Dek MGI Mouse Gene Detail - MGI:1926209 - DEK proto-oncogene (DNA binding)

Symbol

Dek
Name

DEK proto-oncogene (DNA binding)
Synonyms

1810019E15Rik, D13H6S231E

Feature Type

protein coding gene
IDs

MGI:1926209
NCBI Gene: 110052
Alliance

gene page
Transcription Start Sites

18 TSS

Sequence Map

Chr13:47238251-47259677 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 24.50 cM, cytoband B1
Mapping Data

5 experiments

SNPs within 2kb

123 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1926209	protein coding gene	Chr13:47238243-47261134 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020520	protein coding gene	Chr13:45894054-45915471 (-)
A/J	MGP_AJ_G0020474	protein coding gene	Chr13:44292028-44313564 (-)
AKR/J	MGP_AKRJ_G0020451	protein coding gene	Chr13:45505778-45527204 (-)
BALB/cJ	MGP_BALBcJ_G0020470	protein coding gene	Chr13:44497826-44519243 (-)
C3H/HeJ	MGP_C3HHeJ_G0020269	protein coding gene	Chr13:45370123-45391539 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020903	protein coding gene	Chr13:47277865-47299291 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018488	protein coding gene	Chr13:42338203-42360026 (-)
CAST/EiJ	MGP_CASTEiJ_G0019784	protein coding gene	Chr13:45310932-45332273 (-)
CBA/J	MGP_CBAJ_G0020230	protein coding gene	Chr13:49239143-49260722 (-)
DBA/2J	MGP_DBA2J_G0020352	protein coding gene	Chr13:43844738-43866155 (-)
FVB/NJ	MGP_FVBNJ_G0020331	protein coding gene	Chr13:43362649-43384087 (-)
LP/J	MGP_LPJ_G0020427	protein coding gene	Chr13:46117723-46139140 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020360	protein coding gene	Chr13:49058933-49082667 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020946	protein coding gene	Chr13:45214892-45236329 (-)
PWK/PhJ	MGP_PWKPhJ_G0019540	protein coding gene	Chr13:43980546-44002355 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019368	protein coding gene	Chr13:43882134-43904504 (-)
WSB/EiJ	MGP_WSBEiJ_G0019846	protein coding gene	Chr13:45518909-45540337 (-)

Human Ortholog

DEK, DEK proto-oncogene

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DEK, DEK proto-oncogene
Synonyms

D6S231E
Links

HGNC:2768

NCBI Gene ID: 7913

neXtProt AC: NX_P35659

UniProt: P35659
Chr Location

6p22.3; chr6:18224169-18264568 (-) GRCh38.p7

Alliance of Genome Resources

Dek stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DEK
Gene Tree

Dek

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
6 phenotypes from multigenic genotypes
24 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

45
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

36
Targeted

5
Transgenic

2
Genomic Mutations

1 involving Dek
Incidental Mutations

Mutagenetix
Find Mice (IMSR)

24 strains or lines available

Mice homozygous for a null allele exhibit delayed development of DMBA- and TPA-induced papillomas.

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All GO Annotations

22
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

730
Tissues

19
cDNA Data

227
Literature Summary

7

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dek

ZFIN dek

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Dek interacts with 259 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

56
RefSeq

5
UniProt

7
CCDS

CCDS26490.1

Ensembl

ENSMUSG00000021377 (Evidence)
NCBI Gene

110052

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021377	Ensembl Gene Model \| MGI Sequence Detail	21427	C57BL/6J	± kb
transcript	ENSMUST00000021807	Ensembl \| MGI Sequence Detail	2556	Not Applicable
polypeptide	ENSMUSP00000021807	Ensembl \| MGI Sequence Detail	380	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000006415 protein DEK

(term hierarchy)
InterPro Domains

IPR014876 DEK, C-terminal

IPR044198 Protein DEK

IPR003034 SAP domain

IPR036361 SAP domain superfamily

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All nucleic 230

cDNA 228

Primer pair 2

Microarray probesets 3

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MGD-MRK-3410, MGI:1914254, MGI:89627

Summaries

All 67

Developmental Gene Expression 7

Gene Ontology 10

Phenotypes 24
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:322182 Chen Z, et al., Nuclear DEK preserves hematopoietic stem cells potential via NCoR1/HDAC3-Akt1/2-mTOR axis. J Exp Med. 2021 May 3;218(5)

TSS for Dek:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr122380	Chr13:47259698-47259709 (-)	-27 bp
Tssr122379	Chr13:47259685-47259697 (-)	-14 bp
Tssr122378	Chr13:47259652-47259682 (-)	10 bp
Tssr122377	Chr13:47259620-47259647 (-)	43 bp
Tssr122376	Chr13:47259595-47259604 (-)	77 bp
Tssr122375	Chr13:47259577-47259586 (-)	95 bp
Tssr122374	Chr13:47259266-47259351 (-)	368 bp
Tssr122373	Chr13:47259209-47259223 (-)	461 bp
Tssr122372	Chr13:47259160-47259178 (-)	508 bp
Tssr122371	Chr13:47259084-47259098 (-)	586 bp
Tssr122370	Chr13:47258997-47259000 (-)	678 bp
Tssr122369	Chr13:47258850-47258853 (-)	825 bp
Tssr122368	Chr13:47253744-47253749 (-)	5,930 bp
Tssr122367	Chr13:47253695-47253729 (-)	5,965 bp
Tssr122366	Chr13:47253681-47253692 (-)	5,990 bp
Tssr122365	Chr13:47252873-47252910 (-)	6,785 bp
Tssr122364	Chr13:47252848-47252863 (-)	6,821 bp
Tssr122363	Chr13:47251717-47251752 (-)	7,942 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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