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Limch1 Gene Detail
Summary
  • Symbol
    Limch1
  • Name
    LIM and calponin homology domains 1
  • Synonyms
    3732412D22Rik, mKIAA1102
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924819
    NCBI Gene: 77569
  • Alliance
    genome feature page
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:66903232-67214502 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 35.95 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    9265 from dbSNP Build 142
  • Strain Annotations
    20
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924819
 protein coding gene Chr5:66903170-67214502 (+)
129S1/SvImJ ENSMUSG00200035588
 protein coding gene Chr5:62530824-62848695 (+)
A/J ENSMUSG00195030068
 protein coding gene Chr5:61891850-62202714 (+)
AKR/J ENSMUSG00220003216
 protein coding gene Chr5:62029845-62340701 (+)
BALB/cJ ENSMUSG00180020573
 protein coding gene Chr5:61684685-61995543 (+)
C3H/HeJ ENSMUSG00175025574
 protein coding gene Chr5:63933405-64023063 (+)
C3H/HeJ ENSMUSGG00175054895
 protein coding gene Chr5:63712681-63909702 (+)
C57BL/6NJ ENSMUSG00215004756
 protein coding gene Chr5:62665847-62761952 (+)
C57BL/6NJ ENSMUSGG00215055541
 protein coding gene Chr5:62450547-62642158 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027262
 protein coding gene Chr5:60065999-60377168 (+)
CAST/EiJ ENSTCUG00005027254
 protein coding gene Chr5:61610066-61917587 (+)
CBA/J ENSMUSG00210023310
 protein coding gene Chr5:62625103-62935935 (+)
DBA/2J ENSMUSG00185005551
 protein coding gene Chr5:64482636-64793464 (+)
FVB/NJ ENSMUSGG00205054535
 protein coding gene Chr5:61437761-61629207 (+)
FVB/NJ ENSMUSG00205009750
 protein coding gene Chr5:61652892-61748974 (+)
JF1/MsJ no annotation
LP/J ENSMUSG00230007469
 protein coding gene Chr5:69143440-69461271 (+)
NOD/ShiLtJ ENSMUSG00190003838
 protein coding gene Chr5:61616677-61927469 (+)
NZO/HlLtJ ENSMUSG00225010069
 protein coding gene Chr5:74262066-74567180 (+)
PWK/PhJ ENSLUMG00010013348
 protein coding gene Chr5:61602756-61916071 (+)
SPRET/EiJ ENSMSPG00010032998
 protein coding gene Chr5:63394485-63704475 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    LIMCH1, LIM and calponin homology domains 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LIMCH1, LIM and calponin homology domains 1
  • Synonyms
    LIMCH1A, LMO7B
  • Links
    NCBI Gene ID: 22998
    UniProt: Q9UPQ0

  • Chr Location
    4p13; chr4:41359574-41700049 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a deletion of the six exons encoding the muscle-specific isoform, exclusively express the fetal predominant isoform in adult skeletal muscle and show decreased grip strength, muscle weakness, deficits in skeletal muscle force generation, and defects in calcium-handling during myofiber stimulation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    687
  • Tissues
    57
  • cDNA Data
    79
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 77569 NCBI Gene Model | MGI Sequence Detail 311271 C57BL/6J ±  kb
    transcript NM_001401420 RefSeq | MGI Sequence Detail 7606 C57BL/6  
    polypeptide Q3UH68 UniProt | EBI | MGI Sequence Detail 1057 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 82
      cDNA 79
      Primer pair 2
      Other 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 9
      Gene Ontology 6
      Phenotypes 26
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory