Coro7 MGI Mouse Gene Detail - MGI:1926135

Symbol

Coro7
Name

coronin 7
Synonyms

0610011B16Rik

Feature Type

protein coding gene
IDs

MGI:1926135
NCBI Gene: 78885
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr16:4444748-4497584 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 2.45 cM, cytoband A1
Mapping Data

4 experiments

SNPs within 2kb

199 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1926135	protein coding gene	Chr16:4443997-4497641 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022467	protein coding gene	Chr16:1127426-1184436 (-)
A/J	MGP_AJ_G0022429	protein coding gene	Chr16:952803-1006085 (-)
AKR/J	MGP_AKRJ_G0022406	protein coding gene	Chr16:1135903-1198533 (-)
BALB/cJ	MGP_BALBcJ_G0022434	protein coding gene	Chr16:1106369-1161518 (-)
C3H/HeJ	MGP_C3HHeJ_G0022201	protein coding gene	Chr16:1157074-1217485 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022883	protein coding gene	Chr16:1206567-1266584 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020404	protein coding gene	Chr16:894511-950070 (-)
CAST/EiJ	MGP_CASTEiJ_G0021727	protein coding gene	Chr16:1145564-1210819 (-)
CBA/J	MGP_CBAJ_G0022170	protein coding gene	Chr16:1268578-1326104 (-)
DBA/2J	MGP_DBA2J_G0022301	protein coding gene	Chr16:1063644-1118238 (-)
FVB/NJ	MGP_FVBNJ_G0022276	protein coding gene	Chr16:1048990-1102161 (-)
LP/J	MGP_LPJ_G0022369	protein coding gene	Chr16:1131086-1184543 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022298	protein coding gene	Chr16:1141001-1194699 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022895	protein coding gene	Chr16:1105450-1161049 (-)
PWK/PhJ	MGP_PWKPhJ_G0021467	protein coding gene	Chr16:1124024-1179750 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021298	protein coding gene	Chr16:1195002-1256538 (-)
WSB/EiJ	MGP_WSBEiJ_G0021776	protein coding gene	Chr16:1118446-1179115 (-)

Human Ortholog

CORO7, coronin 7

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CORO7, coronin 7
Synonyms

0610011B16Rik, CRN7, POD1
Links

HGNC:26161

NCBI Gene ID: 79585

neXtProt AC: NX_P57737

UniProt: P57737
Chr Location

16p13.3; chr16:4354542-4425705 (-) GRCh38

Human Ortholog

CORO7-PAM16, CORO7-PAM16 readthrough
Synonyms

CORO7, Coronin-7, Crn7
Links

HGNC:44424

NCBI Gene ID: 100529144
Chr Location

16p13.3; chr16:4340251-4420494 (-) GRCh38

MGI Vertebrate Homology

Coro7 stringent orthology
2 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CORO7, CORO7-PAM16
Gene Tree

Coro7

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Gene trapped

7
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

55 strains or lines available

Mice homozygous for a knock-out allele are viable and overtly normal but exhibit disruption of the Golgi apparatus. Mutant fibroblasts show increased cell spreading and cellular F-actin content, increased cell polarization and migration, and enhanced wound healing in a scratch-wound assay.

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All GO Annotations

18
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

793
Tissues

23
cDNA Data

69
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase coro7

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All Sequences

71
RefSeq

2
UniProt

5
CCDS

CCDS37242.1

Ensembl

ENSMUSG00000039637 (Evidence)
NCBI Gene

78885

			Length	Strain/Species	Flank
genomic	78885	NCBI Gene Model \| MGI Sequence Detail	52837	C57BL/6J	± kb
transcript	NM_030205	RefSeq \| MGI Sequence Detail	3518	Not Specified
polypeptide	Q9D2V7	UniProt \| EBI \| MGI Sequence Detail	922	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000005766 coronin-7

(term hierarchy)
InterPro Domains

IPR015505 Coronin

IPR015048 Domain of unknown function DUF1899

IPR020472 G-protein beta WD-40 repeat

IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily

IPR001680 WD40 repeat

IPR019775 WD40 repeat, conserved site

IPR036322 WD40-repeat-containing domain superfamily

IPR015943 WD40/YVTN repeat-like-containing domain superfamily

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All nucleic 72

cDNA 70

Other 2

Microarray probesets 8

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MGI:2146615, MGI:2146667

Summaries

All 37

Developmental Gene Expression 4

Gene Ontology 8

Phenotypes 6
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:235774 Bhattacharya K, et al., Novel Coronin7 interactions with Cdc42 and N-WASP regulate actin organization and Golgi morphology. Sci Rep. 2016;6:25411

TSS for Coro7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr139787	Chr16:4497567-4497611 (-)	-5 bp
Tssr139786	Chr16:4497524-4497563 (-)	40 bp
Tssr139785	Chr16:4488395-4488445 (-)	9,164 bp
Tssr139784	Chr16:4453277-4453317 (-)	44,287 bp
Tssr139783	Chr16:4452240-4452290 (-)	45,319 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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