Vsig1 MGI Mouse Gene Detail - MGI:1926039 - V-set and immunoglobulin domain containing 1

Symbol

Vsig1
Name

V-set and immunoglobulin domain containing 1
Synonyms

1700062D20Rik, 4930405J24Rik

Feature Type

protein coding gene
IDs

MGI:1926039
NCBI Gene: 78789
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

ChrX:139808357-139840221 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 61.62 cM, cytoband F1
Mapping Data

2 experiments

SNPs within 2kb

83 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1926039	protein coding gene	ChrX:139808357-139840221 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0036138	protein coding gene	ChrX:138482600-138515954 (+)
A/J	MGP_AJ_G0036116	protein coding gene	ChrX:137849515-137881610 (+)
AKR/J	MGP_AKRJ_G0036041	protein coding gene	ChrX:142275124-142309740 (+)
BALB/cJ	MGP_BALBcJ_G0036106	protein coding gene	ChrX:136154562-136186394 (+)
C3H/HeJ	MGP_C3HHeJ_G0035815	protein coding gene	ChrX:138483433-138515347 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0036631	protein coding gene	ChrX:142510446-142543888 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033455	protein coding gene	ChrX:129542839-129577541 (+)
CAST/EiJ	MGP_CASTEiJ_G0035106	protein coding gene	ChrX:119308066-119344303 (+)
CBA/J	MGP_CBAJ_G0035792	protein coding gene	ChrX:146919246-146953477 (+)
DBA/2J	MGP_DBA2J_G0035949	protein coding gene	ChrX:136979988-137012381 (+)
FVB/NJ	MGP_FVBNJ_G0035883	protein coding gene	ChrX:136210346-136242530 (+)
LP/J	MGP_LPJ_G0036040	protein coding gene	ChrX:139416528-139455709 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035920	protein coding gene	ChrX:154429690-154467747 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036667	protein coding gene	ChrX:137787849-137822464 (+)
PWK/PhJ	MGP_PWKPhJ_G0034799	protein coding gene	ChrX:116195515-116228010 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0034625	protein coding gene	ChrX:119846240-119878162 (+)
WSB/EiJ	MGP_WSBEiJ_G0035241	protein coding gene	ChrX:136103230-136137411 (+)

Human Ortholog

VSIG1, V-set and immunoglobulin domain containing 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

VSIG1, V-set and immunoglobulin domain containing 1
Synonyms

1700062D20Rik, dJ889N15.1, GPA34
Links

HGNC:28675

NCBI Gene ID: 340547

neXtProt AC: NX_Q86XK7

UniProt: Q86XK7
Chr Location

Xq22.3; chrX:108018879-108079184 (+) GRCh38

Alliance of Genome Resources

Vsig1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: VSIG1
Gene Tree

Vsig1

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

3
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

12 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Male chimeras hemizygous for a knock-out allele exhibit abnormal differentiation of gastric epithelia.

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All GO Annotations

8
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development	DNA-templated transcription

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

777
Tissues

23
cDNA Data

15
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase vsig1

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Vsig1 interacts with 245 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

47
RefSeq

8
UniProt

3
CCDS

CCDS30443.1

Ensembl

ENSMUSG00000031430 (Evidence)
NCBI Gene

78789

			Length	Strain/Species	Flank
genomic	78789	NCBI Gene Model \| MGI Sequence Detail	31865	C57BL/6J	± kb
transcript	NM_001359143	RefSeq \| MGI Sequence Detail	2815	C57BL/6
polypeptide	Q9D2J4	UniProt \| EBI \| MGI Sequence Detail	407	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000031390 V-set and immunoglobulin domain-containing protein 1

(term hierarchy)
InterPro Domains

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR003598 Immunoglobulin subtype 2

IPR013106 Immunoglobulin V-set domain

IPR000920 Myelin P0 protein-related

IPR029861 V-set and immunoglobulin domain-containing protein 1

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All nucleic 19

cDNA 15

Primer pair 4

Microarray probesets 3

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MGI:1914597

Summaries

All 34

Developmental Gene Expression 4

Gene Ontology 4

Phenotypes 6
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:307545 Jung Y, et al., V-Set and Immunoglobulin Domain-Containing 1 (VSIG1), Predominantly Expressed in Testicular Germ Cells, Is Dispensable for Spermatogenesis and Male Fertility in Mice. Animals (Basel). 2021 Apr 7;11(4)

TSS for Vsig1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr162212	ChrX:139808260-139808282 (+)	-86 bp
Tssr162213	ChrX:139808303-139808306 (+)	-52 bp
Tssr162214	ChrX:139808351-139808384 (+)	11 bp
Tssr162215	ChrX:139823917-139823920 (+)	15,562 bp
Tssr162216	ChrX:139823927-139823930 (+)	15,572 bp
Tssr162217	ChrX:139823942-139823958 (+)	15,593 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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