Celf3 MGI Mouse Gene Detail - MGI:1926034 - CUGBP, Elav-like family member 3

Symbol

Celf3
Name

CUGBP, Elav-like family member 3
Synonyms

4930415M08Rik, BRUNOL1, CAGH4, ERDA4, Tnrc4

Feature Type

protein coding gene
IDs

MGI:1926034
NCBI Gene: 78784
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr3:94385602-94399505 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 40.73 cM
Mapping Data

2 experiments

SNPs within 2kb

97 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1926034	protein coding gene	Chr3:94385581-94405822 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027553	protein coding gene	Chr3:95057305-95071174 (+)
A/J	MGP_AJ_G0027512	protein coding gene	Chr3:92166055-92179795 (+)
AKR/J	MGP_AKRJ_G0027480	protein coding gene	Chr3:94260874-94274746 (+)
BALB/cJ	MGP_BALBcJ_G0027523	protein coding gene	Chr3:91875702-91889595 (+)
C3H/HeJ	MGP_C3HHeJ_G0027259	protein coding gene	Chr3:94564816-94579706 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027972	protein coding gene	Chr3:98642057-98657217 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025314	protein coding gene	Chr3:88656015-88670157 (+)
CAST/EiJ	MGP_CASTEiJ_G0026707	protein coding gene	Chr3:93901123-93917095 (+)
CBA/J	MGP_CBAJ_G0027235	protein coding gene	Chr3:102144331-102158085 (+)
DBA/2J	MGP_DBA2J_G0027374	protein coding gene	Chr3:91429619-91443653 (+)
FVB/NJ	MGP_FVBNJ_G0027344	protein coding gene	Chr3:89527239-89542015 (+)
LP/J	MGP_LPJ_G0027482	protein coding gene	Chr3:96364162-96379043 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027371	protein coding gene	Chr3:108372167-108388951 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028026	protein coding gene	Chr3:93936174-93950060 (+)
PWK/PhJ	MGP_PWKPhJ_G0026435	protein coding gene	Chr3:91318981-91332479 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026256	protein coding gene	Chr3:92279600-92293427 (+)
WSB/EiJ	MGP_WSBEiJ_G0026790	protein coding gene	Chr3:94290119-94303848 (+)

Human Ortholog

CELF3, CUGBP Elav-like family member 3

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CELF3, CUGBP Elav-like family member 3
Synonyms

BRUNOL1, CAGH4, ERDA4, ETR-1, TNRC4
Links

HGNC:11967

NCBI Gene ID: 11189

neXtProt AC: NX_Q5SZQ8

UniProt: Q5SZQ8
Chr Location

1q21.3; chr1:151700058-151716803 (-) GRCh38

MGI Vertebrate Homology

Celf3 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CELF3
Gene Tree

Celf3

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References

1 with disease annotations

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Endonuclease-mediated

2
Radiation induced

1
Targeted

1
Genomic Mutations

2 involving Celf3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

25 strains or lines available

Male mice homozygous for a null mutation display reduced sperm counts and motility but are fertile.

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All GO Annotations

23
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

909
Tissues

49
cDNA Data

31
Literature Summary

9

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase celf3

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All Sequences

138
RefSeq

77
UniProt

7
CCDS

CCDS38536.1, CCDS79972.1, CCDS79973.1, CCDS79974.1

Ensembl

ENSMUSG00000028137 (Evidence)
NCBI Gene

78784

			Length	Strain/Species	Flank
genomic	ENSMUSG00000028137	Ensembl Gene Model \| MGI Sequence Detail	13904	C57BL/6J	± kb
transcript	ENSMUST00000200342	Ensembl \| MGI Sequence Detail	3173	Not Applicable
polypeptide	ENSMUSP00000143344	Ensembl \| MGI Sequence Detail	494	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000016517 CUGBP Elav-like family member 3

(term hierarchy)
InterPro Domains

IPR034648 CELF-3/4/5/6, RNA recognition motif 1

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR035979 RNA-binding domain superfamily

IPR000504 RNA recognition motif domain

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All nucleic 33

cDNA 32

Primer pair 1

Microarray probesets 2

Summaries

All 36

Developmental Gene Expression 9

Diseases 1

Gene Ontology 5

Phenotypes 6
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034

TSS for Celf3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr30451	Chr3:94385629-94385650 (+)	38 bp
Tssr30452	Chr3:94385661-94385673 (+)	65 bp
Tssr30453	Chr3:94386435-94386456 (+)	844 bp
Tssr30454	Chr3:94391631-94391642 (+)	6,035 bp
Tssr30455	Chr3:94391645-94391658 (+)	6,050 bp
Tssr30456	Chr3:94391676-94391715 (+)	6,094 bp
Tssr30457	Chr3:94393611-94393612 (+)	8,010 bp
Tssr30458	Chr3:94393639-94393640 (+)	8,038 bp
Tssr30459	Chr3:94394997-94395013 (+)	9,403 bp
Tssr30460	Chr3:94395040-94395058 (+)	9,447 bp
Tssr30461	Chr3:94399389-94399407 (+)	13,796 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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