Kidins220 MGI Mouse Gene Detail - MGI:1924730 - kinase D-interacting substrate 220

Symbol

Kidins220
Name

kinase D-interacting substrate 220
Synonyms

3110039L19Rik, C330002I19Rik, mKIAA1250

Feature Type

protein coding gene
IDs

MGI:1924730
NCBI Gene: 77480
Alliance

genome feature page
Transcription Start Sites

8 TSS

Sequence Map

Chr12:25024924-25113151 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 8.54 cM
Mapping Data

3 experiments

SNPs within 2kb

2730 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1924730	protein coding gene	Chr12:25024909-25113151 (+)
129S1/SvImJ	ENSMUSG00200022836	protein coding gene	Chr12:16773391-16860790 (+)
A/J	ENSMUSG00195018518	protein coding gene	Chr12:19497511-19585730 (+)
AKR/J	ENSMUSG00220025143	protein coding gene	Chr12:17448864-17536911 (+)
BALB/cJ	ENSMUSG00180008956	protein coding gene	Chr12:18440149-18528366 (+)
C3H/HeJ	ENSMUSG00175020760	protein coding gene	Chr12:21497709-21585661 (+)
C57BL/6NJ	ENSMUSG00215005386	protein coding gene	Chr12:17920238-18008463 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017650	protein coding gene	Chr12:21525200-21613729 (+)
CAST/EiJ	ENSTCUG00005005199	protein coding gene	Chr12:18307821-18395633 (+)
CBA/J	ENSMUSG00210007357	protein coding gene	Chr12:17983901-18071854 (+)
DBA/2J	ENSMUSG00185003732	protein coding gene	Chr12:20013981-20102012 (+)
FVB/NJ	ENSMUSG00205001631	protein coding gene	Chr12:18084294-18171685 (+)
JF1/MsJ	ENSUMUG00000005062	protein coding gene	Chr12:24227080-24315321 (+)
LP/J	ENSMUSG00230006285	protein coding gene	Chr12:26982824-27071450 (+)
NOD/ShiLtJ	ENSMUSG00190012835	protein coding gene	Chr12:16947130-17035341 (+)
NZO/HlLtJ	ENSMUSG00225033738	protein coding gene	Chr12:29165913-29254543 (+)
PWK/PhJ	ENSLUMG00010004024	protein coding gene	Chr12:18501268-18589193 (+)
SPRET/EiJ	ENSMSPG00010002421	protein coding gene	Chr12:18770805-18857715 (+)
WSB/EiJ	ENSIUOG00005001599	protein coding gene	Chr12:17643713-17731760 (+)

Human Ortholog

KIDINS220, kinase D interacting substrate 220

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KIDINS220, kinase D interacting substrate 220
Synonyms

ARMS, SINO, VENARG
Links

HGNC:29508

NCBI Gene ID: 57498

UniProt: Q9ULH0
Chr Location

2p25.1; chr2:8721081-8837630 (-) GRCh38

MGI Vertebrate Homology

Kidins220 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: KIDINS220
Gene Tree

Kidins220

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Phenotype Summary

19 phenotypes from 2 alleles in 3 genetic backgrounds
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

2
Gene trapped

2
Targeted

6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

79 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit embryonic lethality. Mice heterozygous for a knock-out allele exhibit decreased dendritic complexity in the barrel somatosensory cortex and dentate gyrus neurons.

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All GO Annotations

18
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

859
Tissues

42
cDNA Data

13
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA KIDINS220

Xenbase kidins220

ZFIN kidins220b

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All Sequences

116
RefSeq

35
UniProt

17
CCDS

CCDS36424.1

Ensembl

ENSMUSG00000036333 (Evidence)
NCBI Gene

77480

			Length	Strain/Species	Flank
genomic	ENSMUSG00000036333	Ensembl Gene Model \| MGI Sequence Detail	88228	C57BL/6J	± kb
transcript	ENSMUST00000066652	Ensembl \| MGI Sequence Detail	7409	Not Applicable
polypeptide	ENSMUSP00000063999	Ensembl \| MGI Sequence Detail	1793	Not Applicable

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UniProt

17 Sequences
InterPro Domains

IPR002110 Ankyrin repeat

IPR036770 Ankyrin repeat-containing domain superfamily

IPR011646 KAP family P-loop domain

IPR052771 Kinase D-interacting substrate of 220 kDa

IPR057092 Kinase D-interacting substrate of 220 kDa-like, SAM domain

IPR013761 Sterile alpha motif/pointed domain superfamily
GlyGen

E9Q9B7 4 sites, 3 N-linked glycans (3 sites)

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All nucleic 19

cDNA 13

Primer pair 4

Other 2

Antibodies 7

Microarray probesets 9

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MGI:1920401, MGI:2144771, MGI:2144787

Summaries

All 55

Developmental Gene Expression 6

Gene Ontology 5

Phenotypes 19
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:370562 Herr LA, et al., Kidins220 and Aiolos promote thymic iNKT cell development by reducing TCR signals. Sci Adv. 2024 Mar 15;10(11):eadj2802

TSS for Kidins220:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr112971	Chr12:25023805-25023812 (+)	-1,115 bp
Tssr112972	Chr12:25023890-25023901 (+)	-1,028 bp
Tssr112973	Chr12:25024913-25024947 (+)	6 bp
Tssr112974	Chr12:25032268-25032285 (+)	7,353 bp
Tssr112975	Chr12:25039756-25039768 (+)	14,838 bp
Tssr112976	Chr12:25088354-25088379 (+)	63,443 bp
Tssr112977	Chr12:25090094-25090101 (+)	65,174 bp
Tssr112978	Chr12:25092661-25092665 (+)	67,739 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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