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Gprin3 Gene Detail
Summary
  • Symbol
    Gprin3
  • Name
    GPRIN family member 3
  • Synonyms
    C030038J10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924785
    NCBI Gene: 243385
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:59324211-59403279 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 28.48 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2145 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924785
 protein coding gene Chr6:59317988-59403291 (-)
129S1/SvImJ ENSMUSG00200005300
 protein coding gene Chr6:56284090-56363175 (-)
A/J ENSMUSG00195030940
 protein coding gene Chr6:55983316-56062401 (-)
AKR/J ENSMUSG00220005089
 protein coding gene Chr6:55452243-55531328 (-)
BALB/cJ ENSMUSG00180009526
 protein coding gene Chr6:56339721-56418803 (-)
C3H/HeJ ENSMUSG00175037788
 protein coding gene Chr6:56025601-56104679 (-)
C57BL/6NJ ENSMUSG00215017861
 protein coding gene Chr6:56319520-56398606 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028451
 protein coding gene Chr6:53437975-53519869 (-)
CAST/EiJ ENSTCUG00005038574
 protein coding gene Chr6:55521571-55601096 (-)
CBA/J ENSMUSG00210031915
 protein coding gene Chr6:56138261-56217338 (-)
DBA/2J ENSMUSG00185018645
 protein coding gene Chr6:56720609-56799687 (-)
FVB/NJ ENSMUSG00205022402
 protein coding gene Chr6:56205602-56284691 (-)
JF1/MsJ ENSUMUG00000032162
 protein coding gene Chr6:56141084-56226977 (-)
LP/J ENSMUSG00230011431
 protein coding gene Chr6:57840786-57919879 (-)
NOD/ShiLtJ ENSMUSG00190008394
 protein coding gene Chr6:55982169-56061244 (-)
NZO/HlLtJ ENSMUSG00225012658
 protein coding gene Chr6:59830113-59909191 (-)
PWK/PhJ ENSLUMG00010018114
 protein coding gene Chr6:55731623-55821974 (-)
SPRET/EiJ ENSMSPG00010007522
 protein coding gene Chr6:56533268-56608123 (-)
WSB/EiJ ENSIUOG00005019520
 protein coding gene Chr6:56326442-56405523 (-)



Homology
more
  • Human Ortholog
    GPRIN3, GPRIN family member 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GPRIN3, GPRIN family member 3
  • Synonyms
    GRIN3
  • Links
    NCBI Gene ID: 285513
    UniProt: Q6ZVF9

  • Chr Location
    4q22.1; chr4:89236383-89307937 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 2 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit increased motivation for reward, decreased locomotor response to cocaine, increased dendritic arborization of medium spiny neurons and decreased striatal neuron excitability.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    9
  • GO References
    3
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    598
  • Tissues
    1
  • cDNA Data
    5
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000045441 Ensembl Gene Model | MGI Sequence Detail 79069 C57BL/6J ±  kb
transcript ENSMUST00000051065 Ensembl | MGI Sequence Detail 8339 Not Applicable  
polypeptide ENSMUSP00000051805 Ensembl | MGI Sequence Detail 763 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000008201 G protein-regulated inducer of neurite outgrowth 3
    (term hierarchy)
  • InterPro Domains
    IPR026646 G protein-regulated inducer of neurite outgrowth
    IPR032745 G protein-regulated inducer of neurite outgrowth, C-terminal
  • GlyGen
    Q8BWS5 4 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)
Molecular
Reagents
less
  • All nucleic 5
    cDNA 5

    Microarray probesets 2
References
more
  • Summaries
    All 29
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:279507 Karadurmus D, et al., GPRIN3 Controls Neuronal Excitability, Morphology, and Striatal-Dependent Behaviors in the Indirect Pathway of the Striatum. J Neurosci. 2019 Sep 18;39(38):7513-7528
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory