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Tdo2 Gene Detail
Summary
  • Symbol
    Tdo2
  • Name
    tryptophan 2,3-dioxygenase
  • Synonyms
    chky, TDO, TO
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928486
    NCBI Gene: 56720
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:81865719-81883035 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 35.97 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    644 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1928486
 protein coding gene Chr3:81864397-81883509 (-)
129S1/SvImJ ENSMUSG00200018769
 protein coding gene Chr3:78717453-78736581 (-)
A/J ENSMUSG00195011707
 protein coding gene Chr3:78725353-78744461 (-)
AKR/J ENSMUSG00220001391
 protein coding gene Chr3:78681526-78700618 (-)
BALB/cJ ENSMUSG00180001888
 protein coding gene Chr3:78854400-78873489 (-)
C3H/HeJ ENSMUSG00175006956
 protein coding gene Chr3:78652022-78671133 (-)
C57BL/6NJ ENSMUSG00215001958
 protein coding gene Chr3:79104359-79123472 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025095
 protein coding gene Chr3:74810712-74828815 (-)
CAST/EiJ ENSTCUG00005001620
 protein coding gene Chr3:78191622-78210763 (-)
CBA/J ENSMUSG00210025598
 protein coding gene Chr3:78782555-78801663 (-)
DBA/2J ENSMUSG00185012533
 protein coding gene Chr3:78939082-78958168 (-)
FVB/NJ ENSMUSG00205006030
 protein coding gene Chr3:77709308-77728424 (-)
JF1/MsJ ENSUMUG00000001056
 protein coding gene Chr3:78460575-78479655 (-)
LP/J ENSMUSG00230009224
 protein coding gene Chr3:80926055-80945182 (-)
NOD/ShiLtJ ENSMUSG00190002616
 protein coding gene Chr3:79177565-79196680 (-)
NZO/HlLtJ ENSMUSG00225005116
 protein coding gene Chr3:83657024-83676138 (-)
PWK/PhJ ENSLUMG00010006163
 protein coding gene Chr3:78530040-78549139 (-)
SPRET/EiJ ENSMSPG00010016615
 protein coding gene Chr3:79331680-79352523 (-)
WSB/EiJ ENSIUOG00005002980
 protein coding gene Chr3:79150349-79169455 (-)



Homology
more
  • Human Ortholog
    TDO2, tryptophan 2,3-dioxygenase
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TDO2, tryptophan 2,3-dioxygenase
  • Synonyms
    HYPTRP, TDO, TO, TPH2, TRPO
  • Links
    NCBI Gene ID: 6999
    UniProt: P48775

  • Chr Location
    4q32.1; chr4:155854738-155920414 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human TDO2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    3 images
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased plasma and brain levels of tryptophan, increased serotonin levels in the brain, decreased anxiety-related behavior, increased neuronal precursor proliferation and accelerated neurogenesis in the granule cell layer of the olfactory bulb.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    50
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    754
  • Tissues
    111
  • cDNA Data
    99
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56720 NCBI Gene Model | MGI Sequence Detail 17317 C57BL/6J ±  kb
    transcript NM_019911 RefSeq | MGI Sequence Detail 1646 FVB/N  
    polypeptide P48776 UniProt | EBI | MGI Sequence Detail 406 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 104
      cDNA 100
      Primer pair 3
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2139552, MGI:3617202
    References
    more
    • Summaries
      All 78
      Developmental Gene Expression 11
      Diseases 1
      Gene Ontology 15
      Phenotypes 26
    • Earliest
      J:54660 Kamiya A, et al., Fetal liver development requires a paracrine action of oncostatin M through the gp130 signal transducer. EMBO J. 1999 Apr 15;18(8):2127-36
    • Latest
      J:390093 Bowman CE, et al., Off-target depletion of plasma tryptophan by allosteric inhibitors of BCKDK. Mol Metab. 2025 Jul;97:102165
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory