Pigt MGI Mouse Gene Detail - MGI:1926178 - phosphatidylinositol glycan anchor biosynthesis, class T

Symbol

Pigt
Name

phosphatidylinositol glycan anchor biosynthesis, class T
Synonyms

2510012P17Rik, 4930534E15Rik, CGI-06, NDAP, Ndap7

Feature Type

protein coding gene
IDs

MGI:1926178
NCBI Gene: 78928
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr2:164339461-164350221 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 85.17 cM, cytoband H3
Mapping Data

2 experiments

SNPs within 2kb

403 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1926178	protein coding gene	Chr2:164339440-164350221 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026856	protein coding gene	Chr2:169946124-169958227 (+)
A/J	MGP_AJ_G0026822	protein coding gene	Chr2:163027082-163037618 (+)
AKR/J	MGP_AKRJ_G0026793	protein coding gene	Chr2:167867486-167880269 (+)
BALB/cJ	MGP_BALBcJ_G0026831	protein coding gene	Chr2:163388895-163399898 (+)
C3H/HeJ	MGP_C3HHeJ_G0026573	protein coding gene	Chr2:168223060-168233637 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027279	protein coding gene	Chr2:174872107-174888720 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024649	protein coding gene	Chr2:156436531-156446891 (+)
CAST/EiJ	MGP_CASTEiJ_G0026033	protein coding gene	Chr2:168645115-168656926 (+)
CBA/J	MGP_CBAJ_G0026550	protein coding gene	Chr2:181216517-181227285 (+)
DBA/2J	MGP_DBA2J_G0026688	protein coding gene	Chr2:162197421-162207990 (+)
FVB/NJ	MGP_FVBNJ_G0026654	protein coding gene	Chr2:160612400-160623514 (+)
LP/J	MGP_LPJ_G0026791	protein coding gene	Chr2:170027176-170037770 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026674	protein coding gene	Chr2:184803539-184817025 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027335	protein coding gene	Chr2:167769695-167780279 (+)
PWK/PhJ	MGP_PWKPhJ_G0025768	protein coding gene	Chr2:161775831-161787152 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025571	protein coding gene	Chr2:166641763-166653948 (+)
WSB/EiJ	MGP_WSBEiJ_G0026104	protein coding gene	Chr2:168637746-168648279 (+)

Human Ortholog

PIGT, phosphatidylinositol glycan anchor biosynthesis class T

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PIGT, phosphatidylinositol glycan anchor biosynthesis class T
Synonyms

CGI-06, MCAHS3, NDAP, PIG-T, PNH2
Links

HGNC:14938

NCBI Gene ID: 51604

UniProt: Q969N2
Chr Location

20q13.12; chr20:45416084-45456934 (+) GRCh38

MGI Vertebrate Homology

Pigt stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PIGT
Gene Tree

Pigt

Diseases

2 with human PIGT associations

				Human Disease	Mouse Models
				multiple congenital anomalies-hypotonia-seizures syndrome 3 IDs multiple congenital anomalies-hypotonia-seizures syndrome 3 DOID:0080140 OMIM:615398
				paroxysmal nocturnal hemoglobinuria IDs paroxysmal nocturnal hemoglobinuria DOID:0060284 ICD10CM:D59.5 ICD10CM:D59.6 MESH:D006457 NCI:C61233 OMIM:300818 OMIM:615399 ORDO:447 UMLS_CUI:C0019050 UMLS_CUI:C0024790 UMLS_CUI:C0086774

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
4 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

2
Targeted

3
Find Mice (IMSR)

41 strains or lines available

Mice homozygous for a null mutation do not survive.

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All GO Annotations

7
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

800
Tissues

94
cDNA Data

70
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pigt

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All Sequences

63
RefSeq

8
UniProt

5
CCDS

CCDS17038.2, CCDS89578.1

Ensembl

ENSMUSG00000017721 (Evidence)
NCBI Gene

78928

			Length	Strain/Species	Flank
genomic	78928	NCBI Gene Model \| MGI Sequence Detail	10761	C57BL/6J	± kb
transcript	NM_001378795	RefSeq \| MGI Sequence Detail	2650	C57BL/6
polypeptide	Q8BXQ2	UniProt \| EBI \| MGI Sequence Detail	582	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000012707 GPI transamidase component PIG-T

(term hierarchy)
InterPro Domains

IPR007245 GPI transamidase component PIG-T
GlyGen

Q8BXQ2 5 sites, 3 N-linked glycans (2 sites), 1 O-linked glycan (1 site)

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All nucleic 70

cDNA 70

Microarray probesets 6

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MGI:1919706

Summaries

All 28

Developmental Gene Expression 1

Gene Ontology 3

Phenotypes 4
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:161922 Tang T, et al., A mouse knockout library for secreted and transmembrane proteins. Nat Biotechnol. 2010 Jul;28(7):749-55

TSS for Pigt:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr21604	Chr2:164339438-164339480 (+)	-2 bp
Tssr21605	Chr2:164339881-164339904 (+)	432 bp
Tssr21606	Chr2:164343422-164343436 (+)	3,968 bp
Tssr21607	Chr2:164344497-164344516 (+)	5,046 bp
Tssr21608	Chr2:164344540-164344556 (+)	5,087 bp
Tssr21609	Chr2:164349312-164349353 (+)	9,872 bp
Tssr21610	Chr2:164350168-164350178 (+)	10,712 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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