Nuak1 MGI Mouse Gene Detail - MGI:1925226 - NUAK family, SNF1-like kinase, 1

Symbol

Nuak1
Name

NUAK family, SNF1-like kinase, 1
Synonyms

B230104P22Rik

Feature Type

protein coding gene
IDs

MGI:1925226
NCBI Gene: 77976
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr10:84206769-84276461 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 41.42 cM
Mapping Data

2 experiments

SNPs within 2kb

239 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1925226	protein coding gene	Chr10:84206764-84282028 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017590	protein coding gene	Chr10:85229574-85303676 (-)
A/J	MGP_AJ_G0017570	protein coding gene	Chr10:82341147-82412148 (-)
AKR/J	MGP_AKRJ_G0017529	protein coding gene	Chr10:84625481-84696507 (-)
BALB/cJ	MGP_BALBcJ_G0017533	protein coding gene	Chr10:82588457-82660428 (-)
C3H/HeJ	MGP_C3HHeJ_G0017355	protein coding gene	Chr10:84712334-84782963 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017990	protein coding gene	Chr10:88127165-88199158 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015674	protein coding gene	Chr10:78170429-78241082 (-)
CAST/EiJ	MGP_CASTEiJ_G0016922	protein coding gene	Chr10:84570862-84637356 (-)
CBA/J	MGP_CBAJ_G0017325	protein coding gene	Chr10:91820099-91897067 (-)
DBA/2J	MGP_DBA2J_G0017431	protein coding gene	Chr10:81484611-81555302 (-)
FVB/NJ	MGP_FVBNJ_G0017425	protein coding gene	Chr10:80720758-80790141 (-)
LP/J	MGP_LPJ_G0017503	protein coding gene	Chr10:85872200-85947477 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017453	protein coding gene	Chr10:93425406-93498913 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018027	protein coding gene	Chr10:84543525-84625501 (-)
PWK/PhJ	MGP_PWKPhJ_G0016703	protein coding gene	Chr10:81342261-81411761 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016492	protein coding gene	Chr10:83166847-83241860 (-)
WSB/EiJ	MGP_WSBEiJ_G0016981	protein coding gene	Chr10:84541593-84615966 (-)

Human Ortholog

NUAK1, NUAK family kinase 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NUAK1, NUAK family kinase 1
Synonyms

ARK5
Links

HGNC:14311

NCBI Gene ID: 9891

neXtProt AC: NX_O60285

UniProt: O60285
Chr Location

12q23.3; chr12:106063345-106138954 (-) GRCh38

Alliance of Genome Resources

Nuak1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: NUAK1
Gene Tree

Nuak1

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Phenotype Summary

10 phenotypes from 2 alleles in 2 genetic backgrounds
10 phenotypes from multigenic genotypes
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Gene trapped

3
Targeted

5
Genomic Mutations

1 involving Nuak1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

33 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a targeted disruption of this gene die perinatally displaying omphalocele with a failure in closure of the secondary body wall. No gross morphological defects are detected in brain.

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All GO Annotations

26
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development	DNA-templated transcription

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

953
Tissues

98
cDNA Data

38
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN nuak1a, nuak1b

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Nuak1 interacts with 341 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

44
RefSeq

6
UniProt

2
CCDS

CCDS24079.1

Ensembl

ENSMUSG00000020032 (Evidence)
NCBI Gene

77976

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020032	Ensembl Gene Model \| MGI Sequence Detail	69693	C57BL/6J	± kb
transcript	ENSMUST00000020220	Ensembl \| MGI Sequence Detail	5558	Not Applicable
polypeptide	ENSMUSP00000020220	Ensembl \| MGI Sequence Detail	658	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000011473 NUAK family SNF1-like kinase 1

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

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All nucleic 40

cDNA 38

Primer pair 2

Microarray probesets 1

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MGI:2143718, MGI:2143843

Summaries

All 49

Developmental Gene Expression 10

Gene Ontology 4

Phenotypes 17
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:333462 Zhang T, et al., NUAK1 promotes organ fibrosis via YAP and TGF-beta/SMAD signaling. Sci Transl Med. 2022 Mar 23;14(637):eaaz4028

TSS for Nuak1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr98722	Chr10:84277164-84277224 (-)	-733 bp
Tssr98721	Chr10:84276549-84276569 (-)	-98 bp
Tssr98720	Chr10:84276523-84276539 (-)	-70 bp
Tssr98719	Chr10:84276515-84276522 (-)	-58 bp
Tssr98718	Chr10:84276503-84276514 (-)	-48 bp
Tssr98717	Chr10:84276487-84276494 (-)	-30 bp
Tssr98716	Chr10:84276474-84276483 (-)	-18 bp
Tssr98715	Chr10:84276455-84276468 (-)	-1 bp
Tssr98714	Chr10:84276400-84276411 (-)	55 bp
Tssr98713	Chr10:84276369-84276381 (-)	86 bp
Tssr98712	Chr10:84234519-84234531 (-)	41,936 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/28/2023 MGI 6.22