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Htra3 Gene Detail
Summary
  • Symbol
    Htra3
  • Name
    HtrA serine peptidase 3
  • Synonyms
    2210021K23Rik, 9530081K03Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1925808
    NCBI Gene: 78558
  • Alliance
    genome feature page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:35809367-35837126 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 18.49 cM, cytoband B1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    896 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1925808
 protein coding gene Chr5:35809367-35837157 (-)
129S1/SvImJ ENSMUSG00200031856
 protein coding gene Chr5:31278592-31306484 (-)
A/J ENSMUSG00195027346
 protein coding gene Chr5:30752606-30780507 (-)
AKR/J ENSMUSG00220002256
 protein coding gene Chr5:30779400-30807298 (-)
BALB/cJ ENSMUSG00180031124
 protein coding gene Chr5:30555489-30583385 (-)
C3H/HeJ ENSMUSG00175019697
 protein coding gene Chr5:32535006-32562906 (-)
C57BL/6NJ ENSMUSG00215005230
 protein coding gene Chr5:31275834-31303725 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027150
 protein coding gene Chr5:30596314-30623520 (-)
CAST/EiJ ENSTCUG00005023357
 protein coding gene Chr5:30757129-30784907 (-)
CBA/J ENSMUSG00210003736
 protein coding gene Chr5:31503826-31531721 (-)
DBA/2J ENSMUSG00185016322
 protein coding gene Chr5:33370972-33398848 (-)
FVB/NJ ENSMUSG00205035162
 protein coding gene Chr5:30251305-30279179 (-)
JF1/MsJ ENSUMUG00000040663
 protein coding gene Chr5:37969275-37997080 (-)
LP/J ENSMUSG00230041456
 protein coding gene Chr5:37982209-38010100 (-)
NOD/ShiLtJ ENSMUSG00190002689
 protein coding gene Chr5:30533311-30561229 (-)
NZO/HlLtJ ENSMUSG00225015291
 protein coding gene Chr5:43185568-43213472 (-)
PWK/PhJ ENSLUMG00010021609
 protein coding gene Chr5:30663295-30691074 (-)
SPRET/EiJ ENSMSPG00010032965
 protein coding gene Chr5:31877600-31904873 (-)
WSB/EiJ ENSIUOG00005017168
 protein coding gene Chr5:33460040-33487989 (-)



Homology
more
  • Human Ortholog
    HTRA3, HtrA serine peptidase 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HTRA3, HtrA serine peptidase 3
  • Synonyms
    Prsp, Tasp
  • Links
    NCBI Gene ID: 94031
    UniProt: P83110

  • Chr Location
    4p16.1; chr4:8269749-8307110 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    31 phenotype references
  • All Mutations and Alleles
    16
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    4
  • Radiation induced
    4
  • Spontaneous
    1
  • Targeted
    4
  • Genomic Mutations
    8 involving Htra3
  • Incidental Mutations
    Mutagenetix , APF , CvDC
  • Find Mice (IMSR)
    21 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    626
  • Tissues
    12
  • cDNA Data
    70
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029096 Ensembl Gene Model | MGI Sequence Detail 27760 C57BL/6J ±  kb
transcript ENSMUST00000087629 Ensembl | MGI Sequence Detail 2750 Not Applicable  
polypeptide ENSMUSP00000084910 Ensembl | MGI Sequence Detail 459 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 71
    cDNA 70
    Primer pair 1

    Microarray probesets 7
Other
Accession IDs
less
MGI:1921510
References
more
  • Summaries
    All 66
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 8
    Phenotypes 31
  • Earliest
    J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory