Plscr1l1 MGI Mouse Gene Detail - MGI:1925709 - phospholipid scramblase 1 like 1

Symbol

Plscr1l1
Name

phospholipid scramblase 1 like 1
Synonyms

1700057G04Rik

Feature Type

protein coding gene
IDs

MGI:1925709
NCBI Gene: 78459
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr9:92191430-92239929 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 48.36 cM
Mapping Data

1 experiment

SNPs within 2kb

1700 from dbSNP Build 142
Strain Annotations

27

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1925709	protein coding gene	Chr9:92191379-92239929 (+)
129S1/SvImJ	ENSMUSGG00200054765	protein coding gene	Chr9:89350339-89350571 (+)
129S1/SvImJ	ENSMUSG00200005087	protein coding gene	Chr9:89354690-89364852 (+)
A/J	ENSMUSGG00195055306	protein coding gene	Chr9:88605254-88605486 (+)
AKR/J	ENSMUSG00220019705	protein coding gene	Chr9:88989882-89000039 (+)
AKR/J	ENSMUSGG00220054794	protein coding gene	Chr9:88985529-88985761 (+)
BALB/cJ	ENSMUSGG00180055413	protein coding gene	Chr9:88930979-88931211 (+)
C3H/HeJ	ENSMUSGG00175054810	protein coding gene	Chr9:89242373-89242605 (+)
C57BL/6NJ	ENSMUSG00215008209	protein coding gene	Chr9:89242064-89252222 (+)
C57BL/6NJ	ENSMUSGG00215055616	protein coding gene	Chr9:89237713-89237945 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032525	protein coding gene	Chr9:88143086-88193087 (+)
CAST/EiJ	no annotation
CBA/J	ENSMUSGG00210054907	protein coding gene	Chr9:89124694-89124926 (+)
CBA/J	ENSMUSG00210005482	protein coding gene	Chr9:89129046-89139233 (+)
DBA/2J	ENSMUSGG00185057507	protein coding gene	Chr9:89308076-89308308 (+)
DBA/2J	ENSMUSG00185001675	protein coding gene	Chr9:89312431-89322613 (+)
FVB/NJ	ENSMUSG00205004577	protein coding gene	Chr9:89448363-89458541 (+)
FVB/NJ	ENSMUSGG00205054565	protein coding gene	Chr9:89444008-89444240 (+)
JF1/MsJ	ENSUMUG00000015538	protein coding gene	Chr9:89026620-89036782 (+)
LP/J	ENSMUSG00230008487	protein coding gene	Chr9:89460668-89470833 (+)
LP/J	ENSMUSGG00230055710	protein coding gene	Chr9:89456317-89456549 (+)
NOD/ShiLtJ	ENSMUSGG00190055011	protein coding gene	Chr9:88900111-88900343 (+)
NOD/ShiLtJ	ENSMUSG00190010782	protein coding gene	Chr9:88904462-88914619 (+)
NZO/HlLtJ	ENSMUSGG00225055528	protein coding gene	Chr9:89605369-89605601 (+)
NZO/HlLtJ	ENSMUSG00225015750	protein coding gene	Chr9:89609705-89619865 (+)
PWK/PhJ	ENSLUMG00010002922	protein coding gene	Chr9:88994420-89004571 (+)
SPRET/EiJ	ENSMSPG00010002255	protein coding gene	Chr9:90751424-90773127 (+)
WSB/EiJ	ENSIUOG00005003562	protein coding gene	Chr9:88364739-88374928 (+)

Human Ortholog

PLSCR1, phospholipid scramblase 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PLSCR1, phospholipid scramblase 1
Synonyms

MMTRA1B
Links

HGNC:9092

NCBI Gene ID: 5359

UniProt: O15162
Chr Location

3q24; chr3:146511858-146544862 (-) GRCh38

Human Ortholog

PLSCR2, phospholipid scramblase 2
Links

HGNC:16494

NCBI Gene ID: 57047

UniProt: Q9NRY7
Chr Location

3q24; chr3:146391420-146495991 (-) GRCh38

MGI Vertebrate Homology

Plscr1l1 stringent orthology
2 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PLSCR1, PLSCR2
Gene Tree

Plscr1l1

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
3 phenotype references

All Mutations and Alleles

2
Chemically induced (other)

1
Endonuclease-mediated

1
Genomic Mutations

1 involving Plscr1l1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

16 strains or lines available

Males homozygous for a null allele show normal male fertility.

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All GO Annotations

29
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

6

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

58
RefSeq

9
UniProt

5
CCDS

CCDS23406.1

Ensembl

ENSMUSG00000074139 (Evidence)
NCBI Gene

78459

			Length	Strain/Species	Flank
genomic	ENSMUSG00000074139	Ensembl Gene Model \| MGI Sequence Detail	48500	C57BL/6J	± kb
transcript	ENSMUST00000098477	Ensembl \| MGI Sequence Detail	1052	Not Applicable
polypeptide	ENSMUSP00000096077	Ensembl \| MGI Sequence Detail	232	Not Applicable

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UniProt

5 Sequences
InterPro Domains

IPR005552 Scramblase

IPR025659 Tubby-like, C-terminal

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All nucleic 6

cDNA 6

Microarray probesets 2

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MGI:7514650

Summaries

All 22

Gene Ontology 3

Phenotypes 3
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:315008 Oyama Y, et al., CRISPR/Cas9-mediated genome editing reveals 12 testis-enriched genes dispensable for male fertility in mice. Asian J Androl. 2021 Jul 16;

TSS for Plscr1l1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr86516	Chr9:92191415-92191439 (+)	-3 bp
Tssr86517	Chr9:92191444-92191454 (+)	19 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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