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Foxb1 Gene Detail
Summary
  • Symbol
    Foxb1
  • Name
    forkhead box B1
  • Synonyms
    C43, Fkh5, Foxb1a, Foxb1b, Hfh-e5.1, Mf3, TWH
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927549
    NCBI Gene: 64290
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:69664992-69668222 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 38.76 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    122 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1927549
 protein coding gene Chr9:69664992-69668222 (-)
129S1/SvImJ ENSMUSG00200040860
 protein coding gene Chr9:66753469-66756694 (-)
A/J ENSMUSG00195024712
 protein coding gene Chr9:66537875-66541096 (-)
AKR/J ENSMUSG00220040326
 protein coding gene Chr9:66676717-66679947 (-)
BALB/cJ ENSMUSG00180015383
 protein coding gene Chr9:66652247-66655467 (-)
C3H/HeJ ENSMUSG00175011003
 protein coding gene Chr9:66665658-66668878 (-)
C57BL/6NJ ENSMUSG00215026035
 protein coding gene Chr9:66608548-66611778 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032396
 protein coding gene Chr9:66933531-66936739 (-)
CAST/EiJ ENSTCUG00005026341
 protein coding gene Chr9:66476358-66479561 (-)
CBA/J ENSMUSG00210014304
 protein coding gene Chr9:66746405-66749625 (-)
DBA/2J ENSMUSG00185029239
 protein coding gene Chr9:66770121-66773340 (-)
FVB/NJ ENSMUSG00205022474
 protein coding gene Chr9:67044317-67047538 (-)
JF1/MsJ ENSUMUG00000026402
 protein coding gene Chr9:66798602-66801835 (-)
LP/J ENSMUSG00230024239
 protein coding gene Chr9:66948630-66951855 (-)
NOD/ShiLtJ ENSMUSG00190018787
 protein coding gene Chr9:66873659-66876902 (-)
NZO/HlLtJ ENSMUSG00225044756
 protein coding gene Chr9:67076800-67080023 (-)
PWK/PhJ ENSLUMG00010024641
 protein coding gene Chr9:66749320-66752548 (-)
SPRET/EiJ ENSMSPG00010018009
 protein coding gene Chr9:67838185-67841399 (-)
WSB/EiJ ENSIUOG00005026283
 protein coding gene Chr9:66225367-66228630 (-)



Homology
more
  • Human Ortholog
    FOXB1, forkhead box B1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FOXB1, forkhead box B1
  • Synonyms
    FKH5, HFKH-5
  • Links
    NCBI Gene ID: 27023
    UniProt: Q99853

  • Chr Location
    15q22.2; chr15:60004234-60061730 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    34 phenotypes from 5 alleles in 8 genetic backgrounds
    2 phenotypes from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Targeted null mutant mice show variable embryonic lethality with neural tube defects or severe posterior reduction. Survivors have high postnatal mortality, reduced growth, motor weakness, midbrain abnormalities and females have a lactational defect.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1186
  • Tissues
    343
  • cDNA Data
    14
  • Literature Summary
    39
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 64290 NCBI Gene Model | MGI Sequence Detail 3231 C57BL/6J ±  kb
    transcript NM_022378 RefSeq | MGI Sequence Detail 2984 Not Specified  
    polypeptide Q64732 UniProt | EBI | MGI Sequence Detail 325 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      Genomic 5
      cDNA 16
      Primer pair 3
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-24019, MGD-MRK-39569, MGD-MRK-9817, MGI:103153, MGI:109570, MGI:1347486, MGI:95548
    References
    more
    • Summaries
      All 83
      Developmental Gene Expression 39
      Gene Ontology 12
      Phenotypes 22
    • Earliest
      J:11921 Sasaki H, et al., Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo. Development. 1993 May;118(1):47-59
    • Latest
      J:378516 Manning E, et al., Resolving forebrain developmental organisation by analysis of differential growth patterns. Nat Commun. 2025 Dec 21;17(1):901
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory