Platr4 Gene Detail

Summary

• Symbol
  Platr4
• Name
  pluripotency associated transcript 4
• Synonyms
  C430002E04Rik

• Feature Type
  lncRNA gene
• IDs
  MGI:1925956
  NCBI Gene: 78706
• Alliance
  genome feature page
• Transcription Start Sites
  1 TSS

Location &
Maps

• Sequence Map
  Chr3:41442116-41447634 bp, - strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 3, 19.85 cM
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  242 from dbSNP Build 142
• Strain Annotations
  19

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1925956	lncRNA gene	Chr3:41339324-41490599 (-)
129S1/SvImJ	ENSMUSG00200006620	lncRNA gene	Chr3:38152275-38184349 (-)
A/J	ENSMUSG00195001496	lncRNA gene	Chr3:38136656-38168749 (-)
AKR/J	ENSMUSG00220000707	lncRNA gene	Chr3:38225733-38257803 (-)
BALB/cJ	ENSMUSG00180002688	lncRNA gene	Chr3:38263779-38295853 (-)
C3H/HeJ	ENSMUSG00175003455	lncRNA gene	Chr3:38134512-38166589 (-)
C57BL/6NJ	ENSMUSG00215001513	lncRNA gene	Chr3:38553427-38585497 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0005616	lincRNA gene	Chr3:36030722-36039798 (-)
CAST/EiJ	ENSTCUG00005001317	lncRNA gene	Chr3:38010320-38042536 (-)
CBA/J	ENSMUSG00210001926	lncRNA gene	Chr3:38229967-38262041 (-)
DBA/2J	ENSMUSG00185001513	lncRNA gene	Chr3:38426531-38458605 (-)
FVB/NJ	ENSMUSG00205000861	lncRNA gene	Chr3:37552606-37584667 (-)
JF1/MsJ	ENSUMUG00000001293	lncRNA gene	Chr3:37934646-37966174 (-)
LP/J	ENSMUSG00230023994	lncRNA gene	Chr3:40393240-40425316 (-)
NOD/ShiLtJ	ENSMUSG00190001736	lncRNA gene	Chr3:38489636-38521700 (-)
NZO/HlLtJ	ENSMUSG00225000936	lncRNA gene	Chr3:43014207-43046283 (-)
PWK/PhJ	ENSLUMG00010000890	lncRNA gene	Chr3:37981187-38012707 (-)
SPRET/EiJ	ENSMSPG00010000713	lncRNA gene	Chr3:38418610-38450261 (-)
WSB/EiJ	ENSIUOG00005014519	lncRNA gene	Chr3:38417187-38449312 (-)

Homology

• Gene Tree
  Platr4
  

Human Diseases

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  11 phenotypes from 1 allele in 1 genetic background
  11 phenotype references
  

• All Mutations and Alleles
  12
• Endonuclease-mediated
  2
• Gene trapped
  8
• Radiation induced
  2
• Genomic Mutations
  2 involving Platr4
• Find Mice (IMSR)
  0 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Homozygous null mice exhibit myocardial atrophy, valve mucinous degeneration, left ventricular hypertrophy, reduced cardiac output and heart rate, with 60% showing sudden heart failure.

Expression

• Assay Results
  620
• Tissues
  19
• cDNA Data
  4
• Literature Summary
  2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  270
• RefSeq
  1

• Ensembl
  ENSMUSG00000097639 (Evidence)
• NCBI Gene
  78706

Representative Sequences			Length	Strain/Species
genomic	78706	NCBI Gene Model | MGI Sequence Detail	5519	C57BL/6J
transcript	NR_040385	RefSeq | MGI Sequence Detail	2168	C57BL/6

Molecular
Reagents

• All nucleic 7

  cDNA 4

  Primer pair 2

  Other 1

  
  

  Microarray probesets 1

References

• Summaries
  All 25

  Developmental Gene Expression 2

  Diseases 1

  Phenotypes 11
• Earliest
  J:64276 Lyon MF, et al., Dose-response curves for radiation-induced gene mutations in mouse oocytes and their interpretation. Mutat Res. 1979 Nov;63(1):161-73
• Latest
  J:331476 Hazra R, et al., Platr4 is an early embryonic lncRNA that exerts its function downstream on cardiogenic mesodermal lineage commitment. Dev Cell. 2022 Nov 7;57(21):2450-2468.e7

TSS for Platr4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr33075	Chr3:41447612-41447637 (-)	9 bp