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Trps1 Gene Detail
Summary
  • Symbol
    Trps1
  • Name
    transcriptional repressor GATA binding 1
  • Synonyms
    D15Ertd586e, trichorhinophalangeal syndrome I (human)
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927616
    NCBI Gene: 83925
  • Alliance
    genome feature page
  • Transcription Start Sites
    52 TSS
  • Regulated by
    Rr695529 (1 regulatory region)
Location &
Maps
more
  • Sequence Map
    Chr15:50518148-50753859 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 19.18 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5943 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1927616
 protein coding gene Chr15:50518148-50754027 (-)
129S1/SvImJ ENSMUSGG00200054842
 protein coding gene Chr15:47689170-47689936 (-)
A/J ENSMUSGG00195055290
 protein coding gene Chr15:47687260-47688026 (-)
AKR/J ENSMUSGG00220054702
 protein coding gene Chr15:47682397-47683163 (-)
BALB/cJ ENSMUSGG00180055424
 protein coding gene Chr15:47664993-47665759 (-)
C3H/HeJ ENSMUSGG00175054740
 protein coding gene Chr15:47878360-47879126 (-)
C57BL/6NJ ENSMUSG00215003184
 protein coding gene Chr15:47631899-47639921 (-)
C57BL/6NJ ENSMUSGG00215055618
 protein coding gene Chr15:47658575-47659341 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019779
 protein coding gene Chr15:44665064-44903104 (-)
CAST/EiJ no annotation
CBA/J ENSMUSGG00210055047
 protein coding gene Chr15:47759452-47760218 (-)
DBA/2J ENSMUSGG00185057623
 protein coding gene Chr15:47731229-47731995 (-)
FVB/NJ ENSMUSGG00205054419
 protein coding gene Chr15:47559437-47560203 (-)
FVB/NJ ENSMUSG00205012672
 protein coding gene Chr15:47532764-47540786 (-)
JF1/MsJ no annotation
LP/J ENSMUSGG00230055716
 protein coding gene Chr15:51049975-51050741 (-)
NOD/ShiLtJ ENSMUSGG00190054966
 protein coding gene Chr15:47721751-47722517 (-)
NOD/ShiLtJ ENSMUSG00190008373
 protein coding gene Chr15:47695076-47703100 (-)
NZO/HlLtJ ENSMUSGG00225055673
 protein coding gene Chr15:51378495-51379261 (-)
NZO/HlLtJ ENSMUSG00225028515
 protein coding gene Chr15:51351816-51359838 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    TRPS1, transcriptional repressor GATA binding 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRPS1, transcriptional repressor GATA binding 1
  • Synonyms
    GC79, LGCR
  • Links
    NCBI Gene ID: 7227
    UniProt: Q9UHF7

  • Chr Location
    8q23.3; chr8:115408496-115809673 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Trps1 mouse models; 3 with human TRPS1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    77 phenotypes from 6 alleles in 7 genetic backgrounds
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit absent vibrissae, craniofacial anomalies, cleft palate, thoracic spine and rib defects, and neonatal lethality due to respiratory failure. Mice homozygous for a reporter allele show additional defects in chondrocyte proliferation and apoptosis as well as reduced nephron formation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1408
  • Tissues
    300
  • cDNA Data
    125
  • Literature Summary
    38
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038679 Ensembl Gene Model | MGI Sequence Detail 235712 C57BL/6J ±  kb
    transcript ENSMUST00000183757 Ensembl | MGI Sequence Detail 6202 Not Applicable  
    polypeptide ENSMUSP00000139017 Ensembl | MGI Sequence Detail 1285 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      14 Sequences
    • Protein Ontology
      PR:000016704 zinc finger transcription factor Trps1
      (term hierarchy)
    • InterPro Domains
      IPR028440 Transcription factor TRPS1
      IPR036236 Zinc finger C2H2 superfamily
      IPR013087 Zinc finger C2H2-type
      IPR000679 Zinc finger, GATA-type
      IPR013088 Zinc finger, NHR/GATA-type
      IPR060334 Zinc finger transcription factor Trps1, fifth C2H2 zinc finger
      IPR060309 Zinc finger transcription factor Trps1, first C2H2 zinc finger
      IPR060318 Zinc finger transcription factor Trps1, fourth C2H2 zinc finger
      IPR060317 Zinc finger transcription factor Trps1, second C2H2 zinc finger
      IPR060307 Zinc finger transcription factor Trps1, third C2H2 zinc finger
    • GlyGen
      Q925H1 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 134
      cDNA 127
      Primer pair 7
      Antibodies 5

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1261920, MGI:2145946, MGI:2146008
    References
    more
    • Summaries
      All 111
      Developmental Gene Expression 38
      Diseases 1
      Gene Ontology 11
      Phenotypes 41
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:390120 Trowe MO, et al., Mesenchymal WNT signaling coordinates epithelial and mesenchymal differentiation in the developing murine ureter. Cell Commun Signal. 2026 Jul 21;24(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory