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Tspan5 Gene Detail
Summary
  • Symbol
    Tspan5
  • Name
    tetraspanin 5
  • Synonyms
    2810455A09Rik, 4930505M03Rik, NET-4, Tm4sf9
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928096
    NCBI Gene: 56224
  • Alliance
    genome feature page
  • Transcription Start Sites
    20 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:138447609-138610194 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 64.42 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4971 from dbSNP Build 142
  • Strain Annotations
    26
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1928096
 protein coding gene Chr3:138447609-138613666 (+)
129S1/SvImJ ENSMUSGG00200054737
 protein coding gene Chr3:135227237-135352466 (+)
129S1/SvImJ ENSMUSG00200002742
 protein coding gene Chr3:135374867-135394512 (+)
A/J ENSMUSGG00195054936
 protein coding gene Chr3:135337081-135462403 (+)
A/J ENSMUSG00195003930
 protein coding gene Chr3:135484744-135497664 (+)
AKR/J ENSMUSGG00220054681
 protein coding gene Chr3:133786136-133912733 (+)
AKR/J ENSMUSG00220003284
 protein coding gene Chr3:133935109-133948053 (+)
BALB/cJ ENSMUSGG00180055329
 protein coding gene Chr3:135251149-135376454 (+)
BALB/cJ ENSMUSG00180011370
 protein coding gene Chr3:135398795-135411715 (+)
C3H/HeJ ENSMUSGG00175054972
 protein coding gene Chr3:134854377-134979675 (+)
C3H/HeJ ENSMUSG00175017956
 protein coding gene Chr3:135002016-135014937 (+)
C57BL/6NJ ENSMUSG00215020408
 protein coding gene Chr3:135756315-135769252 (+)
C57BL/6NJ ENSMUSGG00215055575
 protein coding gene Chr3:135608066-135733976 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025685
 protein coding gene Chr3:132201599-132368180 (+)
CAST/EiJ no annotation
CBA/J ENSMUSG00210031273
 protein coding gene Chr3:135611989-135630991 (+)
CBA/J ENSMUSGG00210054600
 protein coding gene Chr3:135464299-135589588 (+)
DBA/2J ENSMUSGG00185057875
 protein coding gene Chr3:136080044-136205280 (+)
DBA/2J ENSMUSG00185003492
 protein coding gene Chr3:136227608-136240551 (+)
FVB/NJ ENSMUSG00205016662
 protein coding gene Chr3:134536696-134549635 (+)
FVB/NJ ENSMUSGG00205054262
 protein coding gene Chr3:134387707-134514320 (+)
JF1/MsJ no annotation
LP/J ENSMUSG00230002196
 protein coding gene Chr3:138188587-138208231 (+)
LP/J ENSMUSGG00230055602
 protein coding gene Chr3:138040968-138166188 (+)
NOD/ShiLtJ ENSMUSGG00190054799
 protein coding gene Chr3:136461257-136587844 (+)
NOD/ShiLtJ ENSMUSG00190004482
 protein coding gene Chr3:136610244-136629889 (+)
NZO/HlLtJ ENSMUSGG00225055448
 protein coding gene Chr3:140508901-140634121 (+)
NZO/HlLtJ ENSMUSG00225005125
 protein coding gene Chr3:140656520-140676164 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    TSPAN5, tetraspanin 5
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TSPAN5, tetraspanin 5
  • Synonyms
    NET-4, NET4, TM4SF9, TSPAN-5
  • Links
    NCBI Gene ID: 10098
    UniProt: P62079

  • Chr Location
    4q23; chr4:98470365-98658690 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    921
  • Tissues
    141
  • cDNA Data
    52
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 56224 NCBI Gene Model | MGI Sequence Detail 162586 C57BL/6J ±  kb
transcript NM_019571 RefSeq | MGI Sequence Detail 3100 C57BL/6  
polypeptide P62080 UniProt | EBI | MGI Sequence Detail 268 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 55
    cDNA 54
    Other 1

    Microarray probesets 7
Other
Accession IDs
less
MGI:1920043, MGI:1922322, MGI:2139900
References
more
  • Summaries
    All 55
    Developmental Gene Expression 4
    Diseases 1
    Gene Ontology 8
    Phenotypes 17
  • Earliest
    J:64920 Todd SC, et al., Sequences and expression of six new members of the tetraspanin/TM4SF family. Biochim Biophys Acta. 1998 Jul 30;1399(1):101-4
  • Latest
    J:361165 Colbert JD, et al., Tetraspanin-5-mediated MHC class I clustering is required for optimal CD8 T cell activation. Proc Natl Acad Sci U S A. 2022 Oct 18;119(42):e2122188119
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory