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Marchf2 Gene Detail
Summary
  • Symbol
    Marchf2
  • Name
    membrane associated ring-CH-type finger 2
  • Synonyms
    9530046H09Rik, March2, MGC:7259
  • Feature Type
    protein coding gene
  • IDs
    MGI:1925915
    NCBI Gene: 224703
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:33904666-33937644 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 17.98 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4 from dbSNP Build 142
  • Strain Annotations
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1925915
 protein coding gene Chr17:33904666-33937651 (-)
129S1/SvImJ ENSMUSG00200052566
 protein coding gene Chr17:29607514-29640495 (-)
A/J ENSMUSG00195050345
 protein coding gene Chr17:30478848-30511905 (-)
AKR/J ENSMUSG00220049298
 protein coding gene Chr17:29506483-29539521 (-)
BALB/cJ ENSMUSG00180049262
 protein coding gene Chr17:29865327-29898390 (-)
C3H/HeJ ENSMUSG00175053306
 protein coding gene Chr17:29387860-29420904 (-)
C57BL/6NJ ENSMUSG00215053987
 protein coding gene Chr17:29447677-29480660 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021414
 protein coding gene Chr17:29976994-30006378 (-)
CAST/EiJ no annotation
CBA/J ENSMUSG00210043429
 protein coding gene Chr17:29214800-29247836 (-)
DBA/2J ENSMUSG00185052453
 protein coding gene Chr17:31884641-31917694 (-)
FVB/NJ ENSMUSG00205051891
 protein coding gene Chr17:29745506-29778502 (-)
JF1/MsJ no annotation
LP/J ENSMUSG00230053506
 protein coding gene Chr17:33005901-33038881 (-)
NOD/ShiLtJ ENSMUSG00190052891
 protein coding gene Chr17:29367680-29400666 (-)
NZO/HlLtJ ENSMUSG00225054429
 protein coding gene Chr17:35036054-35069190 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    MARCHF2, membrane associated ring-CH-type finger 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MARCHF2, membrane associated ring-CH-type finger 2
  • Synonyms
    HSPC240, MARCH2, MARCH-II, RNF172
  • Links
    NCBI Gene ID: 51257
    UniProt: Q9P0N8

  • Chr Location
    19p13.2; chr19:8411460-8439017 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit resistance to bacterial and viral infection with reduced bacterial or viral load and increased cytokine production in addition to increased lethality induced by LPS treatment.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    40
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    760
  • Tissues
    32
  • cDNA Data
    14
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000079557 Ensembl Gene Model | MGI Sequence Detail 32979 C57BL/6J ±  kb
    transcript ENSMUST00000066121 Ensembl | MGI Sequence Detail 3400 Not Applicable  
    polypeptide ENSMUSP00000065225 Ensembl | MGI Sequence Detail 287 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 14
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:6368850
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 3
      Gene Ontology 9
      Phenotypes 12
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:384912 Ma ZW, et al., MARCH2 mediates K27-Linked polyubiquitination of IL-2 receptor alpha to negatively regulate T cell proliferation. J Immunol. 2026 Apr 15;215(4)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory