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Cltrn Gene Detail
Summary
  • Symbol
    Cltrn
  • Name
    collectrin, amino acid transport regulator
  • Synonyms
    0610008J07Rik, collectrin, NX17, NX=17, Tmem27
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926234
    NCBI Gene: 57394
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:162873183-162901855 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 76.12 cM, cytoband F5
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    127 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926234
 protein coding gene ChrX:162871826-162901856 (+)
129S1/SvImJ MGP_129S1SvImJ_G0036251
 protein coding gene ChrX:162165217-162196237 (+)
A/J MGP_AJ_G0036221
 protein coding gene ChrX:161337394-161379104 (+)
AKR/J MGP_AKRJ_G0036149
 protein coding gene ChrX:166523390-166558718 (+)
BALB/cJ MGP_BALBcJ_G0036214
 protein coding gene ChrX:159338779-159374255 (+)
C3H/HeJ MGP_C3HHeJ_G0035921
 protein coding gene ChrX:162512564-162544793 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036737
 protein coding gene ChrX:166918510-166950193 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033557
 protein coding gene ChrX:152392880-152422989 (+)
CAST/EiJ MGP_CASTEiJ_G0035209
 protein coding gene ChrX:141494707-141525000 (+)
CBA/J MGP_CBAJ_G0035895
 protein coding gene ChrX:171748609-171783923 (+)
DBA/2J MGP_DBA2J_G0036061
 protein coding gene ChrX:160228905-160260084 (+)
FVB/NJ MGP_FVBNJ_G0035993
 protein coding gene ChrX:159360823-159390561 (+)
LP/J MGP_LPJ_G0036146
 protein coding gene ChrX:163301754-163332628 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0036025
 protein coding gene ChrX:180435183-180468729 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036776
 protein coding gene ChrX:161650178-161682057 (+)
PWK/PhJ MGP_PWKPhJ_G0034907
 protein coding gene ChrX:138274617-138305433 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034728
 protein coding gene ChrX:141990744-142020398 (+)
WSB/EiJ MGP_WSBEiJ_G0035344
 protein coding gene ChrX:159618920-159649868 (+)



Homology
more
  • Human Ortholog
    CLTRN, collectrin, amino acid transport regulator
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CLTRN, collectrin, amino acid transport regulator
  • Synonyms
    NX17, NX-17, TMEM27
  • Links
    NCBI Gene ID: 57393
    neXtProt AC: NX_Q9HBJ8
    UniProt: Q9HBJ8

  • Chr Location
    Xp22.2; chrX:15627318-15675644 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene result in defects in renal amino acid uptake.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    743
  • Tissues
    35
  • cDNA Data
    100
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 57394 NCBI Gene Model | MGI Sequence Detail 28673 C57BL/6J ±  kb
    transcript NM_020626 RefSeq | MGI Sequence Detail 1262 C57BL/6  
    polypeptide Q9ESG4 UniProt | EBI | MGI Sequence Detail 222 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 101
      cDNA 100
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1915565
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 10
      Gene Ontology 7
      Phenotypes 16
    • Earliest
      J:65057 Zhang H, et al., Screening for genes up-regulated in 5/6 nephrectomized mouse kidney. Kidney Int. 1999 Aug;56(2):549-58
    • Latest
      J:333889 Chu PL, et al., Collectrin (Tmem27) deficiency in proximal tubules causes hypertension in mice and a TMEM27 variant associates with blood pressure in males in a Latino cohort. Am J Physiol Renal Physiol. 2023 Jan 1;324(1):F30-F42
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory