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Pgap6 Gene Detail
Summary
  • Symbol
    Pgap6
  • Name
    post-glycosylphosphatidylinositol attachment to proteins 6
  • Synonyms
    M83, Rxylt1, Tmem8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926283
    NCBI Gene: 60455
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:26332290-26342228 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 13.06 cM, cytoband B1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    294 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926283
 protein coding gene Chr17:26332273-26342228 (+)
129S1/SvImJ ENSMUSG00200052741
 protein coding gene Chr17:21777760-21787712 (+)
A/J ENSMUSG00195054265
 protein coding gene Chr17:22804912-22814865 (+)
AKR/J ENSMUSG00220053126
 protein coding gene Chr17:21841721-21851674 (+)
BALB/cJ ENSMUSG00180040231
 protein coding gene Chr17:22075798-22085751 (+)
C3H/HeJ ENSMUSG00175052299
 protein coding gene Chr17:21834018-21843972 (+)
C57BL/6NJ ENSMUSG00215051462
 protein coding gene Chr17:21841885-21851842 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021272
 protein coding gene Chr17:21960223-21970058 (+)
CAST/EiJ ENSTCUG00005039705
 protein coding gene Chr17:22433958-22443714 (+)
CBA/J ENSMUSG00210049709
 protein coding gene Chr17:21672851-21682808 (+)
DBA/2J ENSMUSG00185052775
 protein coding gene Chr17:23893148-23903101 (+)
FVB/NJ ENSMUSG00205045961
 protein coding gene Chr17:22148861-22158814 (+)
JF1/MsJ ENSUMUG00000053746
 protein coding gene Chr17:23338109-23347849 (+)
LP/J ENSMUSG00230054946
 protein coding gene Chr17:25282274-25292226 (+)
NOD/ShiLtJ ENSMUSG00190043485
 protein coding gene Chr17:21781870-21791823 (+)
NZO/HlLtJ ENSMUSG00225053037
 protein coding gene Chr17:27212211-27222164 (+)
PWK/PhJ ENSLUMG00010032373
 protein coding gene Chr17:21250673-21260406 (+)
SPRET/EiJ ENSMSPG00010048037
 protein coding gene Chr17:22576719-22586455 (+)
WSB/EiJ ENSIUOG00005050942
 protein coding gene Chr17:22514384-22524345 (+)



Homology
more
  • Human Ortholog
    PGAP6, post-GPI attachment to proteins 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PGAP6, post-GPI attachment to proteins 6
  • Synonyms
    GPI-PLA2, M83, TMEM6, TMEM8, TMEM8A
  • Links
    NCBI Gene ID: 58986
    UniProt: Q9HCN3

  • Chr Location
    16p13.3; chr16:370788-387113 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    2 images
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit defects in rostral-caudal axis patterning, embryonic growth arrest, and embryonic lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    681
  • Tissues
    13
  • cDNA Data
    62
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 60455 NCBI Gene Model | MGI Sequence Detail 9939 C57BL/6J ±  kb
    transcript NM_021793 RefSeq | MGI Sequence Detail 3480 C57BL/6  
    polypeptide Q9ESN3 UniProt | EBI | MGI Sequence Detail 769 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 63
      cDNA 63

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2147065, MGI:6192075, MGI:6194630, MGI:6390558
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 2
      Gene Ontology 9
      Phenotypes 16
    • Earliest
      J:64829 Motohashi T, et al., Molecular cloning and chromosomal mapping of a novel five-span transmembrane protein gene, M83. Biochem Biophys Res Commun. 2000 Sep 16;276(1):244-50
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory