Ddo MGI Mouse Gene Detail - MGI:1925528

Symbol

Ddo
Name

D-aspartate oxidase
Synonyms

5330420D20Rik, 5730402C02Rik

Feature Type

protein coding gene
IDs

MGI:1925528
NCBI Gene: 70503
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr10:40506007-40557843 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 22.00 cM, cytoband B1
Mapping Data

3 experiments

SNPs within 2kb

464 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1925528	protein coding gene	Chr10:40505933-40557847 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017165	protein coding gene	Chr10:39227237-39251901 (+)
A/J	MGP_AJ_G0017142	protein coding gene	Chr10:38138850-38160225 (+)
AKR/J	MGP_AKRJ_G0017102	protein coding gene	Chr10:38693997-38714105 (+)
BALB/cJ	MGP_BALBcJ_G0017104	protein coding gene	Chr10:38226221-38244880 (+)
C3H/HeJ	MGP_C3HHeJ_G0016925	protein coding gene	Chr10:39015111-39037951 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017563	protein coding gene	Chr10:40436935-40463101 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015259	protein coding gene	Chr10:36105743-36125819 (+)
CAST/EiJ	MGP_CASTEiJ_G0016504	protein coding gene	Chr10:39212196-39236527 (+)
CBA/J	MGP_CBAJ_G0016899	protein coding gene	Chr10:42273663-42294559 (+)
DBA/2J	MGP_DBA2J_G0017004	protein coding gene	Chr10:37660474-37680021 (+)
FVB/NJ	MGP_FVBNJ_G0016999	protein coding gene	Chr10:37154158-37174082 (+)
LP/J	MGP_LPJ_G0017081	protein coding gene	Chr10:39214762-39236909 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017029	protein coding gene	Chr10:43110069-43131767 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017600	protein coding gene	Chr10:38670657-38693417 (+)
PWK/PhJ	MGP_PWKPhJ_G0016284	protein coding gene	Chr10:37539764-37559571 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016068	protein coding gene	Chr10:38507266-38525826 (+)
WSB/EiJ	MGP_WSBEiJ_G0016567	protein coding gene	Chr10:39007058-39036932 (+)

Human Ortholog

DDO, D-aspartate oxidase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DDO, D-aspartate oxidase
Synonyms

DASOX, DASPO, DDO-1, DDO-2
Links

HGNC:2727

NCBI Gene ID: 8528

neXtProt AC: NX_Q99489

UniProt: Q99489
Chr Location

6q21; chr6:110388321-110415575 (-) GRCh38

MGI Vertebrate Homology

Ddo stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DDO
Protein SuperFamily

D-aa_oxidase
Gene Tree

Ddo

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Phenotype Summary

6 phenotypes from 2 alleles in 2 genetic backgrounds
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

3
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Ddo
Incidental Mutations

APF
Find Mice (IMSR)

14 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice are viable and fertile, but can display impaired male copulation, decreased autogrooming, increased body weight, and increased D-aspartate levels, depending on the mutant allele.

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All GO Annotations

30
GO References

18

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

854
Tissues

120
cDNA Data

23
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ddo

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All Sequences

72
RefSeq

19
UniProt

6
CCDS

CCDS23798.1, CCDS87992.1, CCDS87993.1, CCDS87994.1, CCDS87995.1

Ensembl

ENSMUSG00000063428 (Evidence)
NCBI Gene

70503

			Length	Strain/Species	Flank
genomic	ENSMUSG00000063428	Ensembl Gene Model \| MGI Sequence Detail	51837	C57BL/6J	± kb
transcript	ENSMUST00000019977	Ensembl \| MGI Sequence Detail	3000	Not Applicable
polypeptide	ENSMUSP00000019977	Ensembl \| MGI Sequence Detail	341	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000006351 D-aspartate oxidase

(term hierarchy)
EC

1.4.3.1
InterPro Domains

IPR023209 D-amino-acid oxidase

IPR006181 D-amino acid oxidase, conserved site

IPR006076 FAD dependent oxidoreductase

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All nucleic 26

cDNA 24

Primer pair 1

Other 1

Microarray probesets 5

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MGI:1917753, MGI:2143623

Summaries

All 56

Developmental Gene Expression 5

Gene Ontology 18

Phenotypes 19
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:343113 Santillo A, et al., D-Aspartate Depletion Perturbs Steroidogenesis and Spermatogenesis in Mice. Biomolecules. 2023 Mar 30;13(4)

TSS for Ddo:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr93026	Chr10:40505983-40506049 (+)	9 bp
Tssr93027	Chr10:40506053-40506059 (+)	49 bp
Tssr3184	Chr10:40521316-40521318 (+)	15,310 bp
Tssr93028	Chr10:40549065-40549106 (+)	43,079 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23