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Cnpy2 Gene Detail
Summary
  • Symbol
    Cnpy2
  • Name
    canopy FGF signaling regulator 2
  • Synonyms
    5330432A10Rik, D10Bwg1546e, Tmem4, Zsig9
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928477
    NCBI Gene: 56530
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:128157972-128163056 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 76.52 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    72 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1928477
 protein coding gene Chr10:128157972-128163422 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017859
 protein coding gene Chr10:132043710-132048197 (+)
A/J MGP_AJ_G0017834
 protein coding gene Chr10:126747353-126751877 (+)
AKR/J MGP_AKRJ_G0017797
 protein coding gene Chr10:130472680-130477289 (+)
BALB/cJ MGP_BALBcJ_G0017798
 protein coding gene Chr10:127131768-127136494 (+)
C3H/HeJ MGP_C3HHeJ_G0017621
 protein coding gene Chr10:130635949-130640475 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018253
 protein coding gene Chr10:136525542-136531667 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015931
 protein coding gene Chr10:120682712-120687028 (+)
CAST/EiJ MGP_CASTEiJ_G0017182
 protein coding gene Chr10:131339943-131344311 (+)
CBA/J MGP_CBAJ_G0017591
 protein coding gene Chr10:142068010-142074419 (+)
DBA/2J MGP_DBA2J_G0017697
 protein coding gene Chr10:125808605-125813111 (+)
FVB/NJ MGP_FVBNJ_G0017692
 protein coding gene Chr10:124737241-124742039 (+)
LP/J MGP_LPJ_G0017771
 protein coding gene Chr10:132642166-132647414 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017720
 protein coding gene Chr10:144652914-144657642 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018293
 protein coding gene Chr10:130566928-130572639 (+)
PWK/PhJ MGP_PWKPhJ_G0016967
 protein coding gene Chr10:126068764-126073689 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016756
 protein coding gene Chr10:129659052-129665846 (+)
WSB/EiJ MGP_WSBEiJ_G0017241
 protein coding gene Chr10:130782775-130788460 (+)



Homology
more
  • Human Ortholog
    CNPY2, canopy FGF signaling regulator 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CNPY2, canopy FGF signaling regulator 2
  • Synonyms
    HP10390, MSAP, TMEM4, ZSIG9
  • Links
    NCBI Gene ID: 10330
    neXtProt AC: NX_Q9Y2B0
    UniProt: Q9Y2B0

  • Chr Location
    12q13.3; chr12:56309842-56316346 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased susceptibility to diet-induced obesity and are protected from high fat diet-induced and endoplasmic reticulum stress-induced liver damage and steatosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    2
  • cDNA Data
    10
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56530 NCBI Gene Model | MGI Sequence Detail 5085 C57BL/6J ±  kb
    transcript NM_019953 RefSeq | MGI Sequence Detail 1017 Not Specified  
    polypeptide Q9QXT0 UniProt | EBI | MGI Sequence Detail 182 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 12
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-35737, MGI:107272, MGI:1915313, MGI:2143830
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 2
      Gene Ontology 3
      Phenotypes 10
    • Earliest
      J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
    • Latest
      J:277868 Hong F, et al., CNPY2 is a key initiator of the PERK-CHOP pathway of the unfolded protein response. Nat Struct Mol Biol. 2017 Oct;24(10):834-839
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory