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Tbcel Gene Detail
Summary
  • Symbol
    Tbcel
  • Name
    tubulin folding cofactor E-like
  • Synonyms
    E130107N23Rik, Lrrc35
  • Feature Type
    protein coding gene
  • IDs
    MGI:1925543
    NCBI Gene: 272589
  • Alliance
    genome feature page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:42323612-42383534 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 23.71 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1540 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1925543
 protein coding gene Chr9:42323612-42419105 (-)
129S1/SvImJ ENSMUSG00200039228
 protein coding gene Chr9:39397947-39493501 (-)
A/J ENSMUSG00195045010
 protein coding gene Chr9:39156270-39251819 (-)
AKR/J ENSMUSG00220042492
 protein coding gene Chr9:39244865-39340564 (-)
BALB/cJ ENSMUSG00180039179
 protein coding gene Chr9:39268020-39363570 (-)
C3H/HeJ ENSMUSG00175039170
 protein coding gene Chr9:39279871-39375416 (-)
C57BL/6NJ ENSMUSG00215020278
 protein coding gene Chr9:39242361-39337863 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032085
 protein coding gene Chr9:39285926-39387715 (-)
CAST/EiJ ENSTCUG00005041278
 protein coding gene Chr9:39237615-39331868 (-)
CBA/J ENSMUSG00210036768
 protein coding gene Chr9:39325607-39421177 (-)
DBA/2J ENSMUSG00185031413
 protein coding gene Chr9:39382548-39478233 (-)
FVB/NJ ENSMUSG00205038997
 protein coding gene Chr9:39644984-39740506 (-)
JF1/MsJ ENSUMUG00000030902
 protein coding gene Chr9:39432515-39527662 (-)
LP/J ENSMUSG00230030590
 protein coding gene Chr9:39688666-39784203 (-)
NOD/ShiLtJ ENSMUSG00190024396
 protein coding gene Chr9:39473876-39569396 (-)
NZO/HlLtJ ENSMUSG00225021507
 protein coding gene Chr9:39655282-39750821 (-)
PWK/PhJ ENSLUMG00010044268
 protein coding gene Chr9:39387190-39488896 (-)
SPRET/EiJ ENSMSPG00010032465
 protein coding gene Chr9:40158280-40251347 (-)
WSB/EiJ ENSIUOG00005042982
 protein coding gene Chr9:38889204-38984720 (-)



Homology
more
  • Human Ortholog
    TBCEL, tubulin folding cofactor E like
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TBCEL, tubulin folding cofactor E like
  • Synonyms
    El, LRRC35
  • Links
    NCBI Gene ID: 219899
    UniProt: Q5QJ74

  • Chr Location
    11q23.3; chr11:121024072-121090776 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    66
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 272589 NCBI Gene Model | MGI Sequence Detail 59923 C57BL/6J ±  kb
    transcript NM_173038 RefSeq | MGI Sequence Detail 4980 C57BL/6  
    polypeptide Q8C5W3 UniProt | EBI | MGI Sequence Detail 424 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000016130 tubulin-specific chaperone cofactor E-like protein
      (term hierarchy)
    • InterPro Domains
      IPR032675 Leucine-rich repeat domain superfamily
      IPR047991 Tubulin-specific chaperone cofactor E-like protein, ubiquitin-like domain
      IPR000626 Ubiquitin-like domain
      IPR029071 Ubiquitin-like domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 66
      cDNA 66

      Microarray probesets 6
    References
    more
    • Summaries
      All 36
      Gene Ontology 2
      Phenotypes 14
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory