Prune2 MGI Mouse Gene Detail - MGI:1925004

Symbol

Prune2
Name

prune homolog 2
Synonyms

6330414G02Rik, A230083H22Rik, A330102H22Rik, Olfaxin

Feature Type

protein coding gene
IDs

MGI:1925004
NCBI Gene: 353211
Alliance

genome feature page
Transcription Start Sites

15 TSS

Sequence Map

Chr19:16933482-17201296 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 12.34 cM, cytoband B
Mapping Data

2 experiments

SNPs within 2kb

9072 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1925004	protein coding gene	Chr19:16933033-17201322 (+)
129S1/SvImJ	ENSMUSG00200019948	protein coding gene	Chr19:13631458-13896909 (+)
A/J	ENSMUSG00195016595	protein coding gene	Chr19:13778285-14044500 (+)
AKR/J	ENSMUSG00220010489	protein coding gene	Chr19:13763559-14029805 (+)
BALB/cJ	ENSMUSG00180016226	protein coding gene	Chr19:14142978-14412213 (+)
C3H/HeJ	ENSMUSG00175003356	protein coding gene	Chr19:13487050-13752967 (+)
C57BL/6NJ	ENSMUSG00215019144	protein coding gene	Chr19:13539340-13807500 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022799	protein coding gene	Chr19:14333301-14596236 (+)
CAST/EiJ	ENSTCUG00005008276	protein coding gene	Chr19:13386400-13650592 (+)
CBA/J	ENSMUSG00210012524	protein coding gene	Chr19:13686883-13963783 (+)
DBA/2J	ENSMUSG00185013054	protein coding gene	Chr19:14096372-14373289 (+)
FVB/NJ	ENSMUSG00205003328	protein coding gene	Chr19:13552074-13818282 (+)
JF1/MsJ	ENSUMUG00000020498	protein coding gene	Chr19:14332463-14602495 (+)
LP/J	ENSMUSG00230019109	protein coding gene	Chr19:14999554-15266130 (+)
NOD/ShiLtJ	ENSMUSG00190020273	protein coding gene	Chr19:13493171-13759367 (+)
NZO/HlLtJ	ENSMUSG00225045642	protein coding gene	Chr19:18723323-18989539 (+)
PWK/PhJ	ENSLUMG00010008183	protein coding gene	Chr19:13657080-13929371 (+)
SPRET/EiJ	ENSMSPG00010018471	protein coding gene	Chr19:13641303-13906737 (+)
WSB/EiJ	ENSIUOG00005007015	protein coding gene	Chr19:13212876-13478963 (+)

Human Ortholog

PRUNE2, prune homolog 2 with BCH domain

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PRUNE2, prune homolog 2 with BCH domain
Synonyms

BMCC1, BNIPXL, C9orf65, KIAA0367
Links

HGNC:25209

NCBI Gene ID: 158471

UniProt: Q8WUY3
Chr Location

9q21.2; chr9:76611376-76906591 (-) GRCh38

MGI Vertebrate Homology

Prune2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PRUNE2
Gene Tree

Prune2

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

167
Endonuclease-mediated

3
Gene trapped

162
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

176 strains or lines available

Mice homozygous for a null allele exhibit impaired odor preference and olfactory memory.

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All GO Annotations

10
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

964
Tissues

154
cDNA Data

17
Literature Summary

9

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase prune2

ZFIN prune2

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All Sequences

92
RefSeq

37
UniProt

5
CCDS

CCDS50400.1

Ensembl

ENSMUSG00000039126 (Evidence)
NCBI Gene

353211

			Length	Strain/Species	Flank
genomic	ENSMUSG00000039126	Ensembl Gene Model \| MGI Sequence Detail	267815	C57BL/6J	± kb
transcript	ENSMUST00000087689	Ensembl \| MGI Sequence Detail	12512	Not Applicable
polypeptide	ENSMUSP00000084977	Ensembl \| MGI Sequence Detail	3084	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000013335 protein prune homolog 2

(term hierarchy)
InterPro Domains

IPR022181 Bcl2-/adenovirus E1B 19kDa-interacting protein 2

IPR001251 CRAL-TRIO lipid binding domain

IPR036865 CRAL-TRIO lipid binding domain superfamily

IPR004097 DHHA2 domain

IPR038222 DHHA2 domain superfamily

IPR038763 DHH phosphoesterase superfamily
GlyGen

Q52KR3 1 site

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All nucleic 20

cDNA 17

Primer pair 1

Other 2

Microarray probesets 5

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MGI:1917972, MGI:2443750

Summaries

All 43

Developmental Gene Expression 9

Gene Ontology 5

Phenotypes 9
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:385686 Steklikova K, et al., Factors Involved in Enamel Knot Establishment and Cap Formation. J Dent Res. 2025 Jul;104(7):784-794

TSS for Prune2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr155414	Chr19:16933051-16933065 (+)	-424 bp
Tssr155415	Chr19:16933324-16933344 (+)	-148 bp
Tssr155416	Chr19:16933428-16933439 (+)	-48 bp
Tssr155417	Chr19:16933474-16933488 (+)	-1 bp
Tssr155418	Chr19:16933528-16933535 (+)	50 bp
Tssr155419	Chr19:17102982-17103034 (+)	169,526 bp
Tssr155420	Chr19:17114108-17114145 (+)	180,645 bp
Tssr155421	Chr19:17114172-17114183 (+)	180,696 bp
Tssr155422	Chr19:17114197-17114202 (+)	180,718 bp
Tssr5453	Chr19:17122919-17122923 (+)	189,439 bp
Tssr155423	Chr19:17182895-17182906 (+)	249,419 bp
Tssr155424	Chr19:17199840-17199852 (+)	266,364 bp
Tssr155425	Chr19:17199937-17199953 (+)	266,463 bp
Tssr155426	Chr19:17200015-17200018 (+)	266,535 bp
Tssr155427	Chr19:17200095-17200096 (+)	266,614 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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