Mrps25 MGI Mouse Gene Detail - MGI:1928140 - mitochondrial ribosomal protein S25

Symbol

Mrps25
Name

mitochondrial ribosomal protein S25
Synonyms

2810429N01Rik, Rpms25

Feature Type

protein coding gene
IDs

MGI:1928140
NCBI Gene: 64658
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr6:92146506-92161014 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 41.03 cM, cytoband D3
Mapping Data

2 experiments

SNPs within 2kb

79 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1928140	protein coding gene	Chr6:92146493-92161014 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0031056	protein coding gene	Chr6:93805531-93816551 (-)
A/J	MGP_AJ_G0031025	protein coding gene	Chr6:90234396-90248708 (-)
AKR/J	MGP_AKRJ_G0030956	protein coding gene	Chr6:92727246-92742600 (-)
BALB/cJ	MGP_BALBcJ_G0031036	protein coding gene	Chr6:90194313-90209548 (-)
C3H/HeJ	MGP_C3HHeJ_G0030672	protein coding gene	Chr6:91688102-91704049 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0031495	protein coding gene	Chr6:96221665-96231516 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028662	protein coding gene	Chr6:88207541-88225503 (-)
CAST/EiJ	MGP_CASTEiJ_G0030143	protein coding gene	Chr6:92860955-92873877 (-)
CBA/J	MGP_CBAJ_G0030722	protein coding gene	Chr6:99800087-99811308 (-)
DBA/2J	MGP_DBA2J_G0030875	protein coding gene	Chr6:89408584-89423471 (-)
FVB/NJ	MGP_FVBNJ_G0030829	protein coding gene	Chr6:88626501-88639613 (-)
LP/J	MGP_LPJ_G0030955	protein coding gene	Chr6:93754925-93767872 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030863	protein coding gene	Chr6:103836693-103852004 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031522	protein coding gene	Chr6:92581871-92594965 (-)
PWK/PhJ	no annotation
SPRET/EiJ	MGP_SPRETEiJ_G0029688	protein coding gene	Chr6:91496768-91506027 (-)
WSB/EiJ	MGP_WSBEiJ_G0030227	protein coding gene	Chr6:93050817-93064699 (-)

Human Ortholog

MRPS25, mitochondrial ribosomal protein S25

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MRPS25, mitochondrial ribosomal protein S25
Synonyms

COXPD50, MRP-S25, mS25, RPMS25
Links

HGNC:14511

NCBI Gene ID: 64432

neXtProt AC: NX_P82663

UniProt: P82663
Chr Location

3p25.1; chr3:15009611-15065339 (-) GRCh38

MGI Vertebrate Homology

Mrps25 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MRPS25
Gene Tree

Mrps25

Diseases

1 with human MRPS25 associations

				Human Disease	Mouse Models
				combined oxidative phosphorylation deficiency 50 IDs combined oxidative phosphorylation deficiency 50 DOID:0112111 OMIM:619025

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

13 phenotypes from 1 allele in 2 genetic backgrounds
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

2
Gene trapped

3
Spontaneous

1
Targeted

5
Genomic Mutations

1 involving Mrps25
Incidental Mutations

Mutagenetix
Find Mice (IMSR)

13 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit embryonic growth retardation, failure of primitive streak formation, disorganized extraembryonic tissue, and complete lethality prior to organogenesis.

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All GO Annotations

10
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

807
Tissues

76
cDNA Data

10
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA MRPS25

Xenbase mrps25

ZFIN mrps25

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All Sequences

41
RefSeq

2
UniProt

2
CCDS

CCDS20373.1

Ensembl

ENSMUSG00000014551 (Evidence)
NCBI Gene

64658

			Length	Strain/Species	Flank
genomic	ENSMUSG00000014551	Ensembl Gene Model \| MGI Sequence Detail	14509	C57BL/6J	± kb
transcript	ENSMUST00000140438	Ensembl \| MGI Sequence Detail	6073	Not Applicable
polypeptide	ENSMUSP00000114402	Ensembl \| MGI Sequence Detail	171	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000010633 small ribosomal subunit protein mS25

(term hierarchy)
PDB

7PNT, 7PNU, 7PNV, 7PNW
InterPro Domains

IPR007741 Ribosomal protein/NADH dehydrogenase domain

IPR040049 Ribosomal subunit protein mS25/mL61, mitochondrial

IPR036249 Thioredoxin-like superfamily

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All nucleic 12

cDNA 10

Primer pair 2

Microarray probesets 7

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MGI:1913713

Summaries

All 48

Developmental Gene Expression 7

Gene Ontology 9

Phenotypes 16
Earliest

J:65180 Redkar AA, et al., Genes in the first and fourth inversions of the mouse t complex synergistically mediate sperm capacitation and interactions with the oocyte. Dev Biol. 2000 Oct 15;226(2):267-80
Latest

J:317822 Chern T, et al., Mutations in Hcfc1 and Ronin result in an inborn error of cobalamin metabolism and ribosomopathy. Nat Commun. 2022 Jan 10;13(1):134

TSS for Mrps25:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr62105	Chr6:92160953-92161019 (-)	28 bp
Tssr62104	Chr6:92154433-92154437 (-)	6,579 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23