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Dek Gene Detail
Summary
  • Symbol
    Dek
  • Name
    DEK proto-oncogene (DNA binding)
  • Synonyms
    1810019E15Rik, D13H6S231E
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926209
    NCBI Gene: 110052
  • Alliance
  • Transcription Start Sites
    18 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:47238251-47259677 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 24.50 cM, cytoband B1
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    123 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926209
protein coding gene Chr13:47238243-47261134 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020520
protein coding gene Chr13:45894054-45915471 (-)
A/J MGP_AJ_G0020474
protein coding gene Chr13:44292028-44313564 (-)
AKR/J MGP_AKRJ_G0020451
protein coding gene Chr13:45505778-45527204 (-)
BALB/cJ MGP_BALBcJ_G0020470
protein coding gene Chr13:44497826-44519243 (-)
C3H/HeJ MGP_C3HHeJ_G0020269
protein coding gene Chr13:45370123-45391539 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020903
protein coding gene Chr13:47277865-47299291 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018488
protein coding gene Chr13:42338203-42360026 (-)
CAST/EiJ MGP_CASTEiJ_G0019784
protein coding gene Chr13:45310932-45332273 (-)
CBA/J MGP_CBAJ_G0020230
protein coding gene Chr13:49239143-49260722 (-)
DBA/2J MGP_DBA2J_G0020352
protein coding gene Chr13:43844738-43866155 (-)
FVB/NJ MGP_FVBNJ_G0020331
protein coding gene Chr13:43362649-43384087 (-)
LP/J MGP_LPJ_G0020427
protein coding gene Chr13:46117723-46139140 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020360
protein coding gene Chr13:49058933-49082667 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020946
protein coding gene Chr13:45214892-45236329 (-)
PWK/PhJ MGP_PWKPhJ_G0019540
protein coding gene Chr13:43980546-44002355 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019368
protein coding gene Chr13:43882134-43904504 (-)
WSB/EiJ MGP_WSBEiJ_G0019846
protein coding gene Chr13:45518909-45540337 (-)



Homology
more
  • Human Ortholog
    DEK, DEK proto-oncogene
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DEK, DEK proto-oncogene
  • Synonyms
    D6S231E
  • Links
    NCBI Gene ID: 7913
    neXtProt AC: NX_P35659
    UniProt: P35659

  • Chr Location
    6p22.3; chr6:18224169-18264568 (-)  GRCh38.p7

  • Alliance of Genome Resources
    Dek stringent orthology
    1 human;1 mouse;1 rat;1 zebrafish
  • HCOP
    vertebrate homology predictions: DEK
  • Gene Tree
    Dek
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    6 phenotypes from multigenic genotypes
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit delayed development of DMBA- and TPA-induced papillomas.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021377 Ensembl Gene Model | MGI Sequence Detail 21427 C57BL/6J ±  kb
transcript ENSMUST00000021807 Ensembl | MGI Sequence Detail 2556 Not Applicable  
polypeptide ENSMUSP00000021807 Ensembl | MGI Sequence Detail 380 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 230
    cDNA 228
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-3410, MGI:1914254, MGI:89627
References
more
  • Summaries
    All 67
    Developmental Gene Expression 7
    Gene Ontology 10
    Phenotypes 24
  • Earliest
    J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
  • Latest
    J:322182 Chen Z, et al., Nuclear DEK preserves hematopoietic stem cells potential via NCoR1/HDAC3-Akt1/2-mTOR axis. J Exp Med. 2021 May 3;218(5)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
05/30/2023
MGI 6.22
The Jackson Laboratory