Ube2j1 MGI Mouse Gene Detail - MGI:1926245 - ubiquitin-conjugating enzyme E2J 1

Symbol

Ube2j1
Name

ubiquitin-conjugating enzyme E2J 1
Synonyms

0710008M05Rik, 1110030I22Rik, Ncube, Ubc6p

Feature Type

protein coding gene
IDs

MGI:1926245
NCBI Gene: 56228
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr4:33031416-33052363 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 14.61 cM, cytoband A5
Mapping Data

3 experiments

SNPs within 2kb

208 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1926245	protein coding gene	Chr4:33031380-33052367 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028117	protein coding gene	Chr4:30524151-30545431 (+)
A/J	MGP_AJ_G0028075	protein coding gene	Chr4:29432798-29454131 (+)
AKR/J	MGP_AKRJ_G0028038	protein coding gene	Chr4:30201022-30221845 (+)
BALB/cJ	MGP_BALBcJ_G0028086	protein coding gene	Chr4:29695733-29717453 (+)
C3H/HeJ	MGP_C3HHeJ_G0027815	protein coding gene	Chr4:30488237-30509242 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028528	protein coding gene	Chr4:31720939-31742868 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025869	protein coding gene	Chr4:27498820-27519956 (+)
CAST/EiJ	MGP_CASTEiJ_G0027270	protein coding gene	Chr4:30265935-30287924 (+)
CBA/J	MGP_CBAJ_G0027787	protein coding gene	Chr4:32753940-32777523 (+)
DBA/2J	MGP_DBA2J_G0027931	protein coding gene	Chr4:29436374-29457229 (+)
FVB/NJ	MGP_FVBNJ_G0027897	protein coding gene	Chr4:28861951-28883846 (+)
LP/J	MGP_LPJ_G0028039	protein coding gene	Chr4:30615539-30637060 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027930	protein coding gene	Chr4:35318135-35339887 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028587	protein coding gene	Chr4:30210539-30232191 (+)
PWK/PhJ	MGP_PWKPhJ_G0026989	protein coding gene	Chr4:29436312-29457570 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026818	protein coding gene	Chr4:30098328-30119353 (+)
WSB/EiJ	MGP_WSBEiJ_G0027346	protein coding gene	Chr4:30208167-30228553 (+)

Human Ortholog

UBE2J1, ubiquitin conjugating enzyme E2 J1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

UBE2J1, ubiquitin conjugating enzyme E2 J1
Synonyms

CGI-76, HSPC153, HSPC205, HSU93243, NCUBE1, NCUBE-1, UBC6, UBC6E, Ubc6p
Links

HGNC:17598

NCBI Gene ID: 51465

neXtProt AC: NX_Q9Y385

UniProt: Q9Y385
Chr Location

6q15; chr6:89326625-89352722 (-) GRCh38

MGI Vertebrate Homology

Ube2j1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: UBE2J1
Gene Tree

Ube2j1

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Phenotype Summary

21 phenotypes from 2 alleles in 2 genetic backgrounds
3 images
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically and radiation induced

1
Gene trapped

1
Targeted

4
Genomic Mutations

1 involving Ube2j1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

21 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit partial postnatal lethality, decreased body size, and male infertility associated with defective spermiogenesis, teratozoospermia, and asthenozoospermia.

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All GO Annotations

20
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1106
Tissues

64
cDNA Data

95
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ube2j1

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All Sequences

56
RefSeq

4
UniProt

5
CCDS

CCDS18019.1

Ensembl

ENSMUSG00000028277 (Evidence)
NCBI Gene

56228

			Length	Strain/Species	Flank
genomic	ENSMUSG00000028277	Ensembl Gene Model \| MGI Sequence Detail	20948	C57BL/6J	± kb
transcript	ENSMUST00000124992	Ensembl \| MGI Sequence Detail	3530	Not Applicable
polypeptide	ENSMUSP00000118333	Ensembl \| MGI Sequence Detail	318	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000016978 ubiquitin-conjugating enzyme E2 J1

(term hierarchy)
EC

2.3.2.23
InterPro Domains

IPR000608 Ubiquitin-conjugating enzyme E2

IPR016135 Ubiquitin-conjugating enzyme/RWD-like

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All nucleic 95

cDNA 95

Microarray probesets 6

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MGI:1915675, MGI:1915927

Summaries

All 42

Developmental Gene Expression 2

Gene Ontology 9

Phenotypes 9
Earliest

J:64685 Lester D, et al., Identification of a family of noncanonical ubiquitin-conjugating enzymes structurally related to yeast UBC6. Biochem Biophys Res Commun. 2000 Mar 16;269(2):474-80
Latest

J:330415 Nozawa K, et al., The testis-specific E3 ubiquitin ligase RNF133 is required for fecundity in mice. BMC Biol. 2022 Jul 13;20(1):161

TSS for Ube2j1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr36732	Chr4:33031371-33031524 (+)	32 bp
Tssr36733	Chr4:33031527-33031556 (+)	126 bp
Tssr36734	Chr4:33031724-33031740 (+)	316 bp
Tssr36735	Chr4:33031748-33031765 (+)	341 bp
Tssr36736	Chr4:33045174-33045188 (+)	13,765 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23