032018
protein coding gene Chr7:44524703-44542936 (-)
LP/J MGP_LPJ_G0032145
protein coding gene Chr7:46688813-46705510 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032055
protein coding gene Chr7:48524688-48541401 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032737
protein coding gene Chr7:45535810-45552619 (-)
PWK/PhJ MGP_PWKPhJ_G0030995
protein coding gene Chr7:38119538-38136360 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030833
protein coding gene Chr7:33558930-33578349 (-)
WSB/EiJ MGP_WSBEiJ_G0031390
protein coding gene Chr7:46040945-46057663 (-)



Homology
more
  • Human Ortholog
    FUT2, fucosyltransferase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FUT2, fucosyltransferase 2
  • Synonyms
    B12QTL1, SE, Se2, SEC2, sej
  • Links
    NCBI Gene ID: 2524
    neXtProt AC: NX_Q10981
    UniProt: Q10981

  • Chr Location
    19q13.33; chr19:48695971-48705951 (+)  GRCh38

  • Human Ortholog
    SEC1P, secretory blood group 1, pseudogene
  • Synonyms
    SEC1
  • Links
    NCBI Gene ID: 653677

  • Chr Location
    19q13.33; chr19:48638039-48682245 (+)  GRCh38

Human Diseases
more
  • Diseases
    1 with human FUT2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit decreased susceptibility to bacterial infection induced morbidity/mortality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56546 NCBI Gene Model | MGI Sequence Detail 16716 C57BL/6J ±  kb
    transcript NM_001405895 RefSeq | MGI Sequence Detail 2520 ZRU/MplStud  
    polypeptide P97353 UniProt | EBI | MGI Sequence Detail 368 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 8
      Primer pair 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 11
    • Earliest
      J:66377 Lin B, et al., GDP-fucose: beta-galactoside alpha1,2-fucosyltransferase, MFUT-II, and not MFUT-I or -III, is induced in a restricted region of the digestive tract of germ-free mice by host-microbe interactions and cycloheximide. Biochim Biophys Acta. 2000 Sep 27;1487(2-3):275-85
    • Latest
      J:335011 Ren Z, et al., Expression Analysis and the Roles of the Sec1 Gene in Regulating the Composition of Mouse Gut Microbiota. Genes (Basel). 2022 Oct 14;13(10)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    09/26/2023
    MGI 6.22
    The Jackson Laboratory