Trat1 MGI Mouse Gene Detail - MGI:1924897 - T cell receptor associated transmembrane adaptor 1

Symbol

Trat1
Name

T cell receptor associated transmembrane adaptor 1
Synonyms

C030046M14Rik, Tcrim, Trim

Feature Type

protein coding gene
IDs

MGI:1924897
NCBI Gene: 77647
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr16:48551137-48592384 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 30.75 cM
Mapping Data

1 experiment

SNPs within 2kb

477 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1924897	protein coding gene	Chr16:48551137-48630883 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022866	protein coding gene	Chr16:47610033-47645285 (-)
A/J	MGP_AJ_G0022831	protein coding gene	Chr16:45513694-45550526 (-)
AKR/J	MGP_AKRJ_G0022804	protein coding gene	Chr16:47026055-47066830 (-)
BALB/cJ	MGP_BALBcJ_G0022833	protein coding gene	Chr16:45558265-45596499 (-)
C3H/HeJ	MGP_C3HHeJ_G0022596	protein coding gene	Chr16:47117971-47157582 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0023280	protein coding gene	Chr16:48785038-48830293 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020793	protein coding gene	Chr16:45643509-45678968 (-)
CAST/EiJ	MGP_CASTEiJ_G0022122	protein coding gene	Chr16:47368266-47407291 (-)
CBA/J	MGP_CBAJ_G0022569	protein coding gene	Chr16:50715426-50749805 (-)
DBA/2J	MGP_DBA2J_G0022700	protein coding gene	Chr16:45223829-45266277 (-)
FVB/NJ	MGP_FVBNJ_G0022676	protein coding gene	Chr16:45121262-45158436 (-)
LP/J	MGP_LPJ_G0022768	protein coding gene	Chr16:47355791-47397487 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022694	protein coding gene	Chr16:50389429-50430703 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023295	protein coding gene	Chr16:47014784-47066321 (-)
PWK/PhJ	MGP_PWKPhJ_G0021862	protein coding gene	Chr16:45581891-45618194 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021692	protein coding gene	Chr16:46905829-46948460 (-)
WSB/EiJ	MGP_WSBEiJ_G0022167	protein coding gene	Chr16:47068411-47111074 (-)

Human Ortholog

TRAT1, T cell receptor associated transmembrane adaptor 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TRAT1, T cell receptor associated transmembrane adaptor 1
Synonyms

HSPC062, pp29/30, TCRIM, TRIM
Links

HGNC:30698

NCBI Gene ID: 50852

neXtProt AC: NX_Q6PIZ9

UniProt: Q6PIZ9
Chr Location

3q13.13; chr3:108822770-108855005 (+) GRCh38

MGI Vertebrate Homology

Trat1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: TRAT1
Gene Tree

Trat1

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

3
Targeted

4
Incidental Mutations

Mutagenetix
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice with homozygous disruption of this gene display decreased body weight and a proportional reduction in lymph organ cell numbers; however T and B cell function are normal.

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All GO Annotations

12
GO References

4

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

16

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

45
RefSeq

6
UniProt

3
CCDS

CCDS37352.1

Ensembl

ENSMUSG00000030775 (Evidence)
NCBI Gene

77647

			Length	Strain/Species	Flank
genomic	ENSMUSG00000030775	Ensembl Gene Model \| MGI Sequence Detail	41248	C57BL/6J	± kb
transcript	ENSMUST00000239408	Ensembl \| MGI Sequence Detail	684	Not Applicable
polypeptide	ENSMUSP00000159369	Ensembl \| MGI Sequence Detail	197	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000016620 T-cell receptor-associated transmembrane adapter 1

(term hierarchy)
InterPro Domains

IPR020399 T-cell receptor-associated transmembrane adapter 1

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All nucleic 16

cDNA 16

Microarray probesets 3

Summaries

All 28

Gene Ontology 4

Phenotypes 6
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

TSS for Trat1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr141311	Chr16:48592508-48592520 (-)	-130 bp
Tssr141310	Chr16:48592465-48592506 (-)	-102 bp
Tssr141309	Chr16:48592415-48592432 (-)	-40 bp
Tssr141308	Chr16:48592399-48592414 (-)	-23 bp
Tssr141307	Chr16:48592372-48592393 (-)	1 bp
Tssr4889	Chr16:48592330-48592339 (-)	49 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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