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Wtap Gene Detail
Summary
  • Symbol
    Wtap
  • Name
    WT1 associating protein
  • Synonyms
    2810408K05Rik, 9430038B09Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926395
    NCBI Gene: 60532
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:13185686-13211430 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 17, 8.73 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    561 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926395
protein coding gene Chr17:13185683-13213056 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023157
protein coding gene Chr17:10657812-10699257 (-)
A/J MGP_AJ_G0023125
protein coding gene Chr17:10473894-10505902 (-)
AKR/J MGP_AKRJ_G0023089
protein coding gene Chr17:10316956-10370374 (-)
BALB/cJ MGP_BALBcJ_G0023125
protein coding gene Chr17:10259330-10287427 (-)
C3H/HeJ MGP_C3HHeJ_G0022887
protein coding gene Chr17:10562981-10589426 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023567
protein coding gene Chr17:11050765-11077736 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021040
protein coding gene Chr17:3960025-3984793 (+)
CAST/EiJ MGP_CASTEiJ_G0022401
protein coding gene Chr17:10650582-10684140 (-)
CBA/J MGP_CBAJ_G0022860
protein coding gene Chr17:11481243-11506600 (-)
DBA/2J MGP_DBA2J_G0022992
protein coding gene Chr17:10112468-10143555 (-)
FVB/NJ MGP_FVBNJ_G0022963
protein coding gene Chr17:10046490-10073352 (-)
LP/J MGP_LPJ_G0023064
protein coding gene Chr17:10507280-10538729 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022982
protein coding gene Chr17:11109165-11134039 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023594
protein coding gene Chr17:10588194-10618420 (-)
PWK/PhJ MGP_PWKPhJ_G0022148
protein coding gene Chr17:9809192-9838017 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021980
protein coding gene Chr17:10012144-10040963 (-)
WSB/EiJ MGP_WSBEiJ_G0022459
protein coding gene Chr17:10906884-10934693 (-)



Homology
more
  • Human Ortholog
    WTAP, WT1 associated protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WTAP, WT1 associated protein
  • Synonyms
    Mum2
  • Links
    NCBI Gene ID: 9589
    neXtProt AC: NX_Q15007
    UniProt: Q15007

  • Chr Location
    6q25.3; chr6:159725585-159756319 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a mutation display lethality during embryogenesis with abnormalities appearing during gastrulation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 60532 NCBI Gene Model | MGI Sequence Detail 25745 C57BL/6J ±  kb
    transcript NM_175394 RefSeq | MGI Sequence Detail 4967 C57BL/6  
    polypeptide Q9ER69 UniProt | EBI | MGI Sequence Detail 396 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000017460 pre-mRNA-splicing regulator WTAP
    • InterPro Domains
      IPR033757 Pre-mRNA-splicing regulator WTAP
    • GlyGen
      Q9ER69 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 14
      Primer pair 3

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1922064, MGI:1924525
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 8
      Gene Ontology 10
      Phenotypes 26
    • Earliest
      J:6493 Sakano H, et al., Identification and nucleotide sequence of a diversity DNA segment (D) of immunoglobulin heavy-chain genes. Nature. 1981 Apr 16;290(5807):562-5
    • Latest
      J:350116 Shi L, et al., Downregulation of Wtap causes dilated cardiomyopathy and heart failure. J Mol Cell Cardiol. 2024 Jan 14;188:38-51

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    10/01/2024
    MGI 6.24
    The Jackson Laboratory